{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:36:03Z","timestamp":1791081363207,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.bmc.2013.03.030","type":"journal-article","created":{"date-parts":[[2013,3,29]],"date-time":"2013-03-29T23:11:06Z","timestamp":1364598666000},"page":"3154-3163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Selective CB2 agonists with anti-pruritic activity: Discovery of potent and orally available bicyclic 2-pyridones"],"prefix":"10.1016","volume":"21","author":[{"given":"Ken-ichi","family":"Kusakabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyoshi","family":"Iso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Tada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Sakagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Morioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Chomei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Shinonome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Takenaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Hamana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohji","family":"Hanasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.03.030_b0005","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1517\/14656566.2010.484420","volume":"11","author":"Patel","year":"2010","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.bmc.2013.03.030_b0010","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrn1950","volume":"7","author":"Ikoma","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bmc.2013.03.030_b0015","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s11882-008-0049-z","volume":"8","author":"Yosipovitch","year":"2008","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.bmc.2013.03.030_b0020","unstructured":"Stakeholder Opinions: Atopic dermatitis; DMHC2279; Datamonitor: New York, March 2007."},{"key":"10.1016\/j.bmc.2013.03.030_b0025","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00011-003-1162-z","volume":"52","author":"Dvorak","year":"2003","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bmc.2013.03.030_b0030","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ejphar.2006.05.040","volume":"542","author":"Maekawa","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2013.03.030_b0035","doi-asserted-by":"crossref","first-page":"14228","DOI":"10.1073\/pnas.96.25.14228","volume":"96","author":"Hanus","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.03.030_b0040","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0304-3959(01)00321-9","volume":"93","author":"Malan","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.bmc.2013.03.030_h0040","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1016\/S0968-0896(01)00155-9","volume":"9","author":"Huffman","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.030_h0045","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1021\/jm061195+","volume":"50","author":"Giblin","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.030_h0050","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1021\/jm9009857","volume":"52","author":"Giblin","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.030_h0055","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1021\/jm800463f","volume":"51","author":"Cheng","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.030_h0060","doi-asserted-by":"crossref","first-page":"7350","DOI":"10.1021\/jm200916p","volume":"54","author":"van der Stelt","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.030_h0065","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1021\/jm901214q","volume":"53","author":"Frost","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.030_h0070","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1021\/jm7011613","volume":"51","author":"Frost","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.030_h0075","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1021\/jm050467q","volume":"49","author":"Stern","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.030_h0080","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1021\/jm070387h","volume":"50","author":"Stern","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.030_b0050","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.bmc.2013.01.006","volume":"21","author":"Kusakabe","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.030_b0055","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0022-3565(25)38122-X","volume":"265","author":"Compton","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2013.03.030_b0060","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0022-3565(25)20744-3","volume":"278","author":"Showalter","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2013.03.030_b0065","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0306-3623(93)90154-P","volume":"24","author":"Pertwee","year":"1993","journal-title":"Gen. Pharmacol. Vasc. Syst."},{"key":"10.1016\/j.bmc.2013.03.030_b0070","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature10361","volume":"477","author":"Rasmussen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2013.03.030_h0110","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1021\/ci700352q","volume":"48","author":"Goto","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmc.2013.03.030_j0010","unstructured":"ASEDock Version RSI2010.07.14; Ryoka Systems: Tokyo, Japan."},{"key":"10.1016\/j.bmc.2013.03.030_b0080","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0014-2999(98)00974-1","volume":"367","author":"Inagaki","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2013.03.030_h0120","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1016\/j.bmcl.2007.04.093","volume":"17","author":"Kai","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.03.030_h0125","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1016\/j.bmcl.2007.04.099","volume":"17","author":"Kai","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.03.030_h0130","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.1016\/j.bmcl.2008.10.070","volume":"18","author":"Kai","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.03.030_b0090","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1016\/j.bmcl.2012.02.072","volume":"22","author":"Odan","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.03.030_b0095","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1016\/j.bmcl.2012.02.050","volume":"22","author":"Odan","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.03.030_b0100","first-page":"366","volume":"Vol. 25","author":"Ballesteros","year":"1995"},{"key":"10.1016\/j.bmc.2013.03.030_b0105","unstructured":"PyMOL, Version 0.98; DeLano Scientific: San Carlos, CA, USA."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613002447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613002447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:10:12Z","timestamp":1760832612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089613002447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0968089613002447"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.03.030","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective CB2 agonists with anti-pruritic activity: Discovery of potent and orally available bicyclic 2-pyridones","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.03.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}