{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:05:38Z","timestamp":1790330738509,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.bmc.2015.07.047","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T17:40:01Z","timestamp":1438191601000},"page":"6223-6227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents"],"prefix":"10.1016","volume":"23","author":[{"given":"Marco","family":"Bragagni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Bozdag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Carta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Lanzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Masini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Mura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2015.07.047_b0005","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1021\/js950534b","volume":"85","author":"Loftsson","year":"1996","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bmc.2015.07.047_b0010","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.jpba.2010.12.009","volume":"54","author":"Jug","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bmc.2015.07.047_b0015","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jpba.2013.11.009","volume":"89","author":"Mennini","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bmc.2015.07.047_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2006.10.044","volume":"329","author":"Loftsson","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bmc.2015.07.047_b0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jpba.2009.11.013","volume":"52","author":"Jug","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bmc.2015.07.047_b0030","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1002\/jps.22068","volume":"99","author":"Mura","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bmc.2015.07.047_b0035","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3109\/03639049709148496","volume":"23","author":"Loftsson","year":"1997","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.bmc.2015.07.047_b0040","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0169-409X(98)00055-6","volume":"36","author":"Loftsson","year":"1999","journal-title":"Adv. Drug Del. Rev."},{"key":"10.1016\/j.bmc.2015.07.047_b0045","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1034\/j.1600-0420.2002.800205.x","volume":"80","author":"Loftsson","year":"2002","journal-title":"Acta Ophthalmol. Scand."},{"key":"10.1016\/j.bmc.2015.07.047_b0050","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/jps.10215","volume":"91","author":"Maestrelli","year":"2002","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.bmc.2015.07.047_b0055","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ejpb.2010.07.005","volume":"76","author":"Jansook","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bmc.2015.07.047_h0060","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0968-0896(00)00143-7","volume":"8","author":"Ilies","year":"2000","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.047_h0065","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2174\/138161208783877866","volume":"14","author":"Mincione","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2015.07.047_h0070","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0223-5234(97)86179-X","volume":"31","author":"Briganti","year":"1996","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.047_b0065","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1021\/jm501314c","volume":"57","author":"Bozdag","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.047_h0080","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bmc.2015.07.047_h0085","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bmc.2015.07.047_h0090","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/978-94-007-7359-2_17","volume":"75","author":"Scozzafava","year":"2014","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.bmc.2015.07.047_h0095","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","volume":"27","author":"Supuran","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.047_h0100","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1517\/13543776.2013.794788","volume":"23","author":"Masini","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.bmc.2015.07.047_b0075","first-page":"117","volume":"4","author":"Higuchi","year":"1965","journal-title":"Adv. Anal. Chem. Instrum."},{"key":"10.1016\/j.bmc.2015.07.047_b0080","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2015.07.047_h0115","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1039\/c2cc16395k","author":"Carta","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmc.2015.07.047_h0120","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3109\/14756366.2012.727410","volume":"28","author":"Avram","year":"2013","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.047_h0125","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1021\/jm300031j","volume":"55","author":"Carta","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.047_h0130","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0223-5234(99)80039-7","volume":"34","author":"Supuran","year":"1999","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.047_h0135","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3109\/14756369909030328","volume":"14","author":"Scozzafava","year":"1999","journal-title":"J. Enzyme Inhib."},{"key":"10.1016\/j.bmc.2015.07.047_h0140","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bmc.2013.11.016","volume":"22","author":"Bozdag","year":"2014","journal-title":"Bioorg Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.047_h0145","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1021\/jm9900523","volume":"42","author":"Scozzafava","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.047_h0150","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.exer.2011.03.001","volume":"93","author":"Krauss","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bmc.2015.07.047_h0155","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3109\/14756366.2011.597749","volume":"27","author":"Fabrizi","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.047_h0160","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.2174\/092986707782360141","volume":"14","author":"Mastrolorenzo","year":"2007","journal-title":"Curr. Med. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615006318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615006318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:34:05Z","timestamp":1760834045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089615006318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":32,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0968089615006318"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2015.07.047","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2015.07.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}