{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:28:16Z","timestamp":1793194096727,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.bmc.2014.01.029","type":"journal-article","created":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T23:01:07Z","timestamp":1391295667000},"page":"1626-1633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["2-Acylamino-5-nitro-1,3-thiazoles: Preparation and in vitro bioevaluation against four neglected protozoan parasites"],"prefix":"10.1016","volume":"22","author":[{"given":"Carlos","family":"Nava-Zuazo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Ch\u00e1vez-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Moo-Puc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Jes\u00fas","family":"Chan-Bacab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjam\u00edn Otto","family":"Ortega-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermenegilda","family":"Moreno-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"D\u00edaz-Couti\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Hern\u00e1ndez-N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Navarrete-V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2014.01.029_b0005","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrd1824","volume":"4","author":"Pink","year":"2005","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2014.01.029_b0010","unstructured":"Center for Disease Control. http:\/\/www.cdc.gov\/parasites\/npi.html (January 5, 2014)."},{"key":"10.1016\/j.bmc.2014.01.029_b0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.pt.2006.02.015","volume":"22","author":"Savioli","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.bmc.2014.01.029_b0020","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2174\/187152610793180821","volume":"10","author":"Escobedo","year":"2010","journal-title":"Infect. Disord. Drug Targets"},{"key":"10.1016\/j.bmc.2014.01.029_b0025","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.meegid.2009.05.015","volume":"9","author":"Arg\u00fcello-Garc\u00eda","year":"2009","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.bmc.2014.01.029_b0030","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S1368-7646(98)80035-6","volume":"1","author":"Upcroft","year":"1998","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bmc.2014.01.029_b0035","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1128\/CMR.17.4.794-803.2004","volume":"17","author":"Schwebke","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.bmc.2014.01.029_b0040","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/jac\/dkp117","volume":"63","author":"Chan-Bacab","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bmc.2014.01.029_b0045","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1016\/j.bmcl.2011.02.100","volume":"15","author":"Navarrete-V\u00e1zquez","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.01.029_b0050","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1016\/j.bmcl.2010.04.126","volume":"20","author":"Ballard","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.01.029_b0055","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1053\/j.gastro.2008.11.037","volume":"136","author":"Rossignol","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bmc.2014.01.029_b0060","doi-asserted-by":"crossref","first-page":"29798","DOI":"10.1074\/jbc.M109.029470","volume":"284","author":"Rossignol","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2014.01.029_b0065","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1016\/j.bmc.2010.07.008","volume":"18","author":"Nava-Zuazo","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.029_b0070","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1016\/j.ejmech.2009.01.005","volume":"44","author":"Hern\u00e1ndez-N\u00fa\u00f1ez","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.029_b0075","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jmgm.2013.07.008","volume":"45","author":"Aguayo-Ortiz","year":"2013","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.bmc.2014.01.029_b0080","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.1016\/j.bmcl.2013.10.011","volume":"23","author":"Soria-Arteche","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.01.029_b0085","unstructured":"Cuckler, C. A. U.S. 2998480, 1961."},{"key":"10.1016\/j.bmc.2014.01.029_b0090","unstructured":"Kupferberg, B. A.; Mende C. W.; Millman, N.; Singher O. H. U.S. 2735798, 1956."},{"key":"10.1016\/j.bmc.2014.01.029_b0095","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/cbdd.12102","volume":"81","author":"Hidalgo-Figueroa","year":"2013","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bmc.2014.01.029_b0100","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1124\/dmd.108.025494","volume":"37","author":"Xu","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bmc.2014.01.029_b0105","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2174\/138620711795508322","volume":"14","author":"Taboureau","year":"2011","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.bmc.2014.01.029_b0110","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1016\/j.bmcl.2013.03.122","volume":"23","author":"Navarrete-V\u00e1zquez","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.01.029_b0115","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1517\/17460441.2.4.469","volume":"2","author":"Abad-Zapatero","year":"2007","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.bmc.2014.01.029_b0120","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S1359-6446(05)03386-6","volume":"10","author":"Abad-Zapatero","year":"2005","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.bmc.2014.01.029_b0125","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/tx200211v","volume":"24","author":"Meanwell","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bmc.2014.01.029_b0130","doi-asserted-by":"crossref","first-page":"5992","DOI":"10.1016\/j.bmcl.2013.08.030","volume":"23","author":"Shultz","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.01.029_b0135","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1021\/jm201388p","volume":"55","author":"Tarcsay","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.029_b0140","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd2796","volume":"8","author":"Keser\u00fc","year":"2009","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2014.01.029_b0145","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.2174\/156802611796575894","volume":"11","author":"Wilkinson","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.029_b0150","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/AAC.05135-11","volume":"56","author":"Hall","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2014.01.029_b0155","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1093\/jac\/dkt106","volume":"68","author":"M\u00fcller","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bmc.2014.01.029_b0160","first-page":"541","volume":"1","author":"Encarnacion-Dimayuga","year":"2006","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.bmc.2014.01.029_b0165","doi-asserted-by":"crossref","first-page":"345","DOI":"10.7773\/cm.v35i4.1617","volume":"35","author":"Moo-Puc","year":"2009","journal-title":"Cienc. Mar."},{"key":"10.1016\/j.bmc.2014.01.029_b0170","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","volume":"82","author":"Skehan","year":"1990","journal-title":"J. Natl Cancer Inst."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614000571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614000571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:18:22Z","timestamp":1760833102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089614000571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0968089614000571"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2014.01.029","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"2-Acylamino-5-nitro-1,3-thiazoles: Preparation and in vitro bioevaluation against four neglected protozoan parasites","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2014.01.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}