{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:50:01Z","timestamp":1788871801423,"version":"build-2803163510"},"reference-count":21,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["ROP-53171"],"award-info":[{"award-number":["ROP-53171"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"College of Graduate Studies and Research"},{"DOI":"10.13039\/100008920","name":"University of Saskatchewan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008920","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Dean\u2019s scholarship"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.bmc.2013.09.065","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T16:32:30Z","timestamp":1381249950000},"page":"7250-7256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["3,5-Bis(benzylidene)-4-piperidones and related N-acyl analogs: A novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum"],"prefix":"10.1016","volume":"21","author":[{"given":"Umashankar","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi S.P.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Alcorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Hickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Sciotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Leed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Roncal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Dimmock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.09.065_b0005","author":"World Malaria Report","year":"2012"},{"key":"10.1016\/j.bmc.2013.09.065_b0010","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.bmcl.2012.10.126","volume":"23","author":"Singh","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.09.065_b0015","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejmech.2006.08.002","volume":"42","author":"Das","year":"2007","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.09.065_b0020","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pt.2009.12.002","volume":"26","author":"Nzila","year":"2010","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.bmc.2013.09.065_b0025","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1128\/AAC.00308-09","volume":"53","author":"Kiara","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.09.065_b0030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0014-5793(98)00031-3","volume":"442","author":"Farber","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmc.2013.09.065_b0035","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1515\/BC.2002.086","volume":"383","author":"Harwaldt","year":"2002","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bmc.2013.09.065_b0040","series-title":"Drug-Like Properties: Concepts, Structure Design and Methods: From ADME to Toxicity Optimization","author":"Kerns","year":"2008"},{"key":"10.1016\/j.bmc.2013.09.065_b0045","series-title":"Exploring QSAR Hydrophobic, Electronic and Steric Constants","author":"Hansch","year":"1995"},{"key":"10.1016\/j.bmc.2013.09.065_b0050","series-title":"Exploring QSAR Hydrophobic, Electronic and Steric Constants","author":"Hansch","year":"1995"},{"key":"10.1016\/j.bmc.2013.09.065_b0055","series-title":"Exploring QSAR Hydrophobic, Electronic and Steric Constants","author":"Hansch","year":"1995"},{"key":"10.1016\/j.bmc.2013.09.065_b0060","series-title":"Drug-Like Properties: Concepts, Structure Design and Methods: From ADME to Toxicity Optimization","author":"Kerns","year":"2008"},{"key":"10.1016\/j.bmc.2013.09.065_b0065","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1128\/AAC.01607-06","volume":"51","author":"Johnson","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.09.065_b0070","unstructured":"GraphPad Software Inc., San Diego, USA."},{"key":"10.1016\/j.bmc.2013.09.065_b0075","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.molbiopara.2005.09.007","volume":"145","author":"Janse","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.bmc.2013.09.065_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0005361","volume":"4","author":"Ploeman","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2013.09.065_b0085","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2307\/3281779","volume":"70","author":"Ozaki","year":"1984","journal-title":"J. Parasitol."},{"key":"10.1016\/j.bmc.2013.09.065_b0090","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0022-1759(90)90187-Z","volume":"131","author":"Ferrari","year":"1990","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.bmc.2013.09.065_b0095","first-page":"345","volume":"51","author":"Owen","year":"2001","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.bmc.2013.09.065_b0100","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10822-005-8694-y","volume":"19","author":"Tetko","year":"2005","journal-title":"J. Comput. Aid. Mol. Des."},{"key":"10.1016\/j.bmc.2013.09.065_b0105","unstructured":"IBM SPSS statistics, version 20, release 20.0.0."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613008547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613008547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:14:47Z","timestamp":1760832887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089613008547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":21,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0968089613008547"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.09.065","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3,5-Bis(benzylidene)-4-piperidones and related N-acyl analogs: A novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.09.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}