{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T10:52:17Z","timestamp":1762685537438,"version":"build-2065373602"},"reference-count":63,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.bmc.2013.10.050","type":"journal-article","created":{"date-parts":[[2013,11,9]],"date-time":"2013-11-09T03:00:59Z","timestamp":1383966059000},"page":"559-576","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues"],"prefix":"10.1016","volume":"22","author":[{"given":"Donald A.","family":"Patrick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislav A.","family":"Bakunov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana M.","family":"Bakunova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Wenzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reto","family":"Brun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard R.","family":"Tidwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.10.050_b0005","unstructured":"http:\/\/www.who.int\/mediacentre\/factsheets\/fs259\/en\/. Accessed 1 May 2013."},{"key":"10.1016\/j.bmc.2013.10.050_b0010","unstructured":"http:\/\/www.who.int\/trypanosomiasis_african\/country\/risk_AFRO\/en\/. Accessed 1 May 2013."},{"key":"10.1016\/j.bmc.2013.10.050_b0015","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijantimicag.2011.03.004","volume":"38","author":"Astelbauer","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bmc.2013.10.050_b0020","series-title":"Manson\u2019s Tropical Diseases","first-page":"1307","author":"Burri","year":"2009"},{"key":"10.1016\/j.bmc.2013.10.050_b0025","unstructured":"http:\/\/www.who.int\/mediacentre\/factsheets\/fs094\/en\/index.html. Accessed 2 May 2013."},{"key":"10.1016\/j.bmc.2013.10.050_b0030","unstructured":"http:\/\/www.who.int\/gho\/malaria\/en\/index.html. Accessed 1 May 2013."},{"key":"10.1016\/j.bmc.2013.10.050_b0035","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ijantimicag.2012.12.007","volume":"41","author":"Klein","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bmc.2013.10.050_b0040","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2174\/138161213804070302","volume":"19","author":"Noedl","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2013.10.050_b0045","first-page":"876","volume":"11","author":"Paine","year":"2010","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"10.1016\/j.bmc.2013.10.050_b0050","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1021\/jm00214a014","volume":"20","author":"Das","year":"1977","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0055","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1016\/S0960-894X(96)00557-4","volume":"6","author":"Boykin","year":"1996","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.10.050_b0060","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1124\/dmd.105.005017","volume":"33","author":"Saulter","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bmc.2013.10.050_b0065","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1124\/dmd.106.010587","volume":"34","author":"Wang","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bmc.2013.10.050_b0070","first-page":"1086","volume":"6","author":"Yeates","year":"2003","journal-title":"IDrugs"},{"key":"10.1016\/j.bmc.2013.10.050_b0075","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1086\/430928","volume":"192","author":"Yeramian","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bmc.2013.10.050_b0080","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1017\/S0031182010001137","volume":"137","author":"Burri","year":"2010","journal-title":"Parasitology"},{"key":"10.1016\/j.bmc.2013.10.050_b0085","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/toxsci\/kfs238","volume":"130","author":"Harrill","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bmc.2013.10.050_b0090","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1021\/jm0302602","volume":"46","author":"Ismail","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0095","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1021\/jm400508e","volume":"56","author":"Patrick","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0100","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1021\/jm901178d","volume":"53","author":"Bakunov","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0105","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0223-5234(97)89640-7","volume":"32","author":"Boykin","year":"1997","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0110","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1016\/j.bmc.2010.03.058","volume":"18","author":"Branowska","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0115","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/jlac.197519750115","author":"Dann","year":"1975","journal-title":"Liebigs Ann. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0120","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1021\/jm00219a023","volume":"20","author":"Das","year":"1977","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0125","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/0223-5234(96)83970-5","volume":"31","author":"Kumar","year":"1996","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0130","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0223-5234(96)88214-6","volume":"30","author":"Kumar","year":"1995","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0135","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ejmech.2013.06.033","volume":"67","author":"Patrick","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0140","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1021\/jm0612867","volume":"50","author":"Patrick","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0145","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3987\/COM-03-9716","volume":"60","author":"Anbazhagan","year":"2003","journal-title":"Heterocycles"},{"key":"10.1016\/j.bmc.2013.10.050_b0150","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1021\/jm030604o","volume":"47","author":"Ansede","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0155","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0960-894X(02)00129-4","volume":"12","author":"Reiner","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.10.050_b0160","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1021\/jm070018l","volume":"50","author":"Bunnelle","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0165","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.bmc.2003.11.027","volume":"12","author":"Ramachandran","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0170","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1021\/jo000997o","volume":"66","author":"Roesch","year":"2001","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0175","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1021\/jo971572d","volume":"63","author":"Bleicher","year":"1998","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0180","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0020-1693(94)03881-3","volume":"220","author":"Nguyen","year":"1994","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.bmc.2013.10.050_b0185","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1021\/jm960652r","volume":"40","author":"Blackburn","year":"1997","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0190","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/jlac.1995199509231","author":"Dulog","year":"1995","journal-title":"Liebigs Ann."},{"key":"10.1016\/j.bmc.2013.10.050_b0195","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.bmc.2009.12.011","volume":"18","author":"Farahat","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0200","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.1016\/j.bmcl.2011.08.073","volume":"21","author":"Leclerc","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.10.050_b0205","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1021\/jo952164h","volume":"61","author":"Riesgo","year":"1996","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0210","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/00397918908050984","volume":"19","author":"Katz","year":"1989","journal-title":"Synth. Commun."},{"key":"10.1016\/j.bmc.2013.10.050_b0215","doi-asserted-by":"crossref","first-page":"9908","DOI":"10.1016\/j.tet.2005.06.061","volume":"61","author":"Hatsuda","year":"2005","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2013.10.050_b0220","first-page":"235","author":"Scott","year":"2011","journal-title":"PCT Int. Appl."},{"key":"10.1016\/j.bmc.2013.10.050_b0225","first-page":"376","author":"Wityak","year":"1995","journal-title":"PCT Int. Appl."},{"key":"10.1016\/j.bmc.2013.10.050_b0230","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1016\/0040-4039(96)00694-6","volume":"37","author":"Zhang","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2013.10.050_b0235","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1016\/S0960-894X(97)10081-6","volume":"7","author":"Quan","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.10.050_b0240","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1021\/jo01307a039","volume":"45","author":"Liu","year":"1980","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0245","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1039\/p19940000413","author":"Moriya","year":"1994","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"10.1016\/j.bmc.2013.10.050_b0250","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/md8010047","volume":"8","author":"Orhan","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bmc.2013.10.050_b0255","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1128\/AAC.00225-09","volume":"53","author":"Wenzler","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.10.050_b0260","doi-asserted-by":"crossref","first-page":"5763","DOI":"10.1021\/jm9006406","volume":"52","author":"Bakunov","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0265","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.1021\/jm800918v","volume":"51","author":"Bakunov","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0270","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1021\/jm801547t","volume":"52","author":"Bakunova","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0275","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1021\/jm0708634","volume":"50","author":"Bakunova","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0280","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1021\/jm900805v","volume":"52","author":"Bakunova","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0285","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1016\/j.ejmech.2009.03.014","volume":"44","author":"Patrick","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.10.050_b0290","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrd1416","volume":"3","author":"Fidock","year":"2004","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.bmc.2013.10.050_b0295","doi-asserted-by":"crossref","first-page":"e18045","DOI":"10.1371\/journal.pone.0018045","volume":"6","author":"Arnold","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2013.10.050_b0300","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1475-2875-10-23","volume":"10","author":"Langhorne","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.bmc.2013.10.050_b0305","doi-asserted-by":"crossref","first-page":"e2252","DOI":"10.1371\/journal.pone.0002252","volume":"3","author":"Angulo-Barturen","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2013.10.050_b0310","first-page":"412","author":"Wityak","year":"1996","journal-title":"PCT Int. Appl."},{"key":"10.1016\/j.bmc.2013.10.050_b0315","first-page":"123","author":"Sindkhedkar","year":"2008","journal-title":"PCT Int. Appl."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613009243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613009243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:21:31Z","timestamp":1760833291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089613009243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0968089613009243"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.10.050","relation":{},"ISSN":["0968-0896"],"issn-type":[{"type":"print","value":"0968-0896"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.10.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}