{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:39:09Z","timestamp":1791981549345,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.bmc.2015.09.023","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T04:21:51Z","timestamp":1442290911000},"page":"6560-6572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Molecular modeling studies and synthesis of novel quinoxaline derivatives with potential anticancer activity as inhibitors of c-Met kinase"],"prefix":"10.1016","volume":"23","author":[{"given":"Hebat-Allah S.","family":"Abbas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha R.","family":"Al-Marhabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally I.","family":"Eissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousry A.","family":"Ammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2015.09.023_b0005","first-page":"56","volume":"8","author":"Ali","year":"2011","journal-title":"Cancer Ther."},{"key":"10.1016\/j.bmc.2015.09.023_b0010","first-page":"6","volume":"8","author":"Ali","year":"2011","journal-title":"Cancer Ther."},{"key":"10.1016\/j.bmc.2015.09.023_b0015","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/156800911794328457","volume":"11","author":"Ali","year":"2011","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.bmc.2015.09.023_b0020","doi-asserted-by":"crossref","first-page":"961","DOI":"10.4155\/fmc.13.62","volume":"5","author":"Ali","year":"2013","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bmc.2015.09.023_b0025","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2174\/1389450116666150309115922","volume":"16","author":"Ali","year":"2015","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bmc.2015.09.023_b0030","first-page":"281","volume":"5","author":"Abbas","year":"2014","journal-title":"J. Mater. Environ. Sci."},{"key":"10.1016\/j.bmc.2015.09.023_b0035","first-page":"497","volume":"2","author":"Suresh","year":"2010","journal-title":"J. Chem. Pharm. Res."},{"key":"10.1016\/j.bmc.2015.09.023_b0040","first-page":"368","volume":"2","author":"Raoa","year":"2010","journal-title":"J. Chem. Pharm. Res."},{"key":"10.1016\/j.bmc.2015.09.023_b0045","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s00436-013-3298-2","volume":"112","author":"Rivera","year":"2013","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.bmc.2015.09.023_b0050","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1016\/S0968-0896(03)00399-7","volume":"11","author":"Li","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2015.09.023_b0055","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.exppara.2011.01.009","volume":"127","author":"Estevez","year":"2011","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.bmc.2015.09.023_b0060","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1021\/jm000282d","volume":"44","author":"Lawrence","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.09.023_b0065","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1016\/j.bmcl.2006.09.040","volume":"16","author":"Kotharkar","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.09.023_b0070","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0014-827X(03)00198-8","volume":"58","author":"Carta","year":"2003","journal-title":"Farmaco"},{"key":"10.1016\/j.bmc.2015.09.023_b0075","first-page":"260","volume":"3","author":"Ghadage","year":"2011","journal-title":"J. Chem. Pharm. Res."},{"key":"10.1016\/j.bmc.2015.09.023_b0080","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bmc.2009.10.064","volume":"18","author":"Ajani","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2015.09.023_b0085","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1080\/10426500500366947","volume":"181","author":"El-Gaby","year":"2006","journal-title":"Phosphorus Sulfur Silicon"},{"key":"10.1016\/j.bmc.2015.09.023_b0090","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3390\/50600864","volume":"5","author":"Ali","year":"2000","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2015.09.023_b0095","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0014-827X(01)01161-2","volume":"56","author":"Carta","year":"2001","journal-title":"Farmaco"},{"key":"10.1016\/j.bmc.2015.09.023_b0100","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/s00044-009-9203-y","volume":"18","author":"El-Sabbagh","year":"2009","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.bmc.2015.09.023_b0105","first-page":"169","volume":"66","author":"Khan","year":"2009","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/j.bmc.2015.09.023_b0110","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.1016\/j.bmcl.2007.10.002","volume":"17","author":"Burguete","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.09.023_b0115","first-page":"689","volume":"63","author":"Ismail","year":"2006","journal-title":"Afinidad"},{"key":"10.1016\/j.bmc.2015.09.023_b0120","first-page":"738","volume":"55","author":"Ismail","year":"2006","journal-title":"Arzneim.-Forsch.\/Drug Res."},{"key":"10.1016\/j.bmc.2015.09.023_b0125","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1016\/j.bmc.2013.04.018","volume":"21","author":"Ali","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2015.09.023_b0130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2174\/1871520611313020016","volume":"13","author":"Ali","year":"2013","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.bmc.2015.09.023_b0135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2174\/157488512800389164","volume":"7","author":"Ali","year":"2012","journal-title":"Curr. Drug Ther."},{"key":"10.1016\/j.bmc.2015.09.023_b0140","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2174\/156800911794328493","volume":"11","author":"Ali","year":"2011","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.bmc.2015.09.023_b0145","first-page":"133","volume":"9","author":"Ali","year":"2010","journal-title":"Egyptian Pharm."},{"key":"10.1016\/j.bmc.2015.09.023_b0150","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1016\/j.bmc.2006.06.038","volume":"14","author":"Amin","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2015.09.023_b0155","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1016\/j.ejmech.2010.02.052","volume":"45","author":"Ismail","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.09.023_b0160","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3184\/174751911X12983997221326","volume":"163","author":"Farrag","year":"2011","journal-title":"J. Chem. Res."},{"key":"10.1016\/j.bmc.2015.09.023_b0165","first-page":"113","volume":"26","author":"Noureen","year":"2013","journal-title":"Pak. J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.bmc.2015.09.023_b0170","first-page":"2652","article-title":"World","volume":"4","author":"Raju","year":"2015","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.bmc.2015.09.023_b0175","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.farmac.2003.11.014","volume":"59","author":"Piras","year":"2004","journal-title":"Farmaco"},{"key":"10.1016\/j.bmc.2015.09.023_b0180","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.ejmech.2008.07.025","volume":"44","author":"Corona","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.09.023_b0185","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1016\/j.bmcl.2009.06.016","volume":"19","author":"Miyashiro","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.09.023_b0190","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s10637-009-9384-8","volume":"29","author":"Hirai","year":"2011","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.bmc.2015.09.023_b0195","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bfopcu.2012.05.002","volume":"50","author":"Bayoumi","year":"2012","journal-title":"Bull. Faculty Pharm., Cairo Univ."},{"key":"10.1016\/j.bmc.2015.09.023_b0200","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bmcl.2008.11.062","volume":"19","author":"Porter","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.09.023_b0205","doi-asserted-by":"crossref","first-page":"12654","DOI":"10.1073\/pnas.1734128100","volume":"100","author":"Schiering","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.09.023_b0210","author":"Andresen","year":"2013","journal-title":"PCT Int. Appl."},{"key":"10.1016\/j.bmc.2015.09.023_b0215","author":"Ignacio","year":"2013","journal-title":"PCT Int. Appl."},{"key":"10.1016\/j.bmc.2015.09.023_b0220","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.bmcl.2012.11.077","volume":"23","author":"Jose-Ignacio","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.09.023_b0225","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","volume":"82","author":"Shehan","year":"1990","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bmc.2015.09.023_b0230","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/jnci\/83.11.757","volume":"83","author":"Monk","year":"1991","journal-title":"J. Natl. Cancer Inst."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615300481?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615300481?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:33:13Z","timestamp":1760833993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089615300481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":46,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0968089615300481"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2015.09.023","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular modeling studies and synthesis of novel quinoxaline derivatives with potential anticancer activity as inhibitors of c-Met kinase","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2015.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}