{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T22:37:47Z","timestamp":1774996667005,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"crossref","award":["503\/1-156-02\/503-01"],"award-info":[{"award-number":["503\/1-156-02\/503-01"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.bmc.2014.06.056","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T00:50:19Z","timestamp":1404867019000},"page":"4803-4809","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2"],"prefix":"10.1016","volume":"22","author":[{"given":"Renata","family":"Perlikowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Piekielna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzena","family":"Mazur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Koralewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Olczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"do Rego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Fichna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Modranka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Janecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Janecka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2014.06.056_b0005","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/386499a0","volume":"386","author":"Zadina","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2014.06.056_b0010","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.ejmech.2004.10.015","volume":"40","author":"Leitgeb","year":"2005","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.06.056_b0015","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1016\/j.bmcl.2009.06.008","volume":"19","author":"Torino","year":"2009","journal-title":"Bioorg. Med. Chem. Let."},{"key":"10.1016\/j.bmc.2014.06.056_b0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2174\/092986608783744199","volume":"15","author":"Gao","year":"2008","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.bmc.2014.06.056_b0025","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/med.20222","volume":"32","author":"Liu","year":"2012","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2014.06.056_b0030","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0006-3495(00)76619-7","volume":"78","author":"Paterlini","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.bmc.2014.06.056_b0035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/bbrc.2000.3416","volume":"276","author":"Okada","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmc.2014.06.056_b0040","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1016\/S0960-894X(00)00562-X","volume":"10","author":"Cardillo","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.06.056_b0045","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1021\/jm011059z","volume":"45","author":"Cardillo","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.06.056_b0050","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1747-0285.2008.00678.x","volume":"72","author":"Staniszewska","year":"2008","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bmc.2014.06.056_b0055","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1016\/j.bmc.2009.04.046","volume":"17","author":"Perlikowska","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2014.06.056_b0060","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.1016\/j.ejmech.2010.07.022","volume":"45","author":"Giordano","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.06.056_b0065","doi-asserted-by":"crossref","first-page":"8418","DOI":"10.1021\/jm300836n","volume":"55","author":"Borics","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.06.056_b0070","first-page":"261","volume":"28","author":"Drevets","year":"1992","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.bmc.2014.06.056_b0075","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1523\/JNEUROSCI.12-09-03628.1992","volume":"12","author":"Drevets","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bmc.2014.06.056_b0080","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.med.49.1.341","volume":"49","author":"Drevets","year":"1998","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bmc.2014.06.056_b0085","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0006-3223(00)00994-X","volume":"48","author":"Sheline","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bmc.2014.06.056_b0090","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/1098-2396(20010301)39:3<239::AID-SYN1005>3.0.CO;2-B","volume":"39","author":"Chen","year":"2001","journal-title":"Synapse"},{"key":"10.1016\/j.bmc.2014.06.056_b0095","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1124\/jpet.102.037861","volume":"303","author":"Tao","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2014.06.056_b0100","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1254\/jphs.93.299","volume":"93","author":"Hung","year":"2003","journal-title":"Pharmacol. Sci."},{"key":"10.1016\/j.bmc.2014.06.056_b0105","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0014-2999(02)01760-0","volume":"446","author":"Ukai","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2014.06.056_b0110","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0306-4522(03)00241-0","volume":"120","author":"Bujdos\u00f3","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.bmc.2014.06.056_b0115","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.peptides.2004.02.009","volume":"25","author":"Huang","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.bmc.2014.06.056_b0120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0167-0115(02)00257-4","volume":"111","author":"Al-Khrasani","year":"2003","journal-title":"Regul. Pept."},{"key":"10.1016\/j.bmc.2014.06.056_b0125","first-page":"327","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.bmc.2014.06.056_b0130","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0278-5846(87)90002-9","volume":"11","author":"Steru","year":"1987","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bmc.2014.06.056_b0135","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.2174\/138161209788168100","volume":"15","author":"Berrocoso","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2014.06.056_b0140","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ejphar.2012.11.003","volume":"698","author":"Filho","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2014.06.056_b0145","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1124\/jpet.109.159939","volume":"332","author":"Onali","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2014.06.056_b0150","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/0278-5846(94)90132-5","volume":"18","author":"Valverde","year":"1994","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bmc.2014.06.056_b0155","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/15622970601003973","volume":"7","author":"Baghai","year":"2006","journal-title":"World J. Biochem. Psychiatry"},{"key":"10.1016\/j.bmc.2014.06.056_b0160","doi-asserted-by":"crossref","first-page":"9906","DOI":"10.1021\/ja047281l","volume":"126","author":"Li","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2014.06.056_b0165","first-page":"645","volume":"79","author":"Berestovitskaya","year":"2009","journal-title":"Russ. J. Gen. Chem."},{"key":"10.1016\/j.bmc.2014.06.056_b0170","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.peptides.2007.12.005","volume":"29","author":"Fichna","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.bmc.2014.06.056_b0175","doi-asserted-by":"crossref","first-page":"6977","DOI":"10.1016\/j.bmc.2011.10.040","volume":"19","author":"Fichna","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2014.06.056_b0180","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/sj.npp.1301149","volume":"32","author":"Fichna","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bmc.2014.06.056_b0185","series-title":"Encyclopedia of psychopharmacology","first-page":"202","author":"Lucki","year":"2010"},{"key":"10.1016\/j.bmc.2014.06.056_b0190","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/S0196-9781(02)00100-6","volume":"23","author":"Tomboly","year":"2002","journal-title":"Peptides"},{"key":"10.1016\/j.bmc.2014.06.056_b0195","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0006-2952(03)00391-5","volume":"66","author":"Sakurada","year":"2003","journal-title":"Biochem Pharmacol."},{"key":"10.1016\/j.bmc.2014.06.056_b0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(98)00423-3","volume":"354","author":"Tejedor-Real","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2014.06.056_b0205","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1208\/s12248-009-9105-4","volume":"11","author":"Aldrich","year":"2009","journal-title":"AAPS J."},{"key":"10.1016\/j.bmc.2014.06.056_b0210","first-page":"18","article-title":"Contin. Educ. Anaesth. Crit. Care","volume":"5","author":"Ryder","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.bmc.2014.06.056_b0215","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0024-3205(92)90501-F","volume":"51","author":"Misicka","year":"1992","journal-title":"Life Sci."},{"key":"10.1016\/j.bmc.2014.06.056_b0220","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.peptides.2009.12.002","volume":"31","author":"Perlikowska","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.bmc.2014.06.056_b0225","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.neuropharm.2011.07.021","volume":"61","author":"Cravezic","year":"2011","journal-title":"Neuropharmacology"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614005021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614005021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:26:24Z","timestamp":1760833584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089614005021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":45,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0968089614005021"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2014.06.056","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2014.06.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}