{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:35:18Z","timestamp":1792895718654,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["SR\/FT\/CS-108\/2010"],"award-info":[{"award-number":["SR\/FT\/CS-108\/2010"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"CSIR","doi-asserted-by":"publisher","award":["37 (1630)\/14\/EMR-II"],"award-info":[{"award-number":["37 (1630)\/14\/EMR-II"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.bmc.2015.02.029","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T14:38:42Z","timestamp":1424788722000},"page":"1817-1827","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Design, synthesis and biological evaluation of functionalized phthalimides: A new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite"],"prefix":"10.1016","volume":"23","author":[{"given":"Anil K.","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinoth","family":"Rajendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akansha","family":"Pant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prahlad C.","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelu","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Latha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash C.","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brajendra K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brijesh","family":"Rathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2015.02.029_b0005","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(12)60034-8","volume":"379","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2015.02.029_b0010","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1126\/science.1205216","volume":"333","author":"Yuan","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bmc.2015.02.029_h0015","author":"Oaks","year":"1991"},{"key":"10.1016\/j.bmc.2015.02.029_h0020","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/expr.1997.4225","volume":"87","author":"Westling","year":"1997","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bmc.2015.02.029_h0025","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1021\/jm980641t","volume":"42","author":"Haque","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.029_b0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0166-6851(01)00427-3","volume":"119","author":"Krugliak","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.bmc.2015.02.029_b0025","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1073\/pnas.1218412110","volume":"110","author":"Chugh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.02.029_b0030","doi-asserted-by":"crossref","first-page":"9138","DOI":"10.1073\/pnas.0502368102","volume":"102","author":"Pandey","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.02.029_b0035","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1073\/pnas.0307720101","volume":"101","author":"Sijwali","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.02.029_b0040","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1098\/rstb.2011.0091","volume":"366","author":"Hill","year":"2011","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.bmc.2015.02.029_b0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.actatropica.2011.03.005","volume":"118","author":"Murambiwa","year":"2011","journal-title":"Acta Trop."},{"key":"10.1016\/j.bmc.2015.02.029_b0050","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4269\/ajtmh.2001.64.12","volume":"64","author":"Trape","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.bmc.2015.02.029_b0055","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1086\/497698","volume":"192","author":"Marks","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bmc.2015.02.029_b0060","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/QCO.0b013e3282f1673a","volume":"20","author":"Egan","year":"2007","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.bmc.2015.02.029_b0065","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1182\/blood.V77.2.306.306","volume":"77","author":"Gottschall","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.bmc.2015.02.029_b0070","first-page":"1221","volume":"25","author":"Veinot","year":"1998","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.bmc.2015.02.029_b0075","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/jhet.5570260226","volume":"26","author":"Badawey","year":"1989","journal-title":"Heterocyc. Chem."},{"key":"10.1016\/j.bmc.2015.02.029_b0080","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","volume":"361","author":"Dondorp","year":"2009","journal-title":"Engl. J. Med."},{"key":"10.1016\/j.bmc.2015.02.029_b0085","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1086\/657120","volume":"51","author":"Noedl","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bmc.2015.02.029_b0090","doi-asserted-by":"crossref","first-page":"e4551","DOI":"10.1371\/journal.pone.0004551","volume":"4","author":"Carrara","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bmc.2015.02.029_b0095","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nchembio.142","volume":"5","author":"Stanton","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bmc.2015.02.029_b0100","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nchembio.479","volume":"6","author":"Dandapani","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bmc.2015.02.029_b0105","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.1002\/anie.200801566","volume":"47","author":"Noren-Muller","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bmc.2015.02.029_b0110","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.exppara.2011.02.025","volume":"128","author":"Mendoza","year":"2011","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bmc.2015.02.029_b0115","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1016\/j.ejmech.2009.03.041","volume":"44","author":"Cunico","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.029_b0120","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1021\/jm200227r","volume":"54","author":"Ndakala","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.029_b0125","series-title":"Vogel\u2019s Textbook of Practical Organic Chemistry","author":"Furniss","year":"1989"},{"key":"10.1016\/j.bmc.2015.02.029_b0130","doi-asserted-by":"crossref","first-page":"14750","DOI":"10.1039\/c3ra41089g","volume":"3","author":"Singh","year":"2013","journal-title":"RSC Adv."},{"key":"10.1016\/j.bmc.2015.02.029_b0135","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/poc.3287","volume":"27","author":"Singh","year":"2014","journal-title":"J. Phys. Org. Chem."},{"key":"10.1016\/j.bmc.2015.02.029_b0140","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.bmc.2015.02.029_b0145","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1128\/AAC.16.6.710","volume":"16","author":"Desjardins","year":"1979","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2015.02.029_b0150","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1128\/AAC.44.9.2442-2451.2000","volume":"44","author":"Krugliak","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2015.02.029_b0155","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0022-2836(77)80200-3","volume":"112","author":"Bowie","year":"1977","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2015.02.029_b0160","doi-asserted-by":"crossref","first-page":"W116","DOI":"10.1093\/nar\/gkl282","volume":"34","author":"Dundas","year":"2006","journal-title":"Nucleic Acid Res."},{"key":"10.1016\/j.bmc.2015.02.029_b0165","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1093\/bioinformatics\/bti315","volume":"21","author":"Laurie","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bmc.2015.02.029_b0170","unstructured":"Maestro, version 9.8; Schr\u00f6dinger, LLC, New York, NY, 2014."},{"key":"10.1016\/j.bmc.2015.02.029_b0175","unstructured":"LigPrep, version 3.0; Schr\u00f6dinger, LLC, New York, NY, 2014."},{"key":"10.1016\/j.bmc.2015.02.029_b0180","unstructured":"QikProp, version 4.0; Schr\u00f6dinger, LLC, New York, NY, 2014."},{"key":"10.1016\/j.bmc.2015.02.029_b0185","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","volume":"47","author":"Friesner","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.029_b0190","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","volume":"49","author":"Friesner","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.029_b0195","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/jcc.21372","volume":"31","author":"Rastelli","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bmc.2015.02.029_b0200","doi-asserted-by":"crossref","first-page":"e93008","DOI":"10.1371\/journal.pone.0093008","volume":"9","author":"Sunderraj","year":"2014","journal-title":"PLoS ONE"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615001236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615001236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:31:28Z","timestamp":1760833888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089615001236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S0968089615001236"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2015.02.029","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and biological evaluation of functionalized phthalimides: A new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2015.02.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}