{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:58:00Z","timestamp":1791903480767,"version":"4.3.4"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.bmc.2013.12.050","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T05:45:18Z","timestamp":1388727918000},"page":"967-977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-\u03b2-hydroxysteroid dehydrogenase (AKR1C3)"],"prefix":"10.1016","volume":"22","author":[{"given":"Jack U.","family":"Flanagan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham J.","family":"Atwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darby G.","family":"Brooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shevan","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent J.M.","family":"Rigoreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Trivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Turnbull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Raynham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.F.","family":"Jamieson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Denny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2013.12.050_b0005","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1042\/bj3510067","volume":"351","author":"Penning","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2013.12.050_b0010","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1158\/0008-5472.CAN-03-2847","volume":"64","author":"Lovering","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmc.2013.12.050_b0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00001813-200202000-00003","volume":"13","author":"Xu","year":"2002","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.bmc.2013.12.050_b0020","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cbi.2008.10.024","volume":"178","author":"Byrns","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bmc.2013.12.050_b0025","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.bmcl.2011.01.010","volume":"21","author":"Adeniji","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2013.12.050_b0030","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1021\/jm201547v","volume":"55","author":"Adeniji","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.12.050_b0035","doi-asserted-by":"crossref","unstructured":"Flanagan, J. U., Yossatmadja, Y., Teague, R. M., Chai, M. Z. L., Turnbull, A. P., Squire, C. J., PLoS One. 7, 2012, e43965. http:\/\/dx.doi.org\/10.1371\/journal.pone.0043965","DOI":"10.1371\/journal.pone.0043965"},{"key":"10.1016\/j.bmc.2013.12.050_b0040","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1021\/js9900093","volume":"88","author":"Ogihara","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bmc.2013.12.050_b0045","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.ejmech.2013.01.047","volume":"62","author":"Heinrich","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.12.050_b0050","doi-asserted-by":"crossref","first-page":"7746","DOI":"10.1021\/jm3007867","volume":"55","author":"Jamieson","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.12.050_b0055","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1021\/jm00052a013","volume":"37","author":"Angelastro","year":"1994","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.12.050_b0060","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1021\/cr050992x","volume":"107","author":"Chinchilla","year":"2007","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2013.12.050_b0065","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.1016\/j.bmc.2008.06.030","volume":"16","author":"Ablordeppey","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2013.12.050_b0070","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1021\/jm00033a008","volume":"37","author":"Lazer","year":"1994","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.12.050_b0075","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1021\/ja039799f","volume":"126","author":"Yee","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2013.12.050_b0080","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jsbmb.2010.11.004","volume":"125","author":"Byrns","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bmc.2013.12.050_b0085","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1158\/0008-5472.CAN-09-3237","volume":"70","author":"Guise","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmc.2013.12.050_b0090","unstructured":"Jamieson, S. M. F.; Gu, Y.; Manesh, D. M.; Guise, C. P.; Foehrenbacher, A.; Pullen, S. M.; Benito, J.; Smaill, J. B.; Patterson, A. V.; Mulaw, M. A.; Konopleva, M.; Bohlander, S. K.; Lock, R. B.; Wilson, W. R. Biochem. Pharmacol. 2013, in press."},{"key":"10.1016\/j.bmc.2013.12.050_b0095","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.1016\/j.tet.2007.04.044","volume":"63","author":"Yang","year":"2007","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2013.12.050_b0100","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/jlcr.1147","volume":"50","author":"Atwell","year":"2007","journal-title":"J. Labelled Compd. Radiopharm."},{"key":"10.1016\/j.bmc.2013.12.050_b0105","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1158\/0008-5472.CAN-08-4023","volume":"69","author":"Singleton","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmc.2013.12.050_b0110","unstructured":"Chen, L.; Lai, W. W.; Nettekoven, M.; Roche, O.; Zheng, D. WO 2008068173 A."},{"key":"10.1016\/j.bmc.2013.12.050_b0115","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1021\/jm970197e","volume":"40","author":"Chatterjee","year":"1997","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2013.12.050_b0120","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1055\/s-1992-21539","author":"Baudin","year":"1992","journal-title":"Synlett"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613010584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089613010584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:21:29Z","timestamp":1760833289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089613010584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0968089613010584"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2013.12.050","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-\u03b2-hydroxysteroid dehydrogenase (AKR1C3)","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2013.12.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}