{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:46:59Z","timestamp":1789152419307,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.bmc.2012.12.001","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T08:52:34Z","timestamp":1355993554000},"page":"1344-1348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies"],"prefix":"10.1016","volume":"21","author":[{"given":"Peter","family":"\u0160ilh\u00e1r","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R.","family":"Silvaggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Pellett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate\u0159ina","family":"\u010capkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen N.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim D.","family":"Janda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2012.12.001_b0005","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrd1694","volume":"4","author":"Burnett","year":"2005","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2012.12.001_b0010","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/mr.56.1.80-99.1992","volume":"56","author":"Schantz","year":"1992","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.bmc.2012.12.001_b0015","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.pharmtox.44.101802.121554","volume":"44","author":"Simpson","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bmc.2012.12.001_b0020","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1086\/508176","volume":"43","author":"Kongsaengdao","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bmc.2012.12.001_b0030","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2174\/157340607781024438","volume":"3","author":"Hackett","year":"2007","journal-title":"Med. Chem."},{"key":"10.1016\/j.bmc.2012.12.001_b0035","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.parkreldis.2006.06.002","volume":"12","author":"Truong","year":"2006","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.bmc.2012.12.001_b0040","doi-asserted-by":"crossref","first-page":"8360","DOI":"10.1002\/anie.200705531","volume":"47","author":"Willis","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bmc.2012.12.001_b0045","doi-asserted-by":"crossref","first-page":"442","DOI":"10.7326\/0003-4819-95-4-442","volume":"95","author":"Hughes","year":"1981","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bmc.2012.12.001_b0050","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3390\/molecules16010202","volume":"16","author":"Li","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2012.12.001_b0055","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1021\/ol902820z","volume":"12","author":"Stowe","year":"2010","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmc.2012.12.001_b0060","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1039\/b808305c","author":"\u010capkova","year":"2008","journal-title":"Chem. Commun. (Camb)"},{"key":"10.1016\/j.bmc.2012.12.001_b0065","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1021\/ol0603211","volume":"8","author":"Boldt","year":"2006","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmc.2012.12.001_b0070","doi-asserted-by":"crossref","first-page":"e7730","DOI":"10.1371\/journal.pone.0007730","volume":"4","author":"Pang","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2012.12.001_b0075","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.chembiol.2007.03.014","volume":"14","author":"Silvaggi","year":"2007","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmc.2012.12.001_b0085","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1021\/bi8001067","volume":"47","author":"Silvaggi","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2012.12.001_b0090","doi-asserted-by":"crossref","first-page":"18883","DOI":"10.1074\/jbc.M801240200","volume":"283","author":"Kumaran","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2012.12.001_b0100","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/cber.19620950314","volume":"95","author":"Stetter","year":"1962","journal-title":"Chem. Ber."},{"key":"10.1016\/j.bmc.2012.12.001_b0105","first-page":"467","volume":"62","author":"Yurchenko","year":"1992","journal-title":"J. Gen. Chem. USSR (Engl. Transl.)"},{"key":"10.1016\/j.bmc.2012.12.001_b0110","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1016\/j.bmcl.2009.07.127","volume":"19","author":"Min","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.12.001_b0115","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1021\/jm00241a015","volume":"18","author":"Aigami","year":"1975","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2012.12.001_b0125","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1002\/cber.19590920722","volume":"92","author":"Stetter","year":"1959","journal-title":"Chem. Ber."},{"key":"10.1016\/j.bmc.2012.12.001_b0130","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/ange.19600721710","volume":"72","author":"Koch","year":"1960","journal-title":"Angew. Chem."},{"key":"10.1016\/j.bmc.2012.12.001_b0135","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.bmcl.2006.11.053","volume":"17","author":"Lienard","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2012.12.001_b0140","unstructured":"Anderson, G. L.; Kaimari, T. A.-R., U.S. Patent 6864264 B1, 2005."},{"key":"10.1016\/j.bmc.2012.12.001_b0145","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1080\/00397910903026723","volume":"40","author":"Usachova","year":"2010","journal-title":"Synth. Commun."},{"key":"10.1016\/j.bmc.2012.12.001_b0150","doi-asserted-by":"crossref","unstructured":"Shine, N. R. U.S. Patent 6504,006 B1, 2003.","DOI":"10.1088\/1126-6708\/2003\/04\/006"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089612009479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089612009479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:10:22Z","timestamp":1760832622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089612009479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0968089612009479"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2012.12.001","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2012.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}