{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:54:00Z","timestamp":1788872040033,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Academy of Finland, Sigrid Jus\u00e9lius Foundation and Competitive Research Funding of Tampere University Hospital"},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento Pessoal de N\u00edvel Superior (CAPES), Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.bmc.2013.05.058","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T05:37:27Z","timestamp":1370497047000},"page":"4472-4476","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Anion inhibition studies of the \u03b1-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease"],"prefix":"10.1016","volume":"21","author":[{"given":"Peiwen","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alane Beatriz","family":"Vermelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Parkkila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemente","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.05.058_b0005","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2013.05.058_b0010","doi-asserted-by":"crossref","first-page":"30766","DOI":"10.1074\/jbc.M805353200","volume":"283","author":"Domsic","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0015","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nature Rev. Drug Discov."},{"key":"10.1016\/j.bmc.2013.05.058_b0020","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fphar.2011.00034","volume":"2","author":"Supuran","year":"2011","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bmc.2013.05.058_b0025","doi-asserted-by":"crossref","first-page":"6683","DOI":"10.1074\/jbc.M311648200","volume":"279","author":"Tripp","year":"2004","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0030","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature06636","volume":"452","author":"Xu","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2013.05.058_b0035","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1073\/pnas.0908301106","volume":"106","author":"Alterio","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bmc.2013.05.058_b0040","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nature Rev. Drug Discov."},{"key":"10.1016\/j.bmc.2013.05.058_b0045","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jmb.2008.11.037","volume":"385","author":"Schlicker","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2013.05.058_b0050","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1074\/jbc.M414348200","volume":"280","author":"Suarez Covarrubias","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0055","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1021\/ja010301o","volume":"123","author":"Tu","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2013.05.058_b0060","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1074\/jbc.M510756200","volume":"281","author":"Covarrubias","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0065","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.058_b0070","first-page":"243","volume":"19","author":"Burghout","year":"2011","journal-title":"Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0075","first-page":"1172","volume":"19","author":"Joseph","year":"2011","journal-title":"Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0080","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1021\/jm901855h","volume":"53","author":"Joseph","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0085","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/jm0512600","volume":"49","author":"Nishimori","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0090","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1021\/jm9003126","volume":"52","author":"Nishimori","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0095","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.2174\/138161210793429797","volume":"16","author":"Supuran","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2013.05.058_b0100","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2013.05.058_b0105","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1016\/j.bmcl.2010.02.042","volume":"20","author":"Vullo","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.058_b0110","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.2174\/138161210793429850","volume":"16","author":"Winum","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2013.05.058_b0115","doi-asserted-by":"crossref","first-page":"909","DOI":"10.2174\/156802607780636744","volume":"7","author":"Krungkrai","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0120","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1016\/j.bmcl.2008.09.030","volume":"18","author":"Krungkrai","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.058_b0125","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2174\/138161208783877901","volume":"14","author":"Krungkrai","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2013.05.058_b0130","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1021\/jm4000616","volume":"56","author":"Pan","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0135","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jinorgbio.2011.11.017","volume":"111","author":"De Simone","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bmc.2013.05.058_b0140","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0145","first-page":"19","volume":"2009","author":"Innocenti","year":"1855","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.058_b0150","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.bmcl.2010.01.081","volume":"20","author":"Innocenti","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.058_b0155","doi-asserted-by":"crossref","first-page":"895","DOI":"10.3109\/14756366.2011.554415","volume":"26","author":"Kolayli","year":"2011","journal-title":"J. Enzyme Inhib Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0160","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jinorgbio.2012.02.009","volume":"110","author":"Maresca","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bmc.2013.05.058_b0165","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3109\/14756366.2011.570759","volume":"26","author":"Ozensoy","year":"2011","journal-title":"J. Enzyme Inhib Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0170","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.bmcl.2009.11.124","volume":"20","author":"Temperini","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.05.058_h0175","doi-asserted-by":"crossref","first-page":"10742","DOI":"10.1021\/jm301611m","volume":"55","author":"Del Prete","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_h0180","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1517\/13543776.2013.778245","volume":"23","author":"Capasso","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2013.05.058_b0180","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.bmc.2012.01.007","volume":"20","author":"Ohradanova","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0185","first-page":"48","volume":"2012","author":"Carta","year":"1868","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmc.2013.05.058_b0190","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/14756366.2011.641015","volume":"28","author":"Maresca","year":"2013","journal-title":"J. Enzyme Inhib Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0195","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1021\/jm300031j","volume":"55","author":"Carta","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.05.058_b0200","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","volume":"27","author":"Supuran","year":"2012","journal-title":"J. Enzyme Inhib Med. Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613005075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613005075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:10:48Z","timestamp":1760832648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089613005075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":41,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0968089613005075"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.05.058","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anion inhibition studies of the \u03b1-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.05.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}