{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:25:37Z","timestamp":1789741537314,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21172181"],"award-info":[{"award-number":["21172181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81250110089"],"award-info":[{"award-number":["81250110089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81250110554"],"award-info":[{"award-number":["81250110554"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Fund for International Young Scientists from International (Regional) Cooperation and Exchange Program)","award":["CSTC2012jjB10026"],"award-info":[{"award-number":["CSTC2012jjB10026"]}]},{"name":"Key Program of Natural Science Foundation of Chongqing","award":["SRFDP 20110182110007"],"award-info":[{"award-number":["SRFDP 20110182110007"]}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"crossref","award":["XDJK2011D007"],"award-info":[{"award-number":["XDJK2011D007"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"crossref","award":["XDJK2012B026"],"award-info":[{"award-number":["XDJK2012B026"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Funds for the Central Universities"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.bmc.2013.05.007","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T01:46:13Z","timestamp":1368668773000},"page":"4158-4169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin"],"prefix":"10.1016","volume":"21","author":[{"given":"Ling","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Juan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guri L.V.","family":"Damu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Xia","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-He","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.05.007_b0010","unstructured":"Peng, X. M.; Cai, G. X.; Zhou, C. H. Curr. Top. Med. Chem. 2013, 13 (in press)."},{"key":"10.1016\/j.bmc.2013.05.007_b0015","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/092986712803414213","volume":"19","author":"Zhou","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0020","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.bmcl.2010.01.159","volume":"20","author":"Zhang","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.007_b0025","doi-asserted-by":"crossref","unstructured":"Zhang, L.; Peng, X.M.; Damu, G.L.V.; Geng, R.X.; Zhou, C.H. Med. Res. Rev. 2013, http:\/\/dx.doi.org\/10.1002\/med.21290.","DOI":"10.1002\/med.21290"},{"key":"10.1016\/j.bmc.2013.05.007_b0030","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.2174\/1381612811319210013","volume":"19","author":"Peng","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2013.05.007_b0035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ejmech.2013.03.049","volume":"64","author":"Zhang","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0040","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1021\/jm901378u","volume":"53","author":"Sutherland","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0045","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejmech.2010.10.015","volume":"46","author":"Khalaj","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0050","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1016\/j.bmc.2012.05.050","volume":"20","author":"Li","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0055","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.bmcl.2010.12.128","volume":"21","author":"Lee","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.007_b0060","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1016\/j.ejmech.2009.01.005","volume":"44","author":"Hernandez-Nunez","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0065","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2174\/187152011796817664","volume":"11","author":"Liu","year":"2011","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0070","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.bmc.2011.11.057","volume":"20","author":"Hu","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0075","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2165\/00003088-199223050-00002","volume":"23","author":"Lau","year":"1992","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.bmc.2013.05.007_b0080","first-page":"17","volume":"15","author":"Khabnadideh","year":"2007","journal-title":"DARU J. Pharm. Sci."},{"key":"10.1016\/j.bmc.2013.05.007_b0085","first-page":"313","volume":"3","author":"Trivedi","year":"2011","journal-title":"Chem. Pharm. Res."},{"key":"10.1016\/j.bmc.2013.05.007_b0090","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.1086\/651487","volume":"50","author":"Burman","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bmc.2013.05.007_b0095","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1021\/ml300362a","volume":"4","author":"Tukulula","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.007_b0100","first-page":"47","volume":"7","author":"Marriner","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0105","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1016\/j.bmc.2009.04.028","volume":"17","author":"Samosorn","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0110","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ejmech.2012.07.015","volume":"55","author":"Zhang","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0115","doi-asserted-by":"crossref","first-page":"8216","DOI":"10.1021\/jf2012584","volume":"59","author":"Kuo","year":"2011","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0120","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.ejmech.2011.01.016","volume":"46","author":"Bodiwala","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0125","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/med.20156","volume":"29","author":"Gautam","year":"2009","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2013.05.007_b0130","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1016\/j.bmcl.2011.01.101","volume":"21","author":"Bahar","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.007_b0135","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1128\/AAC.34.5.918","volume":"34","author":"Vennerstrom","year":"1990","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.05.007_b0140","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1016\/j.ejmech.2010.06.012","volume":"45","author":"Fang","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0145","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.bmcl.2007.01.061","volume":"17","author":"G\u00fcven","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.007_b0150","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.ejmech.2007.06.026","volume":"43","author":"Karegoudar","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0155","first-page":"e53499","volume":"8","author":"Agudelo","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2013.05.007_b0160","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ejmech.2011.12.002","volume":"48","author":"Belatik","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0165","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1016\/j.bmcl.2008.08.069","volume":"18","author":"Mallia","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.007_b0170","series-title":"Comprehensive Heterocyclic Chemistry","first-page":"345","author":"Grimmett","year":"1984"},{"key":"10.1016\/j.bmc.2013.05.007_b0175","first-page":"35","volume":"34","author":"Li","year":"2011","journal-title":"Chin. J. Exp. Propellan."},{"key":"10.1016\/j.bmc.2013.05.007_b0180","first-page":"7","volume":"3","author":"Zhang","year":"2003","journal-title":"J. China Pharm. Univ."},{"key":"10.1016\/j.bmc.2013.05.007_b0185","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0223-5234(96)85167-1","volume":"31","author":"Iwasal","year":"1996","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0190","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.1016\/j.bmc.2012.09.029","volume":"20","author":"Wang","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.007_b0225","unstructured":"National Committee for Clinical Laboratory Standards Approved standard Document, M27-A2, Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. National Committee for Clinical Laboratory Standards, Wayne, PA, 2002."},{"key":"10.1016\/j.bmc.2013.05.007_b0195","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1016\/j.bmcl.2011.05.042","volume":"21","author":"Zhang","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.007_b0200","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1021\/ie202005c","volume":"51","author":"Suryawanshi","year":"2012","journal-title":"Ind. Eng. Chem. Res."},{"key":"10.1016\/j.bmc.2013.05.007_b0205","series-title":"Principles of Fluorescence Spectroscopy","author":"Lakowicz","year":"2006"},{"key":"10.1016\/j.bmc.2013.05.007_b0210","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1021\/bi00793a015","volume":"10","author":"Lehrer","year":"1971","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2013.05.007_b0215","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1749-6632.1949.tb27297.x","volume":"51","author":"Scatchard","year":"1949","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.bmc.2013.05.007_b0220","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jphotobiol.2011.01.006","volume":"103","author":"Mote","year":"2011","journal-title":"J. Photochem. Photobiol., B"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961300432X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961300432X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:14:47Z","timestamp":1760832887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808961300432X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":44,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S096808961300432X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.05.007","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and bioactive evaluation of novel hybrids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human serum albumin","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}