{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:35:58Z","timestamp":1790058958745,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.bmc.2013.03.052","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T23:04:13Z","timestamp":1364857453000},"page":"3080-3089","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Synthesis and evaluation of 7-chloro-4-(piperazin-1-yl)quinoline-sulfonamide as hybrid antiprotozoal agents"],"prefix":"10.1016","volume":"21","author":[{"given":"Attar","family":"Salahuddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afreen","family":"Inam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn L.","family":"van Zyl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donovan C.","family":"Heslop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Teng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Avecilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash M.","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Azam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.03.052_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1874104501105010001","volume":"5","author":"Monzote","year":"2011","journal-title":"Open Med. Chem. J."},{"key":"10.1016\/j.bmc.2013.03.052_b0010","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1128\/CMR.00027-07","volume":"20","author":"Collins","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.bmc.2013.03.052_h0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2174\/157340707780809590","volume":"3","author":"Azam","year":"2007","journal-title":"Curr. Bioact. Compd."},{"key":"10.1016\/j.bmc.2013.03.052_h0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijpara.2007.09.009","volume":"38","author":"Agarwal","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bmc.2013.03.052_b0020","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ddr.20345","volume":"71","author":"Muregi","year":"2010","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.bmc.2013.03.052_b0025","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1371\/journal.pmed.0020105","volume":"2","author":"Garner","year":"2005","journal-title":"PLoS Med."},{"key":"10.1016\/j.bmc.2013.03.052_b0030","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.bmcl.2009.02.013","volume":"19","author":"Ara\u00fajo","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.03.052_h0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/1439-7633(20001117)1:4<281::AID-CBIC281>3.0.CO;2-W","volume":"1","author":"Dechy-Cabaret","year":"2000","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bmc.2013.03.052_h0045","first-page":"45","volume":"2001","author":"Basco","year":"1886","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.03.052_h0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1021\/ar990164o","volume":"35","author":"Robert","year":"2002","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bmc.2013.03.052_h0055","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ar7000843","volume":"41","author":"Meunier","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bmc.2013.03.052_b0040","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1021\/jm100117e","volume":"53","author":"Bellot","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.052_h0065","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1002\/cmdc.201200257","volume":"7","author":"P\u00e9rez","year":"2012","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2013.03.052_h0070","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1002\/cmdc.200800172","volume":"3","author":"October","year":"2008","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2013.03.052_h0075","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1021\/jm060399n","volume":"49","author":"Burgess","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.052_h0080","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1021\/jm200149e","volume":"54","author":"Eric","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.052_b0050","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1128\/AAC.39.8.1756","volume":"39","author":"Hong","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.03.052_b0055","doi-asserted-by":"crossref","first-page":"S433","DOI":"10.1093\/infdis\/128.Supplement_3.S433","volume":"128","author":"Hitchings","year":"1973","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bmc.2013.03.052_b0060","first-page":"281","volume":"60","author":"Boison","year":"1996","journal-title":"Can. J. Vet. Res."},{"key":"10.1016\/j.bmc.2013.03.052_b0065","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2174\/1386207053328101","volume":"8","author":"Tekwani","year":"2005","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.bmc.2013.03.052_b0070","first-page":"o2826","volume":"68","author":"Marciniec","year":"2012","journal-title":"Acta Cryst."},{"key":"10.1016\/j.bmc.2013.03.052_b0075","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1128\/AAC.32.11.1725","volume":"32","author":"Wright","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.03.052_b0080","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1128\/AAC.16.6.710","volume":"16","author":"Desjardins","year":"1979","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.03.052_b0085","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jinorgbio.2007.01.006","volume":"101","author":"Chemaly","year":"2007","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bmc.2013.03.052_b0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"Mosmann","year":"1983","journal-title":"Immunol. Methods"},{"key":"10.1016\/j.bmc.2013.03.052_b0095","first-page":"46","volume":"2011","author":"Hayat","year":"1897","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.052_b0100","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.2165\/00003495-200262140-00004","volume":"62","author":"Ulukan","year":"2002","journal-title":"Drugs"},{"key":"10.1016\/j.bmc.2013.03.052_h0140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1016\/j.bmc.2013.03.052_h0145","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.bmc.2013.03.052_h0150","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.052_h0155","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1021\/jm00378a021","volume":"27","author":"Andrews","year":"1984","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.052_h0160","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1021\/jm049661n","volume":"48","author":"Refsgaard","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.03.052_b0115","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/med.10041","volume":"23","author":"Muegge","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2013.03.052_b0120","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2013.03.052_b0125","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","volume":"234","author":"Sali","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2013.03.052_b0130","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Cryst."},{"key":"10.1016\/j.bmc.2013.03.052_b0135","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1016\/j.bmcl.2012.06.083","volume":"22","author":"Salahuddin","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.03.052_b0140","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/356083a0","volume":"5","author":"L\u00fcthy","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2013.03.052_b0145","doi-asserted-by":"crossref","first-page":"W407","DOI":"10.1093\/nar\/gkm290","volume":"35","author":"Wiederstein","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2013.03.052_b0150","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bmc.2013.03.052_b0155","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/protein\/8.2.127","volume":"8","author":"Wallace","year":"1995","journal-title":"Protein Eng."},{"key":"10.1016\/j.bmc.2013.03.052_b0160","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1128\/AAC.48.6.2214-2222.2004","volume":"48","author":"Korsinczky","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.03.052_b0165","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0035-9203(78)90144-X","volume":"72","author":"Diamond","year":"1978","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.bmc.2013.03.052_b0170","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1128\/AAC.22.2.342","volume":"22","author":"Gillin","year":"1982","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.03.052_b0175","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1055\/s-2007-969152","volume":"52","author":"Keene","year":"1986","journal-title":"Planta Med."},{"key":"10.1016\/j.bmc.2013.03.052_b0180","series-title":"SHELXL-97: An Integrated System for Solving and Refining Crystal Structures from Diffraction Data (Revision 5.1)","author":"Sheldrick","year":"1997"},{"key":"10.1016\/j.bmc.2013.03.052_b0185","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1073\/pnas.91.15.7149","volume":"91","author":"Triglia","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.03.052_b0190","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","volume":"18","author":"Guex","year":"1997","journal-title":"Electrophoresis"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613002745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613002745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:13:52Z","timestamp":1760832832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089613002745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":48,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0968089613002745"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.03.052","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and evaluation of 7-chloro-4-(piperazin-1-yl)quinoline-sulfonamide as hybrid antiprotozoal agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.03.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}