{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:42:14Z","timestamp":1760834534304,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Institute of Allergy and Infectious Disease of the National Institutes of Health","award":["R43 AI066476"],"award-info":[{"award-number":["R43 AI066476"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.bmc.2013.11.009","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T01:30:26Z","timestamp":1384306226000},"page":"419-434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Small molecule inhibitors of anthrax lethal factor toxin"],"prefix":"10.1016","volume":"22","author":[{"given":"John D.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atiyya R.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.","family":"Cardinale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry L.","family":"Bowlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norton P.","family":"Peet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.11.009_b0005","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.micro.55.1.647","volume":"55","author":"Mock","year":"2002","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.bmc.2013.11.009_b0010","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1056\/NEJM199909093411107","volume":"341","author":"Dixon","year":"2002","journal-title":"N. Engl. J. Med."},{"volume":"Vol. 2","year":"1990","author":"Turnbull","key":"10.1016\/j.bmc.2013.11.009_b0015"},{"key":"10.1016\/j.bmc.2013.11.009_b0020","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1001\/jama.287.17.2236","volume":"287","author":"Inglesby","year":"2002","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bmc.2013.11.009_b0025","unstructured":"NIAID, NIAID Biodefense Research Agenda for CDC Category A Agents. 2002, www.niaid.nih.gov\/biodefense\/research\/biotresearchagenda.pdf; pp 8\u201310."},{"key":"10.1016\/j.bmc.2013.11.009_b0030","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3201\/eid0810.020394","volume":"8","author":"Hoffmaster","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.bmc.2013.11.009_b0035","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1128\/AAC.44.6.1766-1766.2000","volume":"44","author":"Choe","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.11.009_b0040","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1128\/AAC.47.7.2362-2365.2003","volume":"47","author":"Price","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.11.009_b0045","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1021\/ci900186w","volume":"49","author":"Chiu","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmc.2013.11.009_b0050","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1021\/ci300121p","volume":"52","author":"Chiu","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmc.2013.11.009_b0055","doi-asserted-by":"crossref","first-page":"e1002638","DOI":"10.1371\/journal.ppat.1002638","volume":"8","author":"Levinsohn","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bmc.2013.11.009_b0060","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.bbrc.2010.07.039","volume":"398","author":"Newman","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmc.2013.11.009_b0065","doi-asserted-by":"crossref","first-page":"e1000906","DOI":"10.1371\/journal.ppat.1000906","volume":"6","author":"Newman","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bmc.2013.11.009_b0070","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1073\/pnas.1018965108","volume":"108","author":"Jennings-Antipov","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.11.009_b0075","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.bmcl.2005.10.088","volume":"16","author":"Xiong","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.11.009_b0080","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1073\/pnas.0502159102","volume":"102","author":"Shoop","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.11.009_b0085","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1021\/cr0206263","volume":"104","author":"Parkin","year":"2004","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2013.11.009_b0090","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1476-8518-2-5","volume":"2","author":"Sawada-Hirai","year":"2004","journal-title":"J. Immune Based Ther. Vaccines"},{"key":"10.1016\/j.bmc.2013.11.009_b0095","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3233\/HAB-2003-12404","volume":"12","author":"Zhao","year":"2003","journal-title":"Hum. Antibodies"},{"key":"10.1016\/j.bmc.2013.11.009_b0100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/n35101999","volume":"414","author":"Bradley","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2013.11.009_b0105","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1073\/pnas.0431098100","volume":"100","author":"Scobie","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.11.009_b0110","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1128\/IAI.72.1.602-605.2004","volume":"72","author":"Sarac","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bmc.2013.11.009_b0115","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1126\/science.109563","volume":"292","author":"Sellman","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bmc.2013.11.009_b0120","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nbt1001-958","volume":"19","author":"Mourez","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bmc.2013.11.009_b0125","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/n35101998","volume":"414","author":"Pannifer","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2013.11.009_b0130","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/418386a","volume":"418","author":"Tonello","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2013.11.009_b0135","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1128\/IAI.66.5.2374-2378.1998","volume":"66","author":"Hammond","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bmc.2013.11.009_b0140","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1073\/pnas.062171599","volume":"99","author":"Cummings","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.11.009_b0145","doi-asserted-by":"crossref","first-page":"40075","DOI":"10.1074\/jbc.M306466200","volume":"278","author":"Tonello","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.11.009_b0150","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nsmb708","volume":"11","author":"Turk","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bmc.2013.11.009_b0155","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1021\/jm050892j","volume":"49","author":"Johnson","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.009_b0160","doi-asserted-by":"crossref","first-page":"9499","DOI":"10.1073\/pnas.0502733102","volume":"102","author":"Forino","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.11.009_b0165","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nsmb711","volume":"11","author":"Panchal","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bmc.2013.11.009_b0170","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bioorg.2006.12.005","volume":"35","author":"Johnson","year":"2007","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bmc.2013.11.009_b0175","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nbt973","volume":"22","author":"Min","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bmc.2013.11.009_b0180","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/jm8013212","volume":"52","author":"Agrawal","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.009_b0185","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/cmdc.200600102","volume":"1","author":"Lewis","year":"2006","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2013.11.009_b0190","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1021\/jm0605132","volume":"49","author":"Schepetkin","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.009_b0195","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1021\/ol050869s","volume":"7","author":"Shultz","year":"2005","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmc.2013.11.009_b0200","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.bmcl.2005.12.038","volume":"16","author":"Jiao","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.11.009_b0205","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1016\/j.bmcl.2006.07.005","volume":"16","author":"Jiao","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.11.009_b0210","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.1021\/ja0495359","volume":"126","author":"Lee","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2013.11.009_b0215","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2210-6-8","volume":"6","author":"Goldman","year":"2006","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.bmc.2013.11.009_b0220","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/sj.embor.7400118","volume":"5","author":"Dell\u2019Aica","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bmc.2013.11.009_b0225","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1080\/00397910802542044","volume":"39","author":"Brouet","year":"2009","journal-title":"Synth. Commun."},{"key":"10.1016\/j.bmc.2013.11.009_b0230","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/BF01886909","volume":"14","author":"Schmidt","year":"1995","journal-title":"J. Protein Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613009401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613009401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:16:36Z","timestamp":1760832996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089613009401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0968089613009401"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.11.009","relation":{},"ISSN":["0968-0896"],"issn-type":[{"type":"print","value":"0968-0896"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small molecule inhibitors of anthrax lethal factor toxin","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}