{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:23:20Z","timestamp":1770355400211,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.bmc.2014.05.057","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T16:21:31Z","timestamp":1401726091000},"page":"4119-4123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Synthesis and structure\u2013activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease"],"prefix":"10.1016","volume":"22","author":[{"given":"Khalid Mohammed","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fazal","family":"Rahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajmal","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Shabeer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shafqat","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wajid","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Taha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momin","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahnaz","family":"Perveen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Iqbal","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2014.05.057_b0005","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1128\/mr.59.3.451-480.1995","volume":"59","author":"Mobley","year":"1995","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.bmc.2014.05.057_b0010","first-page":"93","volume":"23","author":"Bayerd\u00f6rffer","year":"1988","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.bmc.2014.05.057_b0015","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2049::AID-CNCR1>3.0.CO;2-2","volume":"83","author":"Devesa","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.bmc.2014.05.057_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oxfordjournals.epirev.a036288","volume":"8","author":"Howson","year":"1986","journal-title":"Epidemiol. Rev."},{"key":"10.1016\/j.bmc.2014.05.057_b0025","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/S0959-8049(01)00267-2","volume":"37","author":"Parkin","year":"2001","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bmc.2014.05.057_b0030","first-page":"329","volume":"1","author":"L\u00f3pez-Mu\u00f1oz","year":"2005","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.bmc.2014.05.057_b0035","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1128\/mr.53.1.85-108.1989","volume":"53","author":"Mobley","year":"1989","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.bmc.2014.05.057_b0040","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/jccs.201190017","volume":"58","author":"Rauf","year":"2011","journal-title":"J. Chin. Chem. Soc."},{"key":"10.1016\/j.bmc.2014.05.057_b0045","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2298\/JSC090106060D","volume":"75","author":"Dabholkar","year":"2010","journal-title":"J. Serbian Chem. Soc."},{"key":"10.1016\/j.bmc.2014.05.057_b0050","first-page":"88","volume":"52","author":"Kidwai","year":"2005","journal-title":"Acta. Chim. Slov."},{"key":"10.1016\/j.bmc.2014.05.057_b0055","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1743-422X-8-18","volume":"8","author":"Lee","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.bmc.2014.05.057_b0060","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1016\/j.ejmech.2011.04.005","volume":"46","author":"Balas","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.05.057_b0065","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/0006-2952(85)90335-1","article-title":"Narayanan","volume":"34","author":"Brewer","year":"1985","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bmc.2014.05.057_b0070","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1016\/j.bmcl.2009.06.018","volume":"19","author":"Yan","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.05.057_b0075","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1016\/j.bmcl.2011.05.055","volume":"21","author":"Vijaya Laxmi","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.05.057_b0080","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.bmcl.2009.11.082","volume":"20","author":"Thirupathi Reddy","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.05.057_b0085","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.bmcl.2012.12.053","volume":"23","author":"Narsimha Reddy Penthala","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.05.057_b0090","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/j.bmc.2010.02.001","volume":"18","author":"Chenguang","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2014.05.057_b0095","first-page":"26","volume":"61","author":"Orhan","year":"2006","journal-title":"J. Biosci."},{"key":"10.1016\/j.bmc.2014.05.057_b0100","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.bmcl.2013.12.013","article-title":"Crooks","volume":"24","author":"Madadi","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.05.057_h0105","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jmgm.2011.07.001","volume":"30","author":"Khan","year":"2011","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.bmc.2014.05.057_h0110","first-page":"890","volume":"35","author":"Khan","year":"2013","journal-title":"J. Chem. Soc. Pak."},{"key":"10.1016\/j.bmc.2014.05.057_h0115","first-page":"495","volume":"35","author":"Khan","year":"2013","journal-title":"J. Chem. Soc. Pak."},{"key":"10.1016\/j.bmc.2014.05.057_h0120","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2174\/157340611795564231","volume":"7","author":"Khan","year":"2011","journal-title":"Med. Chem."},{"key":"10.1016\/j.bmc.2014.05.057_h0125","doi-asserted-by":"crossref","first-page":"286","DOI":"10.2174\/157018008784619889","volume":"5","author":"Khan","year":"2008","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.bmc.2014.05.057_h0130","doi-asserted-by":"crossref","first-page":"28","DOI":"10.2174\/157017811794557778","volume":"8","author":"Khan","year":"2011","journal-title":"Lett. Org. Chem."},{"key":"10.1016\/j.bmc.2014.05.057_h0135","first-page":"823","volume":"31","author":"Khan","year":"2009","journal-title":"J. Chem. Soc. Pak."},{"key":"10.1016\/j.bmc.2014.05.057_b0110","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1021\/ac60252a045","volume":"39","author":"Weatherburn","year":"1967","journal-title":"Anal. Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614004167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614004167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:28:08Z","timestamp":1760833688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089614004167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":28,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0968089614004167"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2014.05.057","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and structure\u2013activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2014.05.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}