{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:27:09Z","timestamp":1777566429267,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004477","name":"Stellenbosch University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004477","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NRF"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.bmc.2015.06.044","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T02:58:01Z","timestamp":1435719481000},"page":"4163-4171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["In vitro antiplasmodial activity of triazole-linked chloroquinoline derivatives synthesized from 7-chloro-N-(prop-2-yn-1-yl)quinolin-4-amine"],"prefix":"10.1016","volume":"23","author":[{"given":"Lebusetsa","family":"Taleli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"de Kock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Pelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A.L.","family":"Blackie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem A.L.","family":"van Otterlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2015.06.044_b0005","unstructured":"WHO. In World Malaria Report., http:\/\/www.who.int\/entity\/malaria\/world_malaria_report_2011\/9789241564403_eng.pdf., [accessed 08\/2014], 2011."},{"key":"10.1016\/j.bmc.2015.06.044_b0010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1021\/jm990437l","volume":"43","author":"Egan","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0015","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1021\/jm020858u","volume":"45","author":"Kaschula","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0020","series-title":"Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery","first-page":"87","author":"Tilley","year":"2001"},{"key":"10.1016\/j.bmc.2015.06.044_b0025","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2174\/092986711793979742","volume":"18","author":"Muregi","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0030","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1016\/j.ejmech.2009.02.024","volume":"44","author":"Kouznetsov","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0035","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1371\/journal.pctr.0020006","volume":"2","author":"Mzayek","year":"2007","journal-title":"PLoS Clin. Trials"},{"key":"10.1016\/j.bmc.2015.06.044_b0040","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1021\/jm8012618","volume":"52","author":"O\u2019Neill","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_h0045","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2174\/156802606776743147","volume":"6","author":"O\u2019Neill","year":"2006","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_h0050","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1128\/AAC.40.8.1846","volume":"40","author":"Ridley","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2015.06.044_b0050","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1021\/jm060399n","volume":"49","author":"Burgess","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0055","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2174\/156802612799362968","volume":"12","author":"Peyton","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0060","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1021\/jm900972u","volume":"53","author":"Andrews","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0065","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.1021\/jm1006484","volume":"53","author":"Burgess","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0070","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ar7000843","volume":"41","author":"Meunier","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bmc.2015.06.044_b0075","doi-asserted-by":"crossref","first-page":"6956","DOI":"10.1021\/jm2009698","volume":"54","author":"Zishiri","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0080","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1016\/j.bmcl.2010.09.107","volume":"20","author":"Kumar","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.044_b0085","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1021\/jm980146x","volume":"41","author":"De","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0090","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1021\/jm0108707","volume":"45","author":"Stocks","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0095","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1016\/j.bmcl.2014.10.015","volume":"24","author":"Hamann","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.044_b0100","first-page":"231","volume":"66","author":"Hamann","year":"2013","journal-title":"Afr. J. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0105","first-page":"135","volume":"1037","author":"Gildenhuys","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2015.06.044_b0110","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/092986712803414213","volume":"19","author":"Zhou","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0115","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.bmcl.2013.12.109","author":"Raj","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.044_b0120","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ejmech.2013.11.022","volume":"73","author":"Pereira","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0125","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ejmech.2013.01.032","volume":"62","author":"Raj","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0130","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ejmech.2013.08.046","volume":"69","author":"Joshi","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0135","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/cbdd.12335","volume":"84","author":"Fischer","year":"2014","journal-title":"Chem. Biol. Drug Discovery"},{"key":"10.1016\/j.bmc.2015.06.044_b0140","first-page":"56","volume":"22","author":"Singh","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.044_b0145","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1021\/jm200149e","volume":"54","author":"Guantai","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0150","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/cbdd.12321","volume":"84","author":"Boechat","year":"2014","journal-title":"Chem. Biol. Drug Disc."},{"key":"10.1016\/j.bmc.2015.06.044_b0155","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1021\/jm701478a","volume":"51","author":"Natarajan","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0160","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1021\/jm040800a","volume":"47","author":"Tahtaoui","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0165","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1021\/ja00223a069","volume":"110","author":"DePue","year":"1988","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2015.06.044_b0170","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/hc.20030","volume":"15","author":"Al-Masoudi","year":"2004","journal-title":"Heteroatom. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0175","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1021\/ci0200265","volume":"42","author":"Bhattacharjee","year":"2002","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bmc.2015.06.044_b0180","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1126\/science.3544220","volume":"235","author":"Martin","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.bmc.2015.06.044_b0185","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1126\/science.3317830","volume":"238","author":"Krogstad","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.bmc.2015.06.044_b0190","first-page":"807","volume":"54","author":"Cegielska","year":"2009","journal-title":"Chem. Anal."},{"key":"10.1016\/j.bmc.2015.06.044_b0195","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1016\/S0960-894X(01)00626-6","volume":"11","author":"Gu","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.06.044_b0200","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1021\/jo00380a019","volume":"52","author":"Conrad","year":"1987","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0205","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1021\/jm8003834","volume":"51","author":"Nagase","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0210","doi-asserted-by":"crossref","first-page":"8177","DOI":"10.1016\/S0040-4020(01)91013-0","volume":"47","author":"Benalil","year":"1991","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2015.06.044_b0215","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1021\/jm1013488","volume":"54","author":"Wijtmans","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0220","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1002\/chem.201003157","volume":"17","author":"Dash","year":"2011","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.bmc.2015.06.044_b0225","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1039\/b923882d","volume":"8","author":"Le Corre","year":"2010","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0230","doi-asserted-by":"crossref","first-page":"9562","DOI":"10.1021\/jm300837y","volume":"55","author":"Suzuki","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0235","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.tetlet.2004.10.002","volume":"45","author":"Romera","year":"2004","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2015.06.044_b0240","unstructured":"Guillemont, J. E. G.; Pasquire, E. T. J.; Lancois, D. F. A.; WO 2005\/070430 A1 2005, 88."},{"key":"10.1016\/j.bmc.2015.06.044_b0245","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/jhet.5570190667","volume":"19","author":"Gozlan","year":"1982","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.bmc.2015.06.044_b0250","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1016\/j.tetlet.2011.09.004","volume":"52","author":"Stefani","year":"2011","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2015.06.044_b0255","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.bmc.2015.06.044_b0260","doi-asserted-by":"crossref","first-page":"739","DOI":"10.4269\/ajtmh.1993.48.739","volume":"48","author":"Makler","year":"1993","journal-title":"Am. J. Trop. Med. Hyg."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615005386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615005386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:37:10Z","timestamp":1760834230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089615005386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":53,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0968089615005386"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2015.06.044","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro antiplasmodial activity of triazole-linked chloroquinoline derivatives synthesized from 7-chloro-N-(prop-2-yn-1-yl)quinolin-4-amine","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2015.06.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}