{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:20:33Z","timestamp":1785154833056,"version":"3.55.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Research Council of Argentina"},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"crossref","award":["200201001003801"],"award-info":[{"award-number":["200201001003801"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.bmc.2013.11.010","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T01:30:24Z","timestamp":1384306224000},"page":"398-405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase"],"prefix":"10.1016","volume":"22","author":[{"given":"Mariana","family":"Ferrer-Casal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Galizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Stortz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio H.","family":"Szajnman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Docampo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia N.J.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan B.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.11.010_b0005","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1517\/13543776.2011.593511","volume":"21","author":"Sun","year":"2011","journal-title":"Expert Opin. Ther. Patents"},{"key":"10.1016\/j.bmc.2013.11.010_b0010","doi-asserted-by":"crossref","first-page":"33930","DOI":"10.1074\/jbc.M103950200","volume":"276","author":"Montalvetti","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0015","doi-asserted-by":"crossref","first-page":"17075","DOI":"10.1074\/jbc.M210467200","volume":"278","author":"Montalvetti","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0020","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1517\/14728222.12.3.253","volume":"12","author":"Moreno","year":"2008","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bmc.2013.11.010_b0025","doi-asserted-by":"crossref","first-page":"30804","DOI":"10.1074\/jbc.M703178200","volume":"282","author":"Ling","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0030","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.1021\/bi3005335","volume":"51","author":"Li","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2013.11.010_b0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0378-1119(93)90326-X","volume":"125","author":"Blanchard","year":"1993","journal-title":"Gene"},{"key":"10.1016\/j.bmc.2013.11.010_b0040","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1073\/pnas.91.8.3044","volume":"91","author":"Song","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.11.010_b0045","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1021\/cr9600464","volume":"98","author":"Ogura","year":"1998","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2013.11.010_b0050","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.pharmtox.38.1.375","volume":"38","author":"Rodan","year":"1998","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bmc.2013.11.010_b0055","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ceca.2011.05.012","volume":"50","author":"Docampo","year":"2011","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bmc.2013.11.010_b0060","doi-asserted-by":"crossref","first-page":"33609","DOI":"10.1074\/jbc.274.47.33609","volume":"274","author":"Urbina","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0065","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1021\/jm0002578","volume":"44","author":"Martin","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0070","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1128\/AAC.46.3.929-931.2002","volume":"46","author":"Yardley","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.11.010_b0075","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1021\/jm0102809","volume":"45","author":"Martin","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0080","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1517\/13543776.2012.668886","volume":"22","author":"Rodriguez","year":"2012","journal-title":"Expert Opin. Ther. Patents"},{"key":"10.1016\/j.bmc.2013.11.010_b0085","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ijantimicag.2003.07.019","volume":"23","author":"Garzoni","year":"2004","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bmc.2013.11.010_b0090","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s00436-005-1331-9","volume":"96","author":"Bouzahzah","year":"2005","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.bmc.2013.11.010_b0095","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1016\/j.bmc.2007.12.010","volume":"16","author":"Szajnman","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0100","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.bmc.2011.02.037","volume":"19","author":"Rosso","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0105","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0960-894X(01)00057-9","volume":"11","author":"Szajnman","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.11.010_b0110","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1016\/S0960-894X(03)00663-2","volume":"13","author":"Szajnman","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.11.010_b0115","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1016\/j.bmcl.2005.07.060","volume":"15","author":"Szajnman","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.11.010_b0120","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1021\/jm040132t","volume":"48","author":"Ling","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0125","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1039\/c1ob06602a","volume":"10","author":"Szajnman","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0130","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1021\/jm970860z","volume":"41","author":"Cinque","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0135","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ejmech.2012.12.015","volume":"60","author":"Recher","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0140","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1128\/AAC.00198-10","volume":"54","author":"Singh","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.11.010_b0145","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1073\/pnas.1118215109","volume":"109","author":"No","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2013.11.010_b0150","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.1021\/jm300425y","volume":"55","author":"Aripirala","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0155","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1021\/bi00510a027","volume":"20","author":"Laskovics","year":"1981","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2013.11.010_b0160","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1016\/S0021-9258(17)34489-7","volume":"253","author":"Poulter","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0165","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/jbmr.5650111016","volume":"11","author":"Van Beek","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bmc.2013.11.010_b0170","first-page":"233","volume":"9","author":"Ebetino","year":"1998","journal-title":"Rev. Contemp. Pharmacother."},{"key":"10.1016\/j.bmc.2013.11.010_b0175","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF02547227","volume":"11","author":"Jung","year":"1973","journal-title":"Calcif. Tissue Res."},{"key":"10.1016\/j.bmc.2013.11.010_b0180","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0277-5387(01)00996-2","volume":"21","author":"Matczak-Jon","year":"2002","journal-title":"Polyhedron"},{"key":"10.1016\/j.bmc.2013.11.010_b0185","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0162-0134(01)00412-3","volume":"89","author":"Gumienna-Kontecka","year":"2002","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bmc.2013.11.010_b0190","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0020-1693(02)00918-0","volume":"339","author":"Gumienna-Kontecka","year":"2002","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.bmc.2013.11.010_b0195","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1021\/jm0702884","volume":"50","author":"Marma","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0200","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1021\/jo00335a053","volume":"46","author":"McKenna","year":"1981","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0205","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-1139(01)00478-X","volume":"112","author":"Berkowitz","year":"2001","journal-title":"J. Fluorine Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0210","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1039\/c39810000930","author":"Blackburn","year":"1981","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmc.2013.11.010_b0215","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1021\/cr051000q","volume":"106","author":"Romanenko","year":"2006","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2013.11.010_b0220","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.2174\/138161210793563635","volume":"16","author":"Roelofs","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2013.11.010_b0225","first-page":"711","volume":"4","author":"Reszka","year":"2004","journal-title":"Mini.-Rev. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0230","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S8756-3282(99)00116-7","volume":"25","author":"Russell","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.bmc.2013.11.010_b0235","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/prot.22614","volume":"78","author":"Huang","year":"2010","journal-title":"Proteins"},{"key":"10.1016\/j.bmc.2013.11.010_b0240","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/prot.22066","volume":"73","author":"Cao","year":"2008","journal-title":"Proteins"},{"key":"10.1016\/j.bmc.2013.11.010_b0245","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/prot.20754","volume":"62","author":"Gabelli","year":"2006","journal-title":"Proteins"},{"key":"10.1016\/j.bmc.2013.11.010_b0250","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1016\/j.ejmech.2009.01.035","volume":"44","author":"Zuliani","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0255","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1016\/00404-0399(50)1382R-","author":"Kruijtzer","year":"1995","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2013.11.010_b0260","doi-asserted-by":"crossref","first-page":"8310","DOI":"10.1021\/jo00130a036","volume":"60","author":"Kieczykowski","year":"1995","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0265","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.jinorgbio.2010.08.004","volume":"104","author":"Demoro","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bmc.2013.11.010_b0270","doi-asserted-by":"crossref","first-page":"164313","DOI":"10.1063\/1.4705371","volume":"136","author":"Pan","year":"2012","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bmc.2013.11.010_b0275","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.chemphys.2007.10.009","volume":"342","author":"Swiatla-Wojcik","year":"2007","journal-title":"Chem. Phys."},{"key":"10.1016\/j.bmc.2013.11.010_b0280","doi-asserted-by":"crossref","first-page":"6602","DOI":"10.1016\/j.tet.2005.04.045","volume":"61","author":"Delain-Bioton","year":"2005","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2013.11.010_b0285","doi-asserted-by":"crossref","first-page":"e740","DOI":"10.1371\/journal.pntd.0000740","volume":"4","author":"Canavaci","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmc.2013.11.010_b0290","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/AAC.47.1.309-316.2003","volume":"43","author":"Gubbels","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2013.11.010_b0295","doi-asserted-by":"crossref","first-page":"33683","DOI":"10.1074\/jbc.M109.044024","volume":"284","author":"Agrawal","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2013.11.010_b0300","unstructured":"gaussian 09, Revision C.01, Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Scalmani, G.; Barone, V.; Mennucci, B.; Petersson, G. A.; Nakatsuji, H.; Caricato, M.; Li, X.; Hratchian, H. P.; Izmaylov, A. F.; Bloino, J.; Zheng, G.; Sonnenberg, J. L.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Vreven, T.; Montgomery, Jr., J. A.; Peralta, J. E.; Ogliaro, F.; Bearpark, M.; Heyd, J. J.; Brothers, E.; Kudin, K. N.; Staroverov, V. N.; Kobayashi, R.; Normand, J.; Raghavachari, K.; Rendell, A.; Burant, J. C.; Iyengar, S. S.; Tomasi, J.; Cossi, M.; Rega, N.; Millam, J. M.; Klene, M.; Knox, J. E.; Cross, J. B.; Bakken, V.; Adamo, C.; Jaramillo, J.; Gomperts, R.; Stratmann, R. E.; Yazyev, O.; Austin, A. J.; Cammi, R.; Pomelli, C.; Ochterski, J. W.; Martin, R. L.; Morokuma, K.; Zakrzewski, V. G.; Voth, G. A.; Salvador, P.; Dannenberg, J. J.; Dapprich, S.; Daniels, A. D.; Farkas, \u00d6.; Foresman, J. B.; Ortiz, J. V.; Cioslowski, J.; Fox, D. J. gaussian Inc., Wallingford CT, 2009."},{"key":"10.1016\/j.bmc.2013.11.010_h0305","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","volume":"37","author":"Lee","year":"1988","journal-title":"Phys. Rev. B."},{"key":"10.1016\/j.bmc.2013.11.010_h0310","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","volume":"98","author":"Becke","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.bmc.2013.11.010_b0310","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1021\/cr9904009","volume":"105","author":"Tomasi","year":"2005","journal-title":"Chem. Rev."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613009413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613009413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:20:33Z","timestamp":1760833233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089613009413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0968089613009413"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.11.010","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}