{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:09:19Z","timestamp":1786406959458,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.bmc.2014.09.033","type":"journal-article","created":{"date-parts":[[2014,9,20]],"date-time":"2014-09-20T12:33:01Z","timestamp":1411216381000},"page":"5790-5803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["AFQ056\/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization"],"prefix":"10.1016","volume":"22","author":[{"given":"Ivo","family":"Vranesic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Ofner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Josef","family":"Flor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Bilbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochdi","family":"Bouhelal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Enz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Desrayaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"McAllister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Gasparini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2014.09.033_b0005","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1161\/01.STR.26.4.602","volume":"26","author":"Grotta","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.bmc.2014.09.033_b0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0920-1211(93)90031-2","volume":"16","author":"Sveinbjornsdottir","year":"1993","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.bmc.2014.09.033_b0015","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1161\/01.STR.31.2.347","volume":"31","author":"Davis","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.bmc.2014.09.033_b0020","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.neuropharm.2010.10.022","volume":"60","author":"Nicoletti","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmc.2014.09.033_b0025","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/S0028-3908(99)00082-9","volume":"38","author":"Gasparini","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmc.2014.09.033_b0030","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0022-3565(24)34881-5","volume":"290","author":"Varney","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2014.09.033_b0035","doi-asserted-by":"crossref","first-page":"33750","DOI":"10.1074\/jbc.M006230200","volume":"275","author":"Pagano","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2014.09.033_b0040","doi-asserted-by":"crossref","first-page":"680","DOI":"10.2174\/1568026611109060680","volume":"11","author":"Rocher","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2014.09.033_b0045","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1021\/jm025570j","volume":"46","author":"Cosford","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.09.033_b0050","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1021\/jm900172f","volume":"52","author":"Kulkarni","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.09.033_b0055","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1016\/j.bmcl.2007.06.030","volume":"17","author":"Milbank","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.09.033_b0060","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.bmcl.2006.12.033","volume":"17","author":"Jaeschke","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.09.033_b0065","first-page":"655","volume":"11","author":"Gasparini","year":"2008","journal-title":"Curr. Opin. Drug Discov. Devel."},{"key":"10.1016\/j.bmc.2014.09.033_b0070","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/mds.23616","volume":"26","author":"Berg","year":"2011","journal-title":"Mov. Disord."},{"key":"10.1016\/j.bmc.2014.09.033_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.3001708","volume":"3","author":"Jacquemont","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bmc.2014.09.033_b0090","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/0028-3908(95)00085-K","volume":"34","author":"Daggett","year":"1995","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmc.2014.09.033_b0095","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1021\/jm901811v","volume":"53","author":"Widler","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2014.09.033_b0100","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0026-895X(24)12169-4","volume":"55","author":"Litschig","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmc.2014.09.033_b0105","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0960-894X(01)00767-3","volume":"12","author":"Gasparini","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2014.09.033_b0110","first-page":"514","volume":"31","author":"Tanswell","year":"1993","journal-title":"J. Clin. Pharmacol. Ther. Toxicol."},{"key":"10.1016\/j.bmc.2014.09.033_b0115","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1124\/dmd.112.050716","volume":"41","author":"Walles","year":"2013","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bmc.2014.09.033_b0120","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0022-3565(24)39029-9","volume":"295","author":"Spooren","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2014.09.033_b0125","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0028-3908(02)00082-5","volume":"43","author":"Pilc","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmc.2014.09.033_b0130","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1046\/j.1460-9568.2002.02294.x","volume":"16","author":"Brodkin","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bmc.2014.09.033_b0135","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0014-2999(01)01562-X","volume":"435","author":"Spooren","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2014.09.033_b0140","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1124\/jpet.111.185660","volume":"339","author":"Lindemann","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2014.09.033_b0145","unstructured":"Allgeier, H.; Auberson, Y.; Biollaz, M.; Cosford, N. D.; Gasparini, F.; Heckendorn, R.; Johnson, E. C.; Kuhn, R.; Varney, M. A.; Velicelebi, G. From PCT Int. Appl. WO 9,902,497 A2 19,990,121; Chem. Abstr. 1999, 130, 153580."},{"key":"10.1016\/j.bmc.2014.09.033_b0150","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature13396","volume":"511","author":"Dor\u00e9","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2014.09.033_b0155","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/S0040-4039(00)90152-7","volume":"25","author":"Dolfini","year":"1965","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2014.09.033_b0160","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1460-9568.1995.tb00666.x","volume":"7","author":"Flor","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bmc.2014.09.033_b0165","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0028-3908(94)00149-M","volume":"34","author":"Flor","year":"1995","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmc.2014.09.033_b0170","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/S0028-3908(96)00176-1","volume":"36","author":"Flor","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmc.2014.09.033_b0175","doi-asserted-by":"crossref","first-page":"640","DOI":"10.2533\/000942904777677533","volume":"58","author":"Mickel","year":"2004","journal-title":"Chimia"},{"key":"10.1016\/j.bmc.2014.09.033_b0180","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0031-9384(97)00157-1","volume":"62","author":"Van der Heyden","year":"1997","journal-title":"Physiol. Behav."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614006798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089614006798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:30:33Z","timestamp":1760833833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089614006798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":34,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0968089614006798"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2014.09.033","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AFQ056\/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2014.09.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}