{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:12:34Z","timestamp":1790957554412,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.bmc.2014.09.017","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T06:57:26Z","timestamp":1410850646000},"page":"5910-5916","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Human \u03b11-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines"],"prefix":"10.1016","volume":"22","author":[{"given":"Junli","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian P.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaniz F.","family":"Urmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence P.G.","family":"Wakelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Denny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Finch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2014.09.017_b0005","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1476-5381.1996.tb15742.x","volume":"119","author":"Nasu","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bmc.2014.09.017_b0010","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4111\/kju.2012.53.3.139","volume":"53","author":"Yoo","year":"2012","journal-title":"Korean J. Urol."},{"key":"10.1016\/j.bmc.2014.09.017_b0015","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0090-4295(98)00140-X","volume":"51","author":"Beduschi","year":"1998","journal-title":"Urology"},{"key":"10.1016\/j.bmc.2014.09.017_b0020","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1464-410X.2003.04590.x","volume":"92","author":"Andersson","year":"2003","journal-title":"BJU Int."},{"key":"10.1016\/j.bmc.2014.09.017_b0025","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jcrs.2007.10.045","volume":"34","author":"Palea","year":"2008","journal-title":"J. Cataract Refract. Surg."},{"key":"10.1016\/j.bmc.2014.09.017_b0030","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1161\/01.CIR.100.23.2336","volume":"100","author":"Rudner","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.bmc.2014.09.017_b0035","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0021-5198(19)35067-X","volume":"79","author":"Takei","year":"1999","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.bmc.2014.09.017_b0040","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1464-410X.2005.05485.x","volume":"95","author":"Milani","year":"2005","journal-title":"BJU Int."},{"key":"10.1016\/j.bmc.2014.09.017_b0045","first-page":"S18","volume":"8","author":"Wolters","year":"2006","journal-title":"Rev. Urol."},{"key":"10.1016\/j.bmc.2014.09.017_b0050","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0014-2999(86)90202-5","volume":"127","author":"Adams","year":"1986","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2014.09.017_b0055","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0026-895X(25)12379-1","volume":"27","author":"Adams","year":"1985","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmc.2014.09.017_b0060","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.bcp.2013.03.010","volume":"85","author":"Chen","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bmc.2014.09.017_b0065","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1021\/jm00104a008","volume":"35","author":"Denny","year":"1992","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.09.017_b0070","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/S0968-0896(99)00178-9","volume":"7","author":"Han","year":"1999","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.bmc.2014.09.017_b0075","series-title":"Dissociation Constants of Organic Bases in Aqueous Solution","author":"Perrin","year":"1965"},{"key":"10.1016\/j.bmc.2014.09.017_b0080","doi-asserted-by":"crossref","first-page":"28318","DOI":"10.1074\/jbc.271.45.28318","volume":"271","author":"Porter","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2014.09.017_b0085","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1073\/pnas.84.13.4384","volume":"84","author":"Strader","year":"1987","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2014.09.017_b0090","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0026-895X(25)09540-9","volume":"50","author":"Zhao","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmc.2014.09.017_b0095","doi-asserted-by":"crossref","first-page":"23189","DOI":"10.1074\/jbc.270.39.23189","volume":"270","author":"Hwa","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2014.09.017_b0100","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1126\/science.1197410","volume":"330","author":"Chien","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bmc.2014.09.017_b0105","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","volume":"234","author":"Sali","year":"1993","journal-title":"J. Mol. Biol."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614006634?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614006634?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:25:21Z","timestamp":1760833521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089614006634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":21,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0968089614006634"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2014.09.017","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human \u03b11-adrenoceptor subtype selectivity of substituted homobivalent 4-aminoquinolines","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2014.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}