{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:58:56Z","timestamp":1778821136895,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004507","name":"CDRI","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004507","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.bmc.2014.09.009","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T03:37:55Z","timestamp":1410838675000},"page":"5950-5960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Synthesis of chiral chloroquine and its analogues as antimalarial agents"],"prefix":"10.1016","volume":"22","author":[{"given":"Manish","family":"Sinha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasanth R.","family":"Dola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awakash","family":"Soni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumkum","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wahajul","family":"Haq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil K.","family":"Puri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seturam B.","family":"Katti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2014.09.009_b0005","unstructured":"http:\/\/www.who.int\/malaria\/media\/world_malaria_report_2013\/en\/."},{"key":"10.1016\/j.bmc.2014.09.009_h0010","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1016\/j.ejmech.2010.04.011","volume":"45","author":"Kaur","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.09.009_h0015","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4103\/0975-7406.67002","volume":"2","author":"Bawa","year":"2010","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.bmc.2014.09.009_h0020","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/j.1552-4604.1994.tb01986.x","volume":"34","author":"Brocks","year":"1994","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.bmc.2014.09.009_h0025","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1365-2125.1986.tb02900.x","volume":"22","author":"Ofori-Adjei","year":"1986","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.bmc.2014.09.009_h0030","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/00007691-198612000-00014","volume":"8","author":"Ofori-Adjei","year":"1986","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.bmc.2014.09.009_h0035","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/BF00315548","volume":"44","author":"McLachlan","year":"1993","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.bmc.2014.09.009_b0020","first-page":"163","volume":"29","author":"Fink","year":"1979","journal-title":"Arzneim. Forsch."},{"key":"10.1016\/j.bmc.2014.09.009_b0025","first-page":"308","volume":"30","author":"Haberkorn","year":"1979","journal-title":"Tropenmed. Parasitol."},{"key":"10.1016\/j.bmc.2014.09.009_b0030","first-page":"93","volume":"22","author":"Fu","year":"1986","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.bmc.2014.09.009_b0035","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1021\/jo00241a009","volume":"53","author":"Craig","year":"1988","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2014.09.009_b0040","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/(SICI)1520-636X(1998)10:7<556::AID-CHIR2>3.0.CO;2-0","volume":"10","author":"Blauer","year":"1998","journal-title":"Chirality"},{"key":"10.1016\/j.bmc.2014.09.009_b0045","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1021\/jo062653p","volume":"72","author":"Cruz","year":"2007","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2014.09.009_b0050","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1021\/jm061078e","volume":"50","author":"Corbo","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.09.009_b0055","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1039\/B303249N","volume":"1","author":"Vescovi","year":"2003","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bmc.2014.09.009_b0060","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/jm900946n","volume":"53","author":"Breuning","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.09.009_b0065","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1021\/ol061133d","volume":"8","author":"Metro","year":"2006","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmc.2014.09.009_b0070","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1021\/ja01151a554","volume":"73","author":"Vaughan","year":"1951","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2014.09.009_b0075","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1021\/ie50472a002","volume":"41","author":"Kenyon","year":"1949","journal-title":"Ind. Eng. Chem."},{"key":"10.1016\/j.bmc.2014.09.009_b0080","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1016\/j.ejmech.2010.07.068","volume":"45","author":"Solomon","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.09.009_b0085","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.exppara.2010.08.007","volume":"127","author":"Singh","year":"2011","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bmc.2014.09.009_b0090","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.bmc.2014.05.024","volume":"22","author":"Sinha","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2014.09.009_b0095","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/expr.1999.4465","volume":"94","author":"Puri","year":"2000","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bmc.2014.09.009_b0100","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0162-0134(97)00086-X","volume":"68","author":"Egan","year":"1997","journal-title":"Inorg. Biochem."},{"key":"10.1016\/j.bmc.2014.09.009_b0105","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ab.2003.10.016","volume":"325","author":"Tripathi","year":"2004","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bmc.2014.09.009_b0110","unstructured":"GraphPad Prism, Version 3.0, GraphPad Software, 10855 Sorrento Valley Rd. #203, San Diego, CA 92121, 1999."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614006452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614006452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:25:44Z","timestamp":1760833544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089614006452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":26,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0968089614006452"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2014.09.009","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of chiral chloroquine and its analogues as antimalarial agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2014.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}