{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:42:33Z","timestamp":1760834553010,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.bmc.2013.06.008","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T17:02:09Z","timestamp":1371142929000},"page":"5461-5469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Solid-phase synthesis of 5\u2032-triphosphate 2\u2032-5\u2032-oligoadenylates analogs with 3\u2032-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs"],"prefix":"10.1016","volume":"21","author":[{"given":"Yann","family":"Thillier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah K.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christabel","family":"Moy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Jacques","family":"Vasseur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonid","family":"Beigelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Debart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.06.008_b0005","first-page":"258","volume":"147","author":"Isaacs","year":"1957","journal-title":"Proc. R. Soc. B."},{"key":"10.1016\/j.bmc.2013.06.008_b0010","doi-asserted-by":"crossref","first-page":"12720","DOI":"10.1128\/JVI.01471-07","volume":"81","author":"Silverman","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.bmc.2013.06.008_b0015","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1073\/pnas.75.1.256","volume":"75","author":"Kerr","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.06.008_b0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0163-7258(97)00167-8","volume":"78","author":"Player","year":"1998","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bmc.2013.06.008_b0025","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cytogfr.2007.06.012","volume":"18","author":"Silverman","year":"2007","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bmc.2013.06.008_b0030","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.biochi.2007.02.006","volume":"89","author":"Bisbal","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.bmc.2013.06.008_b0035","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2174\/0929867013372445","volume":"8","author":"Adah","year":"2001","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2013.06.008_b0040","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.bmcl.2009.12.005","volume":"20","author":"Nagaoka","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.06.008_b0045","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bmcl.2011.11.040","volume":"22","author":"Pav","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.06.008_b0050","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1002\/cmdc.200700150","volume":"2","author":"Morita","year":"2007","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2013.06.008_b0055","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1016\/j.bmcl.2004.06.071","volume":"14","author":"Ueno","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.06.008_b0060","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1021\/bi00462a017","volume":"29","author":"Charachon","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2013.06.008_b0065","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1093\/nar\/23.19.3989","volume":"23","author":"Beigelman","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2013.06.008_b0070","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1021\/jm050401v","volume":"49","author":"Pav","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.06.008_b0075","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/cbdv.201000288","volume":"8","author":"Kiuru","year":"2011","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bmc.2013.06.008_b0080","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/cbdv.201100144","volume":"9","author":"Kiuru","year":"2012","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bmc.2013.06.008_b0085","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/j.1460-2075.1985.tb03647.x","volume":"4","author":"Watling","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.bmc.2013.06.008_b0090","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1021\/bi00396a041","volume":"26","author":"Suhadolnik","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2013.06.008_b0095","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1038\/sj.emboj.7600420","volume":"23","author":"Tanaka","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bmc.2013.06.008_b0100","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.2174\/092986706779010270","volume":"13","author":"Poijarvi-Virta","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2013.06.008_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/bioo.1995.1001","volume":"23","author":"Iyer","year":"1995","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bmc.2013.06.008_b0110","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1039\/b903331a","author":"Zhang","year":"2009","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmc.2013.06.008_b0115","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1093\/nar\/gki657","volume":"33","author":"Grajkowski","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2013.06.008_b0120","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.tet.2009.10.096","volume":"66","author":"Aus\u00edn","year":"2010","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2013.06.008_b0125","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1093\/nar\/27.20.4071","volume":"27","author":"Viv\u00e8s","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2013.06.008_b0130","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1021\/jo300648u","volume":"77","author":"Lietard","year":"2012","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.06.008_b0135","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1093\/nar\/26.9.2069","volume":"26","author":"Tosquellas","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2013.06.008_b0140","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1021\/ol0616182","volume":"8","author":"Parey","year":"2006","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmc.2013.06.008_b0145","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1016\/j.bmcl.2009.06.015","volume":"19","author":"Martin","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.06.008_b0150","doi-asserted-by":"crossref","first-page":"5719","DOI":"10.1021\/jo200826h","volume":"76","author":"Lavergne","year":"2011","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.06.008_b0155","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1016\/j.bmcl.2011.04.073","volume":"21","author":"Johnsson","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.06.008_b0160","doi-asserted-by":"crossref","first-page":"9135","DOI":"10.1002\/chem.200801392","volume":"14","author":"Lavergne","year":"2008","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.bmc.2013.06.008_b0165","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1021\/ol1004214","volume":"12","author":"Zlatev","year":"2010","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmc.2013.06.008_b0170","unstructured":"Kempe, T. U.S. Patent 5,750,672, 1998."},{"key":"10.1016\/j.bmc.2013.06.008_b0175","doi-asserted-by":"crossref","first-page":"11540","DOI":"10.1021\/ja201561z","volume":"133","author":"Dellinger","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2013.06.008_b0180","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1093\/nar\/18.13.3813","volume":"18","author":"Damha","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2013.06.008_b0185","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1093\/nar\/25.18.3629","volume":"25","author":"Pon","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2013.06.008_b0190","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1002\/cbic.201200400","volume":"13","author":"Preus","year":"2012","journal-title":"ChemBioChem"},{"key":"10.1016\/j.bmc.2013.06.008_b0195","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1128\/JCM.02184-10","volume":"49","author":"Chen","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.bmc.2013.06.008_b0200","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1128\/JCM.40.9.3256-3260.2002","volume":"40","author":"Spackman","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.bmc.2013.06.008_b0205","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1128\/AAC.00211-07","volume":"51","author":"Chapman","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.06.008_b0210","doi-asserted-by":"crossref","first-page":"8874","DOI":"10.1073\/pnas.95.15.8874","volume":"95","author":"Player","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613005397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613005397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:15:12Z","timestamp":1760832912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089613005397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":42,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0968089613005397"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.06.008","relation":{},"ISSN":["0968-0896"],"issn-type":[{"type":"print","value":"0968-0896"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Solid-phase synthesis of 5\u2032-triphosphate 2\u2032-5\u2032-oligoadenylates analogs with 3\u2032-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}