{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:54:11Z","timestamp":1785894851279,"version":"3.56.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.bmc.2015.03.081","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T13:11:10Z","timestamp":1428412270000},"page":"2303-2309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["The \u03b2-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides"],"prefix":"10.1016","volume":"23","author":[{"given":"Leo","family":"Syrj\u00e4nen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Kuuslahti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martti","family":"Tolvanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Vullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Parkkila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2015.03.081_b0005","doi-asserted-by":"crossref","first-page":"f2900","DOI":"10.1136\/bmj.f2900","volume":"346","author":"Whitty","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.bmc.2015.03.081_h0010","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/cr050262p","volume":"108","author":"Krishnamurthy","year":"2008","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2015.03.081_h0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/14756366.2012.737323","volume":"28","author":"Aggarwal","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14756360902784425","volume":"24","author":"Ebbesen","year":"2009","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0025","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature06636","volume":"452","author":"Xu","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2015.03.081_h0030","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/435042a","volume":"435","author":"Lane","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2015.03.081_h0035","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.bmcl.2013.11.021","volume":"24","author":"Vullo","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.03.081_h0040","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/14756366.2013.761876","volume":"28","author":"Supuran","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0045","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2015.03.081_h0050","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","volume":"27","author":"Supuran","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_b0025","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1021\/bi802246s","volume":"48","author":"Macauley","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2015.03.081_h0060","doi-asserted-by":"crossref","first-page":"6683","DOI":"10.1074\/jbc.M311648200","volume":"279","author":"Tripp","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0065","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2174\/138161208783877929","volume":"14","author":"Zimmerman","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2015.03.081_h0070","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1016\/j.bmcl.2014.08.015","volume":"24","author":"Del Prete","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.03.081_h0075","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.bmc.2014.12.009","volume":"23","author":"Vullo","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0080","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2015.03.081_h0085","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2015.03.081_h0090","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jmb.2008.11.037","volume":"385","author":"Schlicker","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2015.03.081_h0095","doi-asserted-by":"crossref","first-page":"25475","DOI":"10.1074\/jbc.M804726200","volume":"283","author":"Moya","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0100","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2091-11-28","volume":"11","author":"Syrjanen","year":"2010","journal-title":"BMC Biochem."},{"key":"10.1016\/j.bmc.2015.03.081_h0105","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1016\/j.bmcl.2014.04.117","volume":"24","author":"Parkkila","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.03.081_b0050","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1007\/s11033-009-9857-z","volume":"37","author":"Fasseas","year":"2010","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bmc.2015.03.081_h0115","doi-asserted-by":"crossref","first-page":"7372","DOI":"10.1021\/jm400939k","volume":"56","author":"Syrjanen","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0120","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1517\/13543776.2013.778245","volume":"23","author":"Capasso","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2015.03.081_b0060","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1242\/jeb.01287","volume":"207","author":"Seron","year":"2004","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.bmc.2015.03.081_b0065","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1242\/jeb.008342","volume":"210","author":"Smith","year":"2007","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.bmc.2015.03.081_b0070","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2174\/138161208783877901","volume":"14","author":"Krungkrai","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2015.03.081_h0140","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1021\/jm4000616","volume":"56","author":"Pan","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0145","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1021\/jm400418p","volume":"56","author":"G\u00fczel-Akdemir","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_b0080","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bmc.2015.03.081_b0085","unstructured":"Zolfaghari Emameh, R.; Syrj\u00e4nen, L.; Barker, H.; Supuran, C.T.; Parkkila, S. J. Enzyme Inhib. Med. Chem. 2015, in press (doi: 10.3109\/14756366.2014.944178)."},{"key":"10.1016\/j.bmc.2015.03.081_h0160","doi-asserted-by":"crossref","first-page":"27799","DOI":"10.1074\/jbc.M800938200","volume":"283","author":"Hilvo","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0165","doi-asserted-by":"crossref","first-page":"84","DOI":"10.18632\/oncotarget.422","volume":"3","author":"McDonald","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.bmc.2015.03.081_b0095","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/emboj\/19.7.1407","volume":"19","author":"Kimber","year":"2000","journal-title":"EMBO. J."},{"key":"10.1016\/j.bmc.2015.03.081_h0175","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1074\/jbc.M414348200","volume":"280","author":"Suarez Covarrubias","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0180","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1074\/jbc.M510756200","volume":"281","author":"Covarrubias","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_b0105","doi-asserted-by":"crossref","first-page":"10299","DOI":"10.1074\/jbc.M009182200","volume":"276","author":"Strop","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_b0110","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0195","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1021\/jm3004587","volume":"55","author":"Durdagi","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0200","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/jm0512600","volume":"49","author":"Nishimori","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0205","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3109\/14756366.2013.787422","volume":"29","author":"Capasso","year":"2014","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0210","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1517\/17460441.2013.795145","volume":"8","author":"De Simone","year":"2013","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.bmc.2015.03.081_h0215","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fphar.2011.00034","volume":"2","author":"Supuran","year":"2011","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bmc.2015.03.081_h0220","first-page":"49","volume":"2","author":"Supuran","year":"2004","journal-title":"Curr. Med. Chem. Cardiovasc. Hematol. Agents"},{"key":"10.1016\/j.bmc.2015.03.081_h0225","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0223-5234(99)80039-7","volume":"34","author":"Supuran","year":"1999","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0230","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/14756360310001624948","volume":"20","author":"Chohan","year":"2005","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0235","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/1475636021000006261","volume":"17","author":"Chohan","year":"2002","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0240","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3109\/14756366.2011.650168","volume":"28","author":"Maresca","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0245","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3109\/14756366.2011.645539","volume":"28","author":"Maresca","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0250","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.bmc.2012.05.053","volume":"21","author":"Cottier","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0255","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1021\/jm300203r","volume":"55","author":"Hewitson","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0260","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1517\/13543776.2013.794788","volume":"23","author":"Masini","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2015.03.081_h0265","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.03.081_h0270","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2174\/156802607780636726","volume":"7","author":"Thiry","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0275","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1517\/13543776.2013.790957","volume":"23","author":"Scozzafava","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2015.03.081_h0280","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1517\/13543776.2012.707646","volume":"22","author":"Aggarwal","year":"2012","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2015.03.081_h0285","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1517\/13543776.2013.780598","volume":"23","author":"Carta","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2015.03.081_h0290","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1517\/13543776.2012.649006","volume":"22","author":"Carta","year":"2012","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2015.03.081_h0295","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1517\/13543776.2013.782394","volume":"23","author":"Aggarwal","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2015.03.081_h0300","doi-asserted-by":"crossref","unstructured":"Supuran, C.T.; McKenna, R. Carbonic Anhydrase Inhibitors Drug Design, in Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications, McKenna, R.; Frost, S. Eds., Springer, Heidelberg, 2014, pp. 291\u2013323 (Subcell. Biochem. 2014, 75, 291\u2013323)","DOI":"10.1007\/978-94-007-7359-2_15"},{"key":"10.1016\/j.bmc.2015.03.081_h0305","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0960-894X(00)00722-8","volume":"11","author":"Scozzafava","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.03.081_h0310","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0223-5234(99)80096-8","volume":"34","author":"Clare","year":"1999","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0315","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0223-5234(98)80042-1","volume":"33","author":"Supuran","year":"1998","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0320","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3109\/14756366.2011.597749","volume":"27","author":"Fabrizi","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_h0325","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3109\/14756366.2012.700640","volume":"28","author":"Harju","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.03.081_b0150","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.bmc.2015.03.081_b0155","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","volume":"28","author":"Tamura","year":"2011","journal-title":"Mol. Biol. Evol."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615002771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615002771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:30:08Z","timestamp":1760833808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089615002771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0968089615002771"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2015.03.081","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The \u03b2-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2015.03.081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}