{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:08:48Z","timestamp":1782774528825,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.bmc.2013.08.068","type":"journal-article","created":{"date-parts":[[2013,9,7]],"date-time":"2013-09-07T13:00:59Z","timestamp":1378558859000},"page":"6274-6281","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis of sterically encumbered 11\u03b2-aminoprogesterone derivatives and evaluation as 11\u03b2-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists"],"prefix":"10.1016","volume":"21","author":[{"given":"Keyur","family":"Pandya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Seibert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Vederas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Odermatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.08.068_b0005","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0083-6729(08)60646-9","volume":"57","author":"Stewart","year":"1999","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.bmc.2013.08.068_b0010","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.mce.2011.07.020","volume":"350","author":"Odermatt","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bmc.2013.08.068_b0015","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1126\/science.1066285","volume":"294","author":"Masuzaki","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bmc.2013.08.068_b0020","doi-asserted-by":"crossref","first-page":"7088","DOI":"10.1073\/pnas.0305524101","volume":"101","author":"Paterson","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.08.068_b0025","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0140-6736(87)91014-2","volume":"2","author":"Stewart","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2013.08.068_b0030","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/ki.2009.269","volume":"76","author":"Farese","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.bmc.2013.08.068_b0035","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.bmc.2011.02.005","volume":"19","author":"Gaware","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0040","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bmc.2009.10.036","volume":"18","author":"Beseda","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0045","doi-asserted-by":"crossref","first-page":"7522","DOI":"10.1016\/j.bmc.2010.08.046","volume":"18","author":"Stanetty","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jsbmb.2010.12.019","volume":"125","author":"Kratschmar","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bmc.2013.08.068_b0055","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","volume":"348","author":"Pitt","year":"2003","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmc.2013.08.068_b0060","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","volume":"341","author":"Pitt","year":"1999","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmc.2013.08.068_b0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1009492","volume":"364","author":"Zannad","year":"2011","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmc.2013.08.068_b0070","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/ki.2011.48","volume":"79","author":"Bertocchio","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.bmc.2013.08.068_b0075","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1097\/01.hjh.0000249708.44016.5c","volume":"24","author":"van den Meiracker","year":"2006","journal-title":"J. Hypertens."},{"key":"10.1016\/j.bmc.2013.08.068_b0080","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1161\/01.HYP.0000044937.95080.E9","volume":"41","author":"Sato","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.bmc.2013.08.068_b0085","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1210\/endo.136.4.7895695","volume":"136","author":"Souness","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.bmc.2013.08.068_b0090","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1124\/mol.62.6.1306","volume":"62","author":"Rafestin-Oblin","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmc.2013.08.068_b0095","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s11906-007-0020-8","volume":"9","author":"Funder","year":"2007","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.bmc.2013.08.068_b0100","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2174\/092986706776055562","volume":"13","author":"Salunke","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0105","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/BF00844694","volume":"127","author":"Szendi","year":"1996","journal-title":"Monatsh. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/jps.2600530421","volume":"53","author":"Lange","year":"1964","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bmc.2013.08.068_b0115","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jsbmb.2007.03.020","volume":"104","author":"Morris","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bmc.2013.08.068_b0120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.steroids.2003.09.009","volume":"69","author":"Lecomte","year":"2004","journal-title":"Steroids"},{"key":"10.1016\/j.bmc.2013.08.068_b0125","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1021\/jo01343a008","volume":"31","author":"Rausser","year":"1966","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0130","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1021\/jo01343a007","volume":"31","author":"Rausser","year":"1966","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0135","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1021\/bc300378e","volume":"23","author":"Dao","year":"2012","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0140","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/hlca.19770600213","volume":"60","author":"Loibner","year":"1977","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.bmc.2013.08.068_b0145","doi-asserted-by":"crossref","first-page":"9671","DOI":"10.1016\/S0040-4020(01)85535-6","volume":"50","author":"Afonso","year":"1994","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2013.08.068_b0150","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1021\/jm051114u","volume":"49","author":"Salunke","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0155","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1055\/s-2000-6389","author":"Fringuelli","year":"2000","journal-title":"Synthesis"},{"key":"10.1016\/j.bmc.2013.08.068_b0160","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1021\/jo00132a032","volume":"47","author":"Ottenheijm","year":"1982","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0165","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1039\/b513409a","volume":"3","author":"Diaper","year":"2005","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0170","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1021\/ol701742x","volume":"9","author":"Liu","year":"2007","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmc.2013.08.068_b0175","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1021\/jo010456e","volume":"67","author":"Chhabra","year":"2002","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0180","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0039-128X(96)00244-9","volume":"62","author":"Galigniana","year":"1997","journal-title":"Steroids"},{"key":"10.1016\/j.bmc.2013.08.068_b0185","series-title":"Organic Reactions","author":"Wolff","year":"1959"},{"key":"10.1016\/j.bmc.2013.08.068_b0190","doi-asserted-by":"crossref","first-page":"28762","DOI":"10.1074\/jbc.274.40.28762","volume":"274","author":"Odermatt","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0195","doi-asserted-by":"crossref","first-page":"28484","DOI":"10.1074\/jbc.M100374200","volume":"276","author":"Odermatt","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.08.068_b0200","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/1742-2094-9-260","volume":"9","author":"Chantong","year":"2012","journal-title":"J. Neuroinflamm."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613007712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613007712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:18:07Z","timestamp":1760833087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089613007712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":40,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0968089613007712"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.08.068","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of sterically encumbered 11\u03b2-aminoprogesterone derivatives and evaluation as 11\u03b2-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.08.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}