{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:57:25Z","timestamp":1778126245634,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.bmc.2012.11.014","type":"journal-article","created":{"date-parts":[[2012,11,24]],"date-time":"2012-11-24T15:37:53Z","timestamp":1353771473000},"page":"514-522","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Synthesis and preliminary evaluation of pharmacological properties of some piperazine derivatives of xanthone"],"prefix":"10.1016","volume":"21","author":[{"given":"Natalia","family":"Szkaradek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rapacz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Pytka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Filipek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Siwek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Ceg\u0142a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henryk","family":"Marona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2012.11.014_b0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/bmb\/ldp028","volume":"92","author":"Mathers","year":"2009","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.bmc.2012.11.014_b0010","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/01.RES.0000091829.63501.A8","volume":"93","author":"Sanguinetti","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.bmc.2012.11.014_b0015","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1080\/080370500300000905","volume":"9","author":"Bardage","year":"2000","journal-title":"Blood Press."},{"key":"10.1016\/j.bmc.2012.11.014_b0020","first-page":"122","volume":"40","author":"Valenti","year":"1990","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.bmc.2012.11.014_b0025","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/01.HYP.18.5.598","volume":"18","author":"Ford","year":"1991","journal-title":"Hypertension"},{"key":"10.1016\/j.bmc.2012.11.014_b0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-2999(97)01224-7","volume":"336","author":"Cheng","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2012.11.014_b0035","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0968-0896(01)00315-7","volume":"10","author":"Wang","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2012.11.014_b0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ardp.200800002","volume":"342","author":"Lin","year":"2009","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.bmc.2012.11.014_b0045","first-page":"267","volume":"143","author":"Librowski","year":"2004","journal-title":"Boll. Chim. Farm."},{"key":"10.1016\/j.bmc.2012.11.014_b0050","first-page":"383","volume":"65","author":"Marona","year":"2008","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/j.bmc.2012.11.014_b0055","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0223-5234(01)01321-6","volume":"37","author":"Malawska","year":"2002","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.11.014_b0060","first-page":"219","volume":"53","author":"Marona","year":"1998","journal-title":"Pharmazie"},{"key":"10.1016\/j.bmc.2012.11.014_b0065","first-page":"63","volume":"54","author":"Marona","year":"1997","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/j.bmc.2012.11.014_b0070","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/ardp.200700156","volume":"341","author":"Marona","year":"2008","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.bmc.2012.11.014_b0075","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.bmc.2008.12.031","volume":"17","author":"Marona","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2012.11.014_b0080","first-page":"672","volume":"53","author":"Marona","year":"1998","journal-title":"Pharmazie"},{"key":"10.1016\/j.bmc.2012.11.014_b0085","first-page":"131","article-title":"Handbook of Experimental Pharmacology","author":"Schmier","year":"1975"},{"key":"10.1016\/j.bmc.2012.11.014_b0090","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","volume":"96","author":"Litchfield","year":"1949","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2012.11.014_b0095","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0014-2999(85)90328-0","volume":"119","author":"Maj","year":"1985","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2012.11.014_b0100","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","volume":"22","author":"Cheng","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bmc.2012.11.014_b0105","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.yjmcc.2010.11.014","volume":"51","author":"Jensen","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bmc.2012.11.014_b0110","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1254\/jphs.CRJ06001X","volume":"100","author":"Brodde","year":"2006","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bmc.2012.11.014_b0115","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1440-1681.2007.04707.x","volume":"34","author":"Woodcock","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bmc.2012.11.014_b0120","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1002\/cber.190503802155","volume":"38","author":"Ullmann","year":"1905","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"10.1016\/j.bmc.2012.11.014_b0125","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1002\/cber.190503802154","volume":"38","author":"Ullmann","year":"1905","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"10.1016\/j.bmc.2012.11.014_b0130","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1021\/jm00273a013","volume":"15","author":"Crowther","year":"1972","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.11.014_b0135","unstructured":"Howe, R. McLoughlin British Patent 1,058,822, 1967."},{"key":"10.1016\/j.bmc.2012.11.014_b0140","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ejmech.2008.05.019","volume":"44","author":"Groszek","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.11.014_b0145","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1734-1140(10)70244-9","volume":"62","author":"Kulig","year":"2010","journal-title":"Pharmacol. Rep."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961200898X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961200898X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:05:47Z","timestamp":1760832347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808961200898X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S096808961200898X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2012.11.014","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and preliminary evaluation of pharmacological properties of some piperazine derivatives of xanthone","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2012.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}