{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:26:24Z","timestamp":1776723984981,"version":"3.51.2"},"reference-count":24,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.bmc.2013.06.057","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T20:46:56Z","timestamp":1372798016000},"page":"5907-5922","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors"],"prefix":"10.1016","volume":"21","author":[{"given":"Yutaka","family":"Mori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppei","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shojiro","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Tamaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Nagayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahide","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.06.057_b0005","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","volume":"365","author":"Kearney","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2013.06.057_b0010","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/291329a0","volume":"291","author":"MacGregor","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2013.06.057_b0015","first-page":"181","volume":"2","author":"Hershey","year":"2005","journal-title":"Drug Discovery Today: Ther. Strat."},{"key":"10.1016\/j.bmc.2013.06.057_b0020","first-page":"239","volume":"Vol. 4","author":"Tice","year":"2010"},{"key":"10.1016\/j.bmc.2013.06.057_b0025","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S1074-5521(00)00134-4","volume":"7","author":"Rahuel","year":"2000","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmc.2013.06.057_b0030","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1021\/jm900022f","volume":"52","author":"Bezen\u00e7on","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.06.057_b0035","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1021\/ml200137x","volume":"2","author":"Jia","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.06.057_b0040","doi-asserted-by":"crossref","first-page":"7677","DOI":"10.1016\/j.bmcl.2012.09.103","volume":"22","author":"Mori","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.06.057_b0045","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1021\/ml300168e","volume":"3","author":"Nakamura","year":"2012","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.06.057_b0050","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1016\/j.bmc.2013.03.022","volume":"21","author":"Nakamura","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.06.057_b0055","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1073\/pnas.89.16.7806","volume":"89","author":"Ganten","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.06.057_b0060","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-827X(01)01004-7","volume":"56","author":"M\u00e4rki","year":"2001","journal-title":"IL Farmaco"},{"key":"10.1016\/j.bmc.2013.06.057_h0065","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0006-291X(03)01451-7","volume":"308","author":"Wood","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmc.2013.06.057_h0070","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00004872-200502000-00025","volume":"23","author":"Wood","year":"2005","journal-title":"J. Hypertens."},{"key":"10.1016\/j.bmc.2013.06.057_h0075","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1161\/01.HYP.0000179573.91016.3f","volume":"46","author":"Pilz","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.bmc.2013.06.057_h0080","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1021\/jm070316i","volume":"50","author":"Maibaum","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.06.057_b0070","unstructured":"Ehara, T.; Grosche, P.; Irie, O.; Iwaki, Y.; Kanazawa, T.; Kawakami, S.; Konishi, K.; Mogi, M.; Suzuki, M.; Yokokawa, F. WO2007\/077005, 2007; PCT Int. Appl."},{"key":"10.1016\/j.bmc.2013.06.057_b0075","doi-asserted-by":"crossref","first-page":"7872","DOI":"10.1002\/anie.200801636","volume":"47","author":"Oh","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bmc.2013.06.057_b0080","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1016\/0040-4039(95)01316-A","volume":"36","author":"Fukuyama","year":"1995","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2013.06.057_b0085","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1021\/jm049339c","volume":"48","author":"Lowe","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.06.057_b0090","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1021\/jo0609834","volume":"71","author":"Colyer","year":"2006","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.06.057_b0095","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1016\/j.bmcl.2011.02.067","volume":"21","author":"Aspiotis","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.06.057_b0100","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1016\/j.bmcl.2011.06.043","volume":"21","author":"Yuan","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.06.057_b0105","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1016\/j.bmcl.2012.05.092","volume":"22","author":"Nakamura","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961300597X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961300597X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:12:59Z","timestamp":1760832779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808961300597X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":24,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S096808961300597X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.06.057","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.06.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}