{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:34:43Z","timestamp":1791920083858,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"IRCCS Centro Neurolesi \u201cBonino-Pulejo\u201d, Messina"},{"name":"Institute of Experimental Zooprophylaxy of Sicily \u201cA. Mirri\u201d, Palermo, Italy"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.bmc.2013.05.065","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T15:32:38Z","timestamp":1370964758000},"page":"5532-5547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Anti-inflammatory and anti-apoptotic effects of (R)-glucoraphanin bioactivated with myrosinase in murine sub-acute and acute MPTP-induced Parkinson\u2019s disease"],"prefix":"10.1016","volume":"21","author":[{"given":"Maria","family":"Galuppo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Iori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina Rosalinda","family":"De Nicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Placido","family":"Bramanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Mazzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.05.065_b0005","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1056\/NEJM199810083391506","volume":"339","author":"Lang","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bmc.2013.05.065_b0010","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1212\/WNL.52.7.1417","volume":"52","author":"Saunders-Pullman","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.bmc.2013.05.065_b0015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00005072-199603000-00001","volume":"55","author":"Forno","year":"1996","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bmc.2013.05.065_b0020","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00441-004-0975-6","volume":"318","author":"Klockgether","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bmc.2013.05.065_b0025","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4161\/auto.5604","volume":"4","author":"Engelender","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.bmc.2013.05.065_b0030","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1093\/brain\/aws211","volume":"135","author":"Colloby","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.bmc.2013.05.065_b0035","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1248\/bpb.b12-00127","volume":"35","author":"Kim","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bmc.2013.05.065_b0040","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1002\/ana.10483","volume":"53","author":"Jenner","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bmc.2013.05.065_b0045","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.molbrainres.2005.01.012","volume":"134","author":"Shimoji","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.bmc.2013.05.065_b0050","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1111\/j.1460-9568.2006.05192.x","volume":"24","author":"Anderson","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bmc.2013.05.065_b0055","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.neuro.2008.02.007","volume":"29","author":"He","year":"2008","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bmc.2013.05.065_b0060","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.phytochem.2012.02.005","volume":"77","author":"Agerbirk","year":"2012","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2013.05.065_b0065","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/(SICI)1097-0290(20000620)68:6<660::AID-BIT9>3.0.CO;2-L","volume":"68","author":"Leoni","year":"2000","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.bmc.2013.05.065_b0070","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bmc.2013.05.065_b0075","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00394-008-2009-8","volume":"47","author":"Hayes","year":"2008","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.bmc.2013.05.065_b0080","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1002\/ijc.25620","volume":"128","author":"Abdull Razis","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bmc.2013.05.065_b0085","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tox.2010.08.080","volume":"277","author":"Abdull Razis","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.bmc.2013.05.065_b0090","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.bmc.2013.05.065_b0095","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1600-0625.2009.00928.x","volume":"19","author":"Wagner","year":"2010","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bmc.2013.05.065_b0100","unstructured":"EEC Regulation 1864\/90, Enclosure VIII, 1990."},{"key":"10.1016\/j.bmc.2013.05.065_b0105","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0003-9861(90)90346-Z","volume":"280","author":"Pessina","year":"1990","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bmc.2013.05.065_b0110","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.lungcan.2010.06.015","volume":"71","author":"Abdull Razis","year":"2011","journal-title":"Lung Cancer"},{"key":"10.1016\/j.bmc.2013.05.065_b0115","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1073\/pnas.97.16.9287","volume":"97","author":"Feng","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.05.065_b0120","first-page":"435","volume":"50","author":"Ogawa","year":"1985","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.bmc.2013.05.065_b0125","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/ana.410410417","volume":"41","author":"Miller","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bmc.2013.05.065_b0130","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1756-6606-2-10","volume":"2","author":"Zhang","year":"2009","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bmc.2013.05.065_b0135","doi-asserted-by":"crossref","first-page":"450","DOI":"10.2174\/187152712800792910","volume":"11","author":"Feve","year":"2012","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"key":"10.1016\/j.bmc.2013.05.065_b0140","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.4049\/jimmunol.1000208","volume":"185","author":"Chung","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.bmc.2013.05.065_b0145","first-page":"1037","volume":"1","author":"Selley","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.bmc.2013.05.065_b0150","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev.physiol.64.081501.160008","volume":"64","author":"Nimchinsky","year":"2002","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bmc.2013.05.065_b0155","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1460-9568.2010.07117.x","volume":"31","author":"Bezard","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bmc.2013.05.065_b0160","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1016\/j.fct.2012.05.030","volume":"50","author":"Canistro","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bmc.2013.05.065_b0165","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1207\/s15327914nc5201_7","volume":"52","author":"Laso","year":"2005","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.bmc.2013.05.065_b0170","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/01635580701308257","volume":"58","author":"Mas","year":"2007","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.bmc.2013.05.065_b0175","first-page":"845618","volume":"2012","author":"Blesa","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bmc.2013.05.065_b0180","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1089\/ars.2010.3849","volume":"16","author":"Thomas","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bmc.2013.05.065_b0185","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1046\/j.1471-4159.2000.0742213.x","volume":"74","author":"Dehmer","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bmc.2013.05.065_b0190","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1523\/JNEUROSCI.3309-03.2004","volume":"24","author":"Furuya","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bmc.2013.05.065_b0195","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/exnr.1998.6993","volume":"156","author":"Kurkowska-Jastrzebska","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bmc.2013.05.065_b0200","first-page":"1457","volume":"51","author":"Lesemann","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.bmc.2013.05.065_b0205","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/1097-4547(20010301)63:5<402::AID-JNR1035>3.0.CO;2-F","volume":"63","author":"Shimoke","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bmc.2013.05.065_b0210","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1124\/jpet.103.049445","volume":"306","author":"Murray","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2013.05.065_b0215","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1046\/j.1471-4159.2003.02210.x","volume":"88","author":"Dehmer","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bmc.2013.05.065_b0220","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/ana.20089","volume":"55","author":"Nutt","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bmc.2013.05.065_b0225","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2967\/jnumed.111.101436","volume":"53","author":"Sossi","year":"2012","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.bmc.2013.05.065_b0230","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.1016\/S1353-8020(11)70064-5","volume":"18","author":"Phani","year":"2012","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.bmc.2013.05.065_b0235","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/00005072-199804000-00006","volume":"57","author":"Good","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bmc.2013.05.065_b0240","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbrc.2010.11.117","volume":"404","author":"Pal","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmc.2013.05.065_b0245","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.freeradbiomed.2008.10.040","volume":"46","author":"Harvey","year":"2009","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.bmc.2013.05.065_b0250","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/glia.20947","volume":"58","author":"Rojo","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.bmc.2013.05.065_b0255","doi-asserted-by":"crossref","first-page":"10507","DOI":"10.1523\/JNEUROSCI.1494-12.2012","volume":"32","author":"Lapash Daniels","year":"2012","journal-title":"J. Neurosci."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613005348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613005348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:16:10Z","timestamp":1760832970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089613005348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":51,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0968089613005348"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.05.065","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory and anti-apoptotic effects of (RS)-glucoraphanin bioactivated with myrosinase in murine sub-acute and acute MPTP-induced Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.05.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}