{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:13:22Z","timestamp":1782990802025,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.bmc.2014.01.031","type":"journal-article","created":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T02:00:20Z","timestamp":1391220020000},"page":"1586-1595","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Carbonic anhydrase inhibitors: Synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties"],"prefix":"10.1016","volume":"22","author":[{"given":"Kalyan K.","family":"Sethi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh M.","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammet","family":"Tan\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaultier","family":"Purper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetan","family":"Calafato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Carta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2014.01.031_b0005","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2014.01.031_h0010","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2014.01.031_h0015","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.4155\/fmc.11.69","volume":"3","author":"Supuran","year":"2011","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0020","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1126\/science.1233692","volume":"340","author":"Rummer","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.bmc.2014.01.031_b0015","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1517\/13543776.2013.782394","volume":"23","author":"Aggarwal","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2014.01.031_b0020","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1021\/jm021124k","volume":"46","author":"Winum","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_b0025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bmcl.2003.09.064","volume":"14","author":"Abbate","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.01.031_b0030","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2174\/138161208783877848","volume":"14","author":"Winum","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2014.01.031_b0035","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/med.20068","volume":"26","author":"Winum","year":"2006","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2014.01.031_h0050","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2174\/138161208783877947","volume":"14","author":"Supuran","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2014.01.031_h0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(02)00438-6","volume":"248","author":"Kaur","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bmc.2014.01.031_b0045","series-title":"Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications","first-page":"139","author":"Mincione","year":"2009"},{"key":"10.1016\/j.bmc.2014.01.031_b0050","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2174\/156802607780636726","volume":"7","author":"Thiry","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_b0055","doi-asserted-by":"crossref","first-page":"655","DOI":"10.2174\/138161208783877820","volume":"14","author":"De Simone","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2014.01.031_b0060","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.radonc.2009.06.019","volume":"92","author":"Dubois","year":"2009","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.bmc.2014.01.031_b0065","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1016\/j.bmcl.2009.06.022","volume":"19","author":"Ahlskog","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.01.031_b0070","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1021\/cb1003477","volume":"6","author":"Buller","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bmc.2014.01.031_b0075","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","volume":"27","author":"Supuran","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0095","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2014.01.031_h0100","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.2174\/092986710790979999","volume":"17","author":"Guler","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0105","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bbapap.2009.07.027","volume":"1804","author":"De Simone","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bmc.2014.01.031_h0110","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00262-011-0980-z","volume":"60","author":"Battke","year":"2011","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bmc.2014.01.031_h0115","first-page":"45","volume":"4","author":"Basnyat","year":"2003","journal-title":"Med. Biol."},{"key":"10.1016\/j.bmc.2014.01.031_h0120","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJM200107123450206","volume":"345","author":"Hackett","year":"2001","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmc.2014.01.031_b0090","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nm1534","volume":"13","author":"Gao","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.bmc.2014.01.031_b0095","doi-asserted-by":"crossref","first-page":"8514","DOI":"10.1073\/pnas.0702899104","volume":"104","author":"Ogilvie","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2014.01.031_h0135","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1006\/jmbi.1994.1655","volume":"243","author":"Chakravarty","year":"1994","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2014.01.031_h0140","doi-asserted-by":"crossref","unstructured":"Honndorf, V.S.; Heine, A.; Klebe, G.; Supuran, C.T. http:\/\/dx.doi.org\/10.2210\/pdb1zfq\/pdb.","DOI":"10.2210\/pdb1zfq\/pdb"},{"key":"10.1016\/j.bmc.2014.01.031_h0145","doi-asserted-by":"crossref","first-page":"16233","DOI":"10.1073\/pnas.0908301106","volume":"106","author":"Alterio","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2014.01.031_h0150","doi-asserted-by":"crossref","first-page":"9545","DOI":"10.1073\/pnas.161301298","volume":"98","author":"Whittington","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2014.01.031_b0105","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1021\/jm9900523","volume":"42","author":"Scozzafava","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0160","first-page":"337","volume":"17","author":"Scozzafava","year":"2001","journal-title":"Drug Des. Disc."},{"key":"10.1016\/j.bmc.2014.01.031_h0165","doi-asserted-by":"crossref","first-page":"5168","DOI":"10.1016\/j.bmc.2013.06.035","volume":"21","author":"Sethi","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0170","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.1016\/j.bmc.2013.07.044","volume":"21","author":"Sethi","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0175","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1021\/jm101541x","volume":"54","author":"Pacchiano","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0180","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3109\/14756366.2011.650168","volume":"28","author":"Maresca","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0185","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3109\/14756366.2011.645539","volume":"28","author":"Maresca","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0190","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3109\/14756366.2011.638921","volume":"27","author":"Liu","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0195","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3109\/14756366.2011.621122","volume":"27","author":"Ekinci","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0200","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1016\/j.bmcl.2013.02.092","volume":"23","author":"Vullo","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.01.031_h0205","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.bmcl.2013.01.084","volume":"23","author":"Vullo","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.01.031_h0210","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.bmcl.2013.01.087","volume":"23","author":"Monti","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.01.031_b0130","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fphar.2011.00034","volume":"2","author":"Supuran","year":"2011","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.bmc.2014.01.031_h0220","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1016\/j.bmcl.2010.03.104","volume":"20","author":"Sethi","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.01.031_h0225","author":"Sethi","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_b0140","series-title":"Polypharmacology in Drug Discovery","first-page":"457","article-title":"Carbonic Anhydrases: Off-Targets, Add-on Activities, or Emerging Novel Targets?","author":"Supuran","year":"2012"},{"key":"10.1016\/j.bmc.2014.01.031_b0145","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1016\/j.bmc.2009.04.042","volume":"17","author":"Santos","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0240","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2014.01.031_h0245","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1021\/bi00855a005","volume":"6","author":"Pocker","year":"1967","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2014.01.031_h0250","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1016\/j.bmcl.2010.08.110","volume":"20","author":"Innocenti","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614000595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614000595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:19:43Z","timestamp":1760833183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089614000595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0968089614000595"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2014.01.031","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbonic anhydrase inhibitors: Synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2014.01.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}