{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:57:33Z","timestamp":1791644253368,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Science and Technology Partnerships","award":["ICRD008-015"],"award-info":[{"award-number":["ICRD008-015"]}]},{"name":"Department of Biotechnology, Government of India"},{"DOI":"10.13039\/100009663","name":"University Health Network","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007675","name":"International Center for Genetic Engineering and Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007675","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Birla Institute of Technology & Science"},{"name":"Therapure Biopharma Inc."},{"name":"Lifecare Innovations Pvt. Ltd"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.bmc.2015.02.062","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T12:22:05Z","timestamp":1427286125000},"page":"2221-2240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents"],"prefix":"10.1016","volume":"23","author":[{"given":"Sai Kumar","family":"Chakka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Kalamuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srividhya","family":"Sundararaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianhu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourabh","family":"Mundra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakrishnan","family":"Mahesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Mohmmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi P.","family":"Kotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2015.02.062_b0005","unstructured":"World Malaria Report 2012, World Health Organization."},{"key":"10.1016\/j.bmc.2015.02.062_b0010","unstructured":"World Health Organization, December 2012."},{"key":"10.1016\/j.bmc.2015.02.062_b0015","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1172\/JCI21682","volume":"113","author":"White","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bmc.2015.02.062_b0020","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","volume":"361","author":"Dondorp","year":"2009","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmc.2015.02.062_b0025","doi-asserted-by":"crossref","first-page":"e52236","DOI":"10.1371\/journal.pone.0052236","volume":"7","author":"Starzengruber","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2015.02.062_b0030","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1021\/jm7010673","volume":"51","author":"Bello","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0035","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1021\/jm101642g","volume":"54","author":"Lewis","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0040","doi-asserted-by":"crossref","first-page":"9988","DOI":"10.1021\/jm301176r","volume":"55","author":"Purohit","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0045","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1021\/jm301678j","volume":"56","author":"Crandall","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0050","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4155\/fmc.13.198","volume":"6","author":"Mundra","year":"2014","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0055","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4269\/ajtmh.1970.19.202","volume":"19","author":"Van Dyke","year":"1970","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.bmc.2015.02.062_b0060","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1128\/mr.43.4.453-495.1979","volume":"43","author":"Sherman","year":"1979","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.bmc.2015.02.062_b0065","first-page":"275","volume":"295","author":"Goldberg","year":"2005","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.bmc.2015.02.062_b0070","doi-asserted-by":"crossref","first-page":"11503","DOI":"10.1073\/pnas.0600489103","volume":"103","author":"Wang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.02.062_b0075","doi-asserted-by":"crossref","first-page":"25425","DOI":"10.1074\/jbc.M603776200","volume":"281","author":"Hogg","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0080","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1073\/pnas.0307720101","volume":"101","author":"Sijwali","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.02.062_b0085","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1073\/pnas.1218412110","volume":"110","author":"Chugh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.02.062_b0090","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/978-1-4419-8414-2_3","volume":"712","author":"Rosenthal","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bmc.2015.02.062_b0095","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.bbrc.2005.08.213","volume":"336","author":"Dasaradhi","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmc.2015.02.062_b0100","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.str.2011.03.025","volume":"19","author":"Hansen","year":"2011","journal-title":"Structure"},{"key":"10.1016\/j.bmc.2015.02.062_b0105","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/med.20163","volume":"30","author":"Ettari","year":"2010","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2015.02.062_b0110","series-title":"Cysteine Proteases of Pathogenic Organisms","first-page":"30","author":"Rosenthal","year":"2011"},{"key":"10.1016\/j.bmc.2015.02.062_b0115","doi-asserted-by":"crossref","first-page":"408","DOI":"10.2174\/156802612799362913","volume":"12","author":"Marco","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0120","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1073\/pnas.022630099","volume":"99","author":"Banerjee","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.02.062_b0125","doi-asserted-by":"crossref","first-page":"8202","DOI":"10.1021\/jm1009567","volume":"53","author":"Gibbons","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0130","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s12272-012-0902-4","volume":"35","author":"Liu","year":"2012","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.bmc.2015.02.062_b0135","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1517\/13543776.2013.743992","volume":"23","author":"Mane","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2015.02.062_b0140","doi-asserted-by":"crossref","first-page":"e1023","DOI":"10.1371\/journal.pntd.0001023","volume":"5","author":"Ang","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmc.2015.02.062_b0145","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1021\/jm100556b","volume":"53","author":"Coter\u00f3n","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0150","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/med.20163","volume":"30","author":"Ettari","year":"2010","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2015.02.062_b0155","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1016\/j.bmcl.2008.05.068","volume":"18","author":"Verissimo","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.02.062_b0160","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1128\/AAC.47.12.3810-3814.2003","volume":"47","author":"Lee","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2015.02.062_b0165","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1021\/ci050085t","volume":"45","author":"Marrero-Ponce","year":"2005","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmc.2015.02.062_b0170","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1021\/ci2005516","volume":"52","author":"Shah","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmc.2015.02.062_b0175","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1021\/jm900047j","volume":"52","author":"Ettari","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0180","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1002\/cmdc.201200274","volume":"7","author":"Ettari","year":"2012","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2015.02.062_b0185","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s10822-012-9596-4","volume":"26","author":"Grazioso","year":"2012","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.bmc.2015.02.062_b0190","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1016\/j.ejmech.2011.02.061","volume":"46","author":"Rizzi","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0195","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.chembiol.2012.09.020","volume":"19","author":"Stolze","year":"2012","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmc.2015.02.062_b0200","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1021\/jm300588j","volume":"56","author":"Tadigoppula","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0205","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1021\/jm8013663","volume":"52","author":"Kerr","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0210","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1742-4658.2008.06824.x","volume":"276","author":"Redzynia","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.bmc.2015.02.062_b0215","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1021\/jm049933m","volume":"47","author":"Tervo","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0220","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1021\/ci034231b","volume":"44","author":"Hert","year":"2004","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bmc.2015.02.062_b0225","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10822-011-9533-y","volume":"26","author":"Spitzer","year":"2012","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.bmc.2015.02.062_b0230","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1021\/ci800293n","volume":"49","author":"Hevener","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmc.2015.02.062_b0235","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/bip.360330507","volume":"33","author":"Pozna\u0144ski","year":"1993","journal-title":"Biopolymers"},{"key":"10.1016\/j.bmc.2015.02.062_b0240","doi-asserted-by":"crossref","first-page":"15855","DOI":"10.1021\/ja036471d","volume":"125","author":"Sandvoss","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2015.02.062_b0245","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0006-3495(04)74088-6","volume":"86","author":"Deupi","year":"2004","journal-title":"Biophys. J."},{"key":"10.1016\/j.bmc.2015.02.062_b0250","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.carres.2008.12.024","volume":"344","author":"Zhang","year":"2009","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.bmc.2015.02.062_b0255","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1021\/jo0485841","volume":"70","author":"Achkar","year":"2005","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0260","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1046\/j.1365-2958.2002.03105.x","volume":"45","author":"Malhotra","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bmc.2015.02.062_b0265","doi-asserted-by":"crossref","first-page":"408","DOI":"10.2174\/156802612799362913","volume":"12","author":"Marco","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0270","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.146.1.277","volume":"146","author":"Miller","year":"1977","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bmc.2015.02.062_b0275","doi-asserted-by":"crossref","first-page":"29000","DOI":"10.1074\/jbc.M004459200","volume":"275","author":"Shenai","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2015.02.062_b0280","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbrc.2004.02.177","volume":"317","author":"Kumar","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmc.2015.02.062_b0285","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.bmc.2015.02.062_b0290","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","volume":"65","author":"Lambros","year":"1979","journal-title":"J. Parasitol."},{"key":"10.1016\/j.bmc.2015.02.062_b0295","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1128\/AAC.48.5.1803-1806.2004","volume":"48","author":"Smilkstein","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2015.02.062_b0300","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1365-2958.2010.07251.x","volume":"77","author":"Rathore","year":"2010","journal-title":"Mol. Microbiol."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615001789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615001789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:33:16Z","timestamp":1760833996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089615001789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":60,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0968089615001789"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2015.02.062","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2015.02.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}