{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:33:47Z","timestamp":1791920027196,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.bmc.2012.10.058","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T07:16:36Z","timestamp":1352963796000},"page":"102-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B\/NS3 proteases"],"prefix":"10.1016","volume":"21","author":[{"given":"Huiguo","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengfeng","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar","family":"Aravapalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadahisa","family":"Teramoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald H.","family":"Lushington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom M.","family":"Mwania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Alliston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Eichhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakrishnan","family":"Padmanabhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Groutas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2012.10.058_b0260","first-page":"1101","volume":"Vol. 1","author":"Lindenbach","year":"2007"},{"key":"10.1016\/j.bmc.2012.10.058_b0010","doi-asserted-by":"crossref","first-page":"14333","DOI":"10.1073\/pnas.2335168100","volume":"100","author":"Mu\u00f1oz-Jord\u03acn","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2012.10.058_b0015","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1001\/jama.2007.31-a","volume":"299","author":"Morens","year":"2008","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bmc.2012.10.058_b0020","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1365-3156.2007.01891.x","volume":"12","author":"Gulati","year":"2007","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.bmc.2012.10.058_b0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.antiviral.2008.08.004","volume":"81","author":"Sampath","year":"2009","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bmc.2012.10.058_b0030","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.antiviral.2008.07.001","volume":"80","author":"Lescar","year":"2008","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bmc.2012.10.058_b0035","doi-asserted-by":"crossref","first-page":"9963","DOI":"10.1074\/jbc.275.14.9963","volume":"275","author":"Yusof","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0040","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1590\/S1415-47572010000200002","volume":"33","author":"Natarajan","year":"2010","journal-title":"Genet. Mol. Biol."},{"key":"10.1016\/j.bmc.2012.10.058_b0045","doi-asserted-by":"crossref","first-page":"6686","DOI":"10.1128\/JVI.02215-05","volume":"80","author":"Sampath","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.bmc.2012.10.058_b0050","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nrd1853","volume":"4","author":"Kwong","year":"2005","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2012.10.058_b0055","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1074\/jbc.M110.179184","volume":"286","author":"Lim","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0060","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1021\/jm900776m","volume":"53","author":"Podvinec","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0065","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.antiviral.2009.03.005","volume":"83","author":"Puig-Basagoiti","year":"2009","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bmc.2012.10.058_b0070","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1128\/AAC.01508-07","volume":"52","author":"Mueller","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2012.10.058_b0075","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.biocel.2006.10.025","volume":"39","author":"Mueller","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bmc.2012.10.058_b0080","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/cc100091h","volume":"12","author":"Dou","year":"2010","journal-title":"J. Comb. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0085","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.bmc.2011.12.047","volume":"20","author":"Tiew","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0090","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1016\/j.bmc.2012.04.055","volume":"20","author":"Aravapalli","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0095","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1128\/AAC.00140-10","volume":"54","author":"Chen","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2012.10.058_b0100","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.antiviral.2006.01.008","volume":"70","author":"Torrence","year":"2006","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bmc.2012.10.058_b0105","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1128\/AAC.00855-10","volume":"55","author":"Yang","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2012.10.058_b0110","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.antiviral.2009.02.190","volume":"82","author":"Tomlinson","year":"2009","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bmc.2012.10.058_b0115","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1128\/JVI.06225-11","volume":"86","author":"Noble","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.bmc.2012.10.058_b0120","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3851\/IMP1690","volume":"21","author":"Julander","year":"2011","journal-title":"Antiviral Chem. Chemother."},{"key":"10.1016\/j.bmc.2012.10.058_b0125","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.2174\/092986708786242804","volume":"15","author":"Chappell","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0130","first-page":"493","volume":"51","author":"Mor","year":"1996","journal-title":"Il Pharmaco"},{"key":"10.1016\/j.bmc.2012.10.058_b0135","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1016\/j.bmcl.2011.05.127","volume":"21","author":"Jorgensen","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.10.058_b0140","doi-asserted-by":"crossref","first-page":"7321","DOI":"10.1016\/j.bmcl.2011.10.026","volume":"21","author":"Matuszak","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.10.058_b0145","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/BF02977894","volume":"28","author":"Morini","year":"2005","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.bmc.2012.10.058_b0150","doi-asserted-by":"crossref","first-page":"328","DOI":"10.6026\/97320630007328","volume":"7","author":"Mahmoud","year":"2011","journal-title":"Bioinformation"},{"key":"10.1016\/j.bmc.2012.10.058_b0155","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/13651500500487586","volume":"10","author":"Matsunaga","year":"2006","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"10.1016\/j.bmc.2012.10.058_b0160","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1016\/S0960-894X(01)80782-4","volume":"3","author":"Wright","year":"1993","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.10.058_b0165","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1016\/j.bmc.2011.08.029","volume":"19","author":"Dou","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0170","first-page":"55","volume":"2012","author":"Bostrom","year":"1817","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0175","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.bmc.2011.12.031","volume":"20","author":"Zoumpoulakis","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0180","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1039\/C1OB06512B","volume":"10","author":"Pouliot","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0185","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1016\/j.tetlet.2010.06.139","volume":"51","author":"Stabile","year":"2010","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2012.10.058_b0190","doi-asserted-by":"crossref","first-page":"27412","DOI":"10.1074\/jbc.M501393200","volume":"280","author":"Yon","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0195","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.antiviral.2012.02.003","volume":"94","author":"Ezgimen","year":"2012","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bmc.2012.10.058_b0200","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nsmb1073","volume":"13","author":"Erbel","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bmc.2012.10.058_b0205","doi-asserted-by":"crossref","first-page":"19205","DOI":"10.1021\/ja208435s","volume":"133","author":"De la Cruz","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2012.10.058_b0210","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.jmb.2008.11.026","volume":"385","author":"Robin","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2012.10.058_b0215","first-page":"293","volume":"39","author":"Gillespie","year":"2004","journal-title":"Annu. Rep. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0220","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1021\/jm100118x","volume":"53","author":"Perola","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.10.058_b0225","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/tx200211v","volume":"24","author":"Meanwell","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bmc.2012.10.058_b0230","unstructured":"APEX2 User Manual, Bruker AXS, Madison (USA), 2005."},{"key":"10.1016\/j.bmc.2012.10.058_b0235","unstructured":"SAINT software reference manual, Version 4, Bruker AXS, Madison (USA), 1994\u20131996."},{"key":"10.1016\/j.bmc.2012.10.058_b0240","unstructured":"Sheldrick, G., SADABS (Version 2.03), University of G\u00f6ttingen, Germany, 2002."},{"key":"10.1016\/j.bmc.2012.10.058_b0245","unstructured":"SHELXTL reference manual, Version 5.1, Bruker AXS, Madison (USA), 1997."},{"key":"10.1016\/j.bmc.2012.10.058_b0250","series-title":"Enzyme Kinetics","author":"Segel","year":"1993"},{"key":"10.1016\/j.bmc.2012.10.058_b0255","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089612008887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089612008887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:07:16Z","timestamp":1760832436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089612008887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0968089612008887"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2012.10.058","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B\/NS3 proteases","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2012.10.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}