{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:03:34Z","timestamp":1760918614738,"version":"build-2065373602"},"reference-count":50,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"South African National Research Foundation","award":["FA2007050300003"],"award-info":[{"award-number":["FA2007050300003"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.bmc.2015.01.036","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T12:38:12Z","timestamp":1422448692000},"page":"5131-5143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites"],"prefix":"10.1016","volume":"23","author":[{"given":"Bianca K.","family":"Verlinden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marna","family":"de Beer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boobalan","family":"Pachaiyappan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan","family":"Besaans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren A.","family":"Andayi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janette","family":"Reader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jandeli","family":"Niemand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riette","family":"van Biljon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiplin","family":"Guy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Egan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick M.","family":"Woster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5888-2905","authenticated-orcid":false,"given":"Lyn-Marie","family":"Birkholtz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2015.01.036_b0005","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1126\/science.1211936","volume":"334","author":"Meister","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bmc.2015.01.036_b0010","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1126\/science.1193225","volume":"329","author":"Rottmann","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bmc.2015.01.036_b0015","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1073\/pnas.1015762108","volume":"108","author":"Charman","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.01.036_b0020","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.1021\/jm200592f","volume":"54","author":"Coteron","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0025","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1021\/jm3001373","volume":"55","author":"Younis","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0030","first-page":"1","volume":"15","author":"Wallace","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2015.01.036_b0035","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1042\/bst0310393","volume":"31","author":"Wallace","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bmc.2015.01.036_b0040","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0960-894X(01)00315-8","volume":"11","author":"Zou","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.01.036_b0045","first-page":"993","volume":"13","author":"Seiler","year":"1998","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bmc.2015.01.036_b0050","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1042\/bj20020156","volume":"367","author":"Fraser","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2015.01.036_b0055","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrd2243","volume":"6","author":"Casero","year":"2007","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2015.01.036_b0060","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1073\/pnas.86.2.651","volume":"86","author":"Bitonti","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.01.036_b0065","first-page":"203","volume":"5","author":"Woster","year":"2003","journal-title":"Ann. Rep. Med. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0070","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1128\/AAC.34.5.722","volume":"34","author":"Hanson","year":"1990","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2015.01.036_b0075","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1016\/S0960-894X(96)00510-0","volume":"6","author":"Baohbedaso","year":"1996","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.01.036_b0080","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1073\/pnas.86.2.651","volume":"86","author":"Dumont","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.01.036_b0085","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1042\/BJ20110362","volume":"438","author":"William","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2015.01.036_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/jm200463z","volume":"54","author":"Verlinden","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0095","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.1021\/jm100217a","volume":"53","author":"Sharma","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0100","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1021\/jm058208o","volume":"48","author":"Dominguez","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0105","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1021\/jm300887b","volume":"56","author":"Mei","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0110","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1021\/jm031132g","volume":"47","author":"Egan","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0115","first-page":"285","volume":"13","author":"Carter","year":"2010","journal-title":"Comb. Chem. HTS"},{"key":"10.1016\/j.bmc.2015.01.036_b0120","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.bmcl.2012.11.072","volume":"23","author":"Liew","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.01.036_b0125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejmech.2013.07.055","volume":"69","author":"Liew","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0130","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1475-2875-12-187","volume":"12","author":"Burrows","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.bmc.2015.01.036_b0135","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1042\/bj2420221","volume":"242","author":"Assaraf","year":"1987","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2015.01.036_b0140","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/1475-2875-12-424","volume":"12","author":"Le Manach","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.bmc.2015.01.036_b0145","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.pt.2014.07.004","volume":"30","author":"Leroy","year":"2014","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.bmc.2015.01.036_b0150","doi-asserted-by":"crossref","first-page":"E1214","DOI":"10.1073\/pnas.1112037108","volume":"108","author":"Adjalley","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.01.036_b0155","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1038\/srep03743","volume":"4","author":"Sun","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bmc.2015.01.036_b0160","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1186\/1475-2875-12-408","volume":"12","author":"Duffy","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.bmc.2015.01.036_b0165","series-title":"Polyamine Metabolism in Plasmodia","article-title":"Encyclopedia of Malaria","author":"Birkholtz","year":"2013"},{"key":"10.1016\/j.bmc.2015.01.036_b0170","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1021\/ci8001414","volume":"48","author":"Guha","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmc.2015.01.036_b0175","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1021\/ci7004093","volume":"48","author":"Guha","year":"2008","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmc.2015.01.036_b0180","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1021\/jm00106a015","volume":"34","author":"Edwards","year":"1991","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0185","first-page":"2959","volume":"1","author":"Bergeron","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.bmc.2015.01.036_b0190","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1021\/jm00013a003","volume":"38","author":"Bergeron","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0195","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1021\/jm100293f","volume":"53","author":"Melchoirre","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0200","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1016\/j.bmcl.2006.03.048","volume":"16","author":"Lopez","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.01.036_b0205","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1039\/jr9510002492","volume":"1951","author":"Angyal","year":"1951","journal-title":"J. Chem. Soc."},{"key":"10.1016\/j.bmc.2015.01.036_b0210","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.1021\/jo005521j","volume":"65","author":"Rodima","year":"2000","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2015.01.036_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20031327","volume":"376","author":"Wallace","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2015.01.036_b0220","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1016\/j.bmcl.2006.03.048","volume":"16","author":"Bi","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.01.036_b0225","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.bmc.2015.01.036_b0230","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","volume":"65","author":"Lambros","year":"1979","journal-title":"J. Parasitol."},{"key":"10.1016\/j.bmc.2015.01.036_b0235","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1128\/AAC.48.5.1803-1806.2004","volume":"48","author":"Smilkstein","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2015.01.036_b0240","first-page":"1","author":"Malmquist","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.01.036_b0245","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ab.2004.11.022","volume":"338","author":"Ncokazi","year":"2005","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bmc.2015.01.036_b0250","doi-asserted-by":"crossref","first-page":"6050","DOI":"10.1128\/AAC.00870-13","volume":"57","author":"Lucantoni","year":"2013","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615000528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615000528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:33:44Z","timestamp":1760834024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089615000528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":50,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0968089615000528"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2015.01.036","relation":{},"ISSN":["0968-0896"],"issn-type":[{"type":"print","value":"0968-0896"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2015.01.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}