{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T18:09:34Z","timestamp":1776535774842,"version":"3.51.2"},"reference-count":56,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["2G12MD007595"],"award-info":[{"award-number":["2G12MD007595"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.bmc.2015.06.012","type":"journal-article","created":{"date-parts":[[2015,6,14]],"date-time":"2015-06-14T13:12:27Z","timestamp":1434287547000},"page":"4489-4500","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pentamidine analogs as inhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors"],"prefix":"10.1016","volume":"23","author":[{"given":"Michael L.","family":"Berger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Maciejewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Jacques","family":"Vanden Eynde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhusoodanan","family":"Mottamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"\u017babi\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Ka\u017amierczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateusz","family":"Rezler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Jarak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Piantanida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Karminski-Zamola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Mayence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Rebernik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Boykin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien L.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2015.06.012_b0005","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.pt.2012.12.005","volume":"29","author":"Baker","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.bmc.2015.06.012_b0010","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1021\/jm00024a001","volume":"38","author":"Queener","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0015","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/brain\/awh130","volume":"127","author":"Valle","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.bmc.2015.06.012_b0020","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/j.1742-4658.2012.08500.x","volume":"279","author":"Kandanearatchi","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.bmc.2015.06.012_b0025","doi-asserted-by":"crossref","first-page":"13732","DOI":"10.1021\/ja074560a","volume":"129","author":"Munde","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2015.06.012_b0030","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/j.ejmech.2010.01.047","volume":"45","author":"\u017bo\u0142ek","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0035","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1523\/JNEUROSCI.12-03-00970.1992","volume":"12","author":"Reynolds","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bmc.2015.06.012_b0040","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0014-2999(98)00386-0","volume":"353","author":"Wood","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2015.06.012_b0045","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.neuropharm.2010.01.011","volume":"58","author":"Chen","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmc.2015.06.012_b0050","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1111\/j.1476-5381.2010.00658.x","volume":"159","author":"De Boer","year":"2010","journal-title":"Brit. J. Pharmacol."},{"key":"10.1016\/j.bmc.2015.06.012_b0055","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/j.bmc.2014.02.049","volume":"22","author":"Huang","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0060","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1111\/j.1460-9568.2011.07628.x","volume":"33","author":"Paoletti","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bmc.2015.06.012_b0065","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/j.1742-4658.2012.08485.x","volume":"279","author":"Guillemin","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.bmc.2015.06.012_b0070","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1124\/jpet.108.149872","volume":"329","author":"Sanderson","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2015.06.012_b0075","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0223-5234(99)80102-0","volume":"34","author":"Tao","year":"1999","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0080","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0960-894X(99)00184-5","volume":"9","author":"Tao","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.012_b0085","series-title":"Current Topics in Medicinal Chemistry","first-page":"51","author":"Berger","year":"2003"},{"key":"10.1016\/j.bmc.2015.06.012_b0090","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1038\/emboj.2011.203","volume":"30","author":"Mony","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.bmc.2015.06.012_b0095","doi-asserted-by":"crossref","first-page":"7104","DOI":"10.1073\/pnas.83.18.7104","volume":"83","author":"Wong","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.06.012_b0100","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0922-4106(94)90211-9","volume":"266","author":"Hashimoto","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2015.06.012_b0105","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nature10180","volume":"475","author":"Karakas","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2015.06.012_b0110","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1124\/jpet.112.192286","volume":"343","author":"Tomitori","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2015.06.012_b0115","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00706-006-0515-z","volume":"137","author":"Maciejewska","year":"2006","journal-title":"Monatsh. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0120","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.molstruc.2010.09.008","volume":"984","author":"\u017babi\u0144ski","year":"2010","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bmc.2015.06.012_b0125","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.molstruc.2009.02.015","volume":"923","author":"\u017babi\u0144ski","year":"2009","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bmc.2015.06.012_b0130","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ejmech.2011.12.010","volume":"48","author":"Maciejewska","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0135","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1016\/j.bmcl.2014.04.075","volume":"24","author":"Maciejewska","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.012_b0140","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1021\/jm00166a026","volume":"33","author":"Tidwell","year":"1990","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0145","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1016\/S0960-894X(01)00541-8","volume":"11","author":"Huang","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.012_b0150","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1128\/AAC.48.11.4209-4216.2004","volume":"48","author":"Cushion","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2015.06.012_b0155","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1016\/j.ejmech.2010.03.044","volume":"45","author":"Vamecq","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0160","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.1016\/j.bmcl.2004.06.034","volume":"14","author":"Vanden Eynde","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.012_b0165","doi-asserted-by":"crossref","first-page":"5884","DOI":"10.1016\/j.bmcl.2009.08.073","volume":"19","author":"Huang","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.012_b0170","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/j.ejmech.2011.04.001","volume":"46","author":"Jarak","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0175","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1021\/jm970570i","volume":"41","author":"Boykin","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0180","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1021\/jm060470p","volume":"49","author":"Ismail","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0185","doi-asserted-by":"crossref","first-page":"13659","DOI":"10.1021\/ja048175m","volume":"126","author":"Mallena","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2015.06.012_b0190","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1128\/AAC.02024-13","volume":"58","author":"Giordani","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2015.06.012_b0195","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ejmech.2006.11.006","volume":"42","author":"Gonzales","year":"2007","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0200","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0922-4106(93)90023-3","volume":"224","author":"Reynolds","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2015.06.012_b0205","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0223-5234(99)80070-1","volume":"33","author":"Berger","year":"1998","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.012_b0210","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1016\/j.bmcl.2006.03.015","volume":"16","author":"Berger","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.012_b0215","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1016\/S0960-894X(98)00631-3","volume":"8","author":"Sharma","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.012_b0220","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/S0960-894X(97)00240-0","volume":"7","author":"Donkor","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.012_b0225","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1469-7793.1998.017bf.x","volume":"512","author":"Kew","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.bmc.2015.06.012_b0230","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1126\/science.7754371","volume":"268","author":"Traynelis","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bmc.2015.06.012_b0235","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/cmdc.201200470","volume":"8","author":"Berger","year":"2013","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2015.06.012_b0240","doi-asserted-by":"crossref","first-page":"9150","DOI":"10.1523\/JNEUROSCI.0829-13.2013","volume":"33","author":"Tovar","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bmc.2015.06.012_b0245","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.neuron.2014.01.035","volume":"81","author":"Hansen","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.bmc.2015.06.012_b0250","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/S0022-3565(24)38309-0","volume":"289","author":"Berger","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2015.06.012_b0255","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0022-3565(24)38233-3","volume":"289","author":"Sharma","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2015.06.012_b0260","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/00397910903537364","volume":"41","author":"Ismail","year":"2011","journal-title":"Synth. Commun."},{"key":"10.1016\/j.bmc.2015.06.012_b0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0076-6879(92)10003-V","volume":"210","author":"Johnson","year":"1992","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bmc.2015.06.012_b0270","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1126\/science.1251915","volume":"344","author":"Karakas","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bmc.2015.06.012_b0275","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature13548","volume":"511","author":"Lee","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2015.06.012_b0280","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1006\/jmbi.1996.0897","volume":"267","author":"Jones","year":"1997","journal-title":"J. Mol. Biol."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615005064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615005064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:39:00Z","timestamp":1760834340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089615005064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":56,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0968089615005064"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2015.06.012","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pentamidine analogs as inhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2015.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}