{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:11:47Z","timestamp":1777493507794,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.bmc.2012.12.033","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T15:06:25Z","timestamp":1357225585000},"page":"841-846","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from \u03b1-hydroxyamides"],"prefix":"10.1016","volume":"21","author":[{"given":"Valentina","family":"Pastore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laureano","family":"Sabatier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Enrique","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariel","family":"Marder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis E.","family":"Bruno-Blanch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2012.12.033_b0005","first-page":"306","volume":"11","author":"Bell","year":"2002","journal-title":"Seizure"},{"key":"10.1016\/j.bmc.2012.12.033_b0010","doi-asserted-by":"crossref","first-page":"873","DOI":"10.2174\/1381612003400308","volume":"6","author":"Lopes Lima","year":"2000","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2012.12.033_b0015","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00007691-200202000-00013","volume":"24","author":"Perucca","year":"2002","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.bmc.2012.12.033_b0020","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2165\/00003495-200161100-00004","volume":"61","author":"Berk","year":"2001","journal-title":"Drugs"},{"key":"10.1016\/j.bmc.2012.12.033_b0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1528-1167.2007.00993.x","volume":"48","author":"L\u00f6scher","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.bmc.2012.12.033_b0030","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1528-1167.2007.01041.x","volume":"48","author":"Zaccara","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.bmc.2012.12.033_b0035","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.addr.2011.11.006","volume":"64","author":"Bialer","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1016\/j.bmc.2012.12.033_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2008.09.005","volume":"83","author":"Bialer","year":"2009","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.bmc.2012.12.033_b0045","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1528-1167.2009.02041.x","volume":"50","author":"Shorvon","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.bmc.2012.12.033_b0050","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1600-0404.2005.00513.x","volume":"112","author":"Klitgaard","year":"2005","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.bmc.2012.12.033_b0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1046\/j.1528-1157.44.s.1.1.x","volume":"44","author":"Sander","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.bmc.2012.12.033_b0060","first-page":"59","volume":"1912","author":"Hauptmann","year":"1907","journal-title":"M\u00fcnch. Med. Wochenschr"},{"key":"10.1016\/j.bmc.2012.12.033_b0065","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1176\/ajp.96.5.1023","volume":"96","author":"Merritt","year":"1940","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bmc.2012.12.033_b0070","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.3390\/ph3072090","volume":"3","author":"Wahab","year":"2010","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bmc.2012.12.033_b0075","doi-asserted-by":"crossref","first-page":"955","DOI":"10.2165\/00023210-200115120-00005","volume":"15","author":"Nicolson","year":"2001","journal-title":"CNS Drugs"},{"key":"10.1016\/j.bmc.2012.12.033_b0080","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2174\/156802612800229215","volume":"12","author":"Dalkara","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2012.12.033_b0085","first-page":"79","volume":"521","author":"Barton","year":"2005","journal-title":"Pharmacology"},{"key":"10.1016\/j.bmc.2012.12.033_b0090","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.seizure.2006.08.008","volume":"15","author":"Beran","year":"2006","journal-title":"Seizure"},{"key":"10.1016\/j.bmc.2012.12.033_b0095","series-title":"Antiepileptic Drugs","first-page":"85","author":"Swinyard","year":"1989"},{"key":"10.1016\/j.bmc.2012.12.033_b0100","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.1021\/ja01533a042","author":"Shapiro","year":"1959","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2012.12.033_b0105","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1021\/ja01532a052","author":"Shapiro","year":"1959","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2012.12.033_b0110","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1055\/s-1985-31460","author":"Khalaj","year":"1985","journal-title":"Synthesis"},{"key":"10.1016\/j.bmc.2012.12.033_b0115","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1021\/jo00048a011","volume":"57","author":"Solladie-Cavallo","year":"1992","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2012.12.033_b0120","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1016\/S0040-4039(00)79397-X","volume":"32","author":"Kiely","year":"1991","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2012.12.033_b0125","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/ange.19860980625","volume":"98","author":"Matsumt","year":"1986","journal-title":"Angew. Chem."},{"key":"10.1016\/j.bmc.2012.12.033_b0130","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1023\/A:1005616824806","author":"Valerio-Alfaro","year":"2000","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.bmc.2012.12.033_b0135","first-page":"3083","author":"Shapiro","year":"1959","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2012.12.033_b0140","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1016\/S0040-4020(03)00284-9","volume":"59","author":"Mel\u00e9ndez","year":"2003","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2012.12.033_b0145","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1021\/jo0157019","volume":"67","author":"Posakony","year":"2002","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2012.12.033_b0150","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1021\/jo00009a045","volume":"56","author":"White","year":"1991","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2012.12.033_b0155","series-title":"Molecular and Cellular Targets for Anti-epileptic Drugs","first-page":"191","author":"Stables","year":"1997"},{"key":"10.1016\/j.bmc.2012.12.033_b0160","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jps.3030460322","volume":"46","author":"Dunhan","year":"1957","journal-title":"J. Am. Pharmacol. Assoc. Sci. Ed."},{"key":"10.1016\/j.bmc.2012.12.033_b0165","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrn1430","volume":"5","author":"Rogawski","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bmc.2012.12.033_b0170","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1528-1157.1978.tb04507.x","volume":"19","author":"Krall","year":"1978","journal-title":"Epilepsia"},{"key":"10.1016\/j.bmc.2012.12.033_b0175","series-title":"Foye\u2019s Chapter 16 In Principles of Medicinal Chemistry","author":"Williams","year":"2002"},{"key":"10.1016\/j.bmc.2012.12.033_b0180","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bmc.2003.10.036","volume":"12","author":"Malawska","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2012.12.033_b0185","unstructured":"QSAR Properties Version 7.00. HyperChem Release 7.01 for Windows Molecular Modeling System 2002, Hypecube Inc., 1115 NW 4th Street, Gainesville, Florida 32601, USA."},{"key":"10.1016\/j.bmc.2012.12.033_b0190","first-page":"91","volume":"18","author":"Hadjipavlou-Litina","year":"1998","journal-title":"Med. Chem. Rev."},{"key":"10.1016\/j.bmc.2012.12.033_b0195","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0065-2725(08)60361-X","volume":"68","author":"Katrizky","year":"1997","journal-title":"Adv. Heterocycl. Chem."},{"key":"10.1016\/j.bmc.2012.12.033_b0200","doi-asserted-by":"crossref","first-page":"6386","DOI":"10.1016\/j.tet.2005.03.122","volume":"61","author":"Han","year":"2005","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2012.12.033_b0205","series-title":"Antiepileptic Drugs","first-page":"36","author":"White","year":"2002"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089612010061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089612010061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:06:51Z","timestamp":1760832411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089612010061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0968089612010061"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2012.12.033","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from \u03b1-hydroxyamides","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2012.12.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}