{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:04:19Z","timestamp":1760853859736,"version":"build-2065373602"},"reference-count":28,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"U.S. Public Health Service NIDA","award":["314450 NIDA 2P01 DA006284"],"award-info":[{"award-number":["314450 NIDA 2P01 DA006284"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.bmc.2015.07.071","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T02:02:16Z","timestamp":1438912936000},"page":"6185-6194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands"],"prefix":"10.1016","volume":"23","author":[{"given":"Srinivas","family":"Deekonda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Wugalter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tally M.","family":"Largent-Milnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peg","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neemah M.","family":"Bassirirad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd W.","family":"Vanderah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Porreca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor J.","family":"Hruby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2015.07.071_b0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-6147(98)01279-6","volume":"20","author":"Kieffer","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bmc.2015.07.071_b0010","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/med.10059","volume":"24","author":"Eguchi","year":"2004","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2015.07.071_b0015","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1021\/jm400050y","volume":"56","author":"Mosberg","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.071_b0020","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/cbdd.12014","volume":"80","author":"Anand","year":"2012","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bmc.2015.07.071_b0025","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1016\/S0960-894X(98)00472-7","volume":"8","author":"Wang","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.07.071_b0030","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/bja\/34.4.260","volume":"34","author":"Janssen","year":"1962","journal-title":"Br. J. Anaesthesia"},{"key":"10.1016\/j.bmc.2015.07.071_h0035","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.2174\/092986712799945030","volume":"19","author":"Gentilucci","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.071_h0040","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.2174\/0929867023369394","volume":"9","author":"Kaczor","year":"2002","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.071_b0040","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1021\/jm9019068","volume":"53","author":"Weltrowska","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.071_b0045","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.2174\/092986709788682074","volume":"16","author":"Vuc\u02c7kovi\u0107","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.071_b0050","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0968-0896(01)00345-5","volume":"10","author":"Jagerovic","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.071_b0055","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4155\/fmc.13.215","volume":"6","author":"Vardanyan","year":"2014","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.071_b0060","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.lfs.2013.09.016","volume":"93","author":"Podolsky","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.bmc.2015.07.071_b0065","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1021\/jm9903702","volume":"43","author":"Subramanian","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.071_b0070","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/med.2610110404","volume":"11","author":"Bagley","year":"1991","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2015.07.071_b0075","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1021\/jm00357a007","volume":"26","author":"Essawi","year":"1983","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.071_b0080","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.bmcl.2007.01.114","volume":"17","author":"Lee","year":"2007","journal-title":"J. Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.07.071_b0085","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1016\/j.bmcl.2006.06.040","volume":"16","author":"Petrov","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.07.071_b0090","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1021\/jm061465o","volume":"50","author":"Lee","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.071_b0095","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1021\/jm100982d","volume":"54","author":"Lee","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.07.071_b0100","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1016\/j.bmcl.2013.03.065","volume":"23","author":"Petrov","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.07.071_b0105","unstructured":"Dan, P.; Birgitte, E. L.; Gordon, M.; Ostergaard, N. E.; Paul, R. J. WO 2007093603 2007."},{"key":"10.1016\/j.bmc.2015.07.071_b0110","unstructured":"Ben, A.C.; Toshihiro, A.; Kaustav, B.; Jian, C. J.; Brooks, H. J.; Wenyuan, Q. WO 2006041888 2006."},{"key":"10.1016\/j.bmc.2015.07.071_b0115","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1021\/ja00252a056","volume":"109","author":"Corey","year":"1987","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2015.07.071_b0120","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0024-3205(92)90501-F","volume":"51","author":"Misicka","year":"1992","journal-title":"Life Sci."},{"key":"10.1016\/j.bmc.2015.07.071_b0125","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0022-3565(25)38420-X","volume":"266","author":"Kramer","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2015.07.071_b0130","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0031-9384(76)90029-9","volume":"17","author":"Yaksh","year":"1976","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bmc.2015.07.071_b0135","first-page":"3277","author":"Hargreaves","year":"1988","journal-title":"Pain"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615006550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615006550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:33:14Z","timestamp":1760833994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089615006550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":28,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0968089615006550"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2015.07.071","relation":{},"ISSN":["0968-0896"],"issn-type":[{"type":"print","value":"0968-0896"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2015.07.071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}