{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:09:14Z","timestamp":1771654154048,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Polish National Scientific Centre","award":["DEC-2012\/05\/D\/NZ7\/02328"],"award-info":[{"award-number":["DEC-2012\/05\/D\/NZ7\/02328"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.bmc.2015.12.027","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T01:33:14Z","timestamp":1450488794000},"page":"606-618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones"],"prefix":"10.1016","volume":"24","author":[{"given":"Krzysztof","family":"Kami\u0144ski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miros\u0142aw","family":"Zagaja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Rapacz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarogniew J.","family":"\u0141uszczki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Andres-Mach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Abram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Obniska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2015.12.027_b0005","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.0013-9580.2005.66104.x","volume":"46","author":"Fischer","year":"2005","journal-title":"Epilepsia"},{"key":"10.1016\/j.bmc.2015.12.027_b0010","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/01.wco.0000218235.67840.82","volume":"19","author":"Hitiris","year":"2006","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.bmc.2015.12.027_b0015","unstructured":"Pipeline Insight: Epilepsy\u00a9 Datamonitor, 2006."},{"key":"10.1016\/j.bmc.2015.12.027_b0020","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1586\/ern.10.71","volume":"10","author":"Cramer","year":"2010","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.bmc.2015.12.027_b0025","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrd2997","volume":"9","author":"Bialer","year":"2010","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2015.12.027_b0030","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.eplepsyres.2011.08.016","volume":"98","author":"Khan","year":"2012","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.bmc.2015.12.027_b0035","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1474-4422(14)70076-6","volume":"13","author":"Simonato","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bmc.2015.12.027_b0040","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1021\/jm901614b","volume":"53","author":"Lange","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.12.027_b0045","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1021\/ml5000959","volume":"5","author":"Giacomini","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.12.027_b0050","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ejmech.2014.07.016","volume":"84","author":"Malik","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.12.027_b0055","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S1359-6446(04)03163-0","volume":"9","author":"Morphy","year":"2004","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.bmc.2015.12.027_b0060","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2174\/138161209787315594","volume":"15","author":"Morphy","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bmc.2015.12.027_b0065","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1734-1140(09)70024-6","volume":"61","author":"\u0141uszczki","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bmc.2015.12.027_b0070","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/ana.410250610","volume":"25","author":"Coulter","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bmc.2015.12.027_b0075","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0304-3940(89)90376-5","volume":"98","author":"Coulter","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bmc.2015.12.027_b0080","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1476-5381.1990.tb14095.x","volume":"100","author":"Coulter","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bmc.2015.12.027_b0085","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pharmthera.2006.07.005","volume":"113","author":"Stefan","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bmc.2015.12.027_b0090","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1038\/bjp.2008.198","volume":"154","author":"Matagne","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bmc.2015.12.027_b0095","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1016\/j.ejmech.2011.07.043","volume":"46","author":"Kami\u0144ski","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.12.027_b0100","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.1016\/j.bmcl.2011.07.118","volume":"21","author":"Kami\u0144ski","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2015.12.027_b0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1684\/j.1950-6945.2004.tb00053.x","volume":"6","author":"Spina","year":"2004","journal-title":"Epileptic Disord."},{"key":"10.1016\/j.bmc.2015.12.027_b0110","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1021\/ja01502a038","volume":"82","author":"Paul","year":"1960","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2015.12.027_b0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.eplepsyres.2005.09.012","volume":"68","author":"Rogawski","year":"2006","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.bmc.2015.12.027_b0120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1358\/mf.2009.31.2.1338414","volume":"3","author":"Castel-Branco","year":"2009","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.bmc.2015.12.027_b0125","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.seizure.2011.01.003","volume":"20","author":"L\u00f6scher","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.bmc.2015.12.027_b0130","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0920-1211(01)00302-3","volume":"47","author":"Barton","year":"2001","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.bmc.2015.12.027_b0135","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1021\/acs.jmedchem.5b00578","volume":"58","author":"Kami\u0144ski","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2015.12.027_b0140","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1016\/j.bmc.2015.03.038","volume":"23","author":"Kami\u0144ski","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2015.12.027_b0145","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2170\/jjphysiol.3.46","volume":"3","author":"Hayashi","year":"1952","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.bmc.2015.12.027_b0150","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1749-6632.1995.tb17509.x","volume":"757","author":"Meldrum","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bmc.2015.12.027_b0155","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrn1430","volume":"5","author":"Rogawski","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bmc.2015.12.027_b0160","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev-pharmtox-011112-140232","volume":"54","author":"Catterall","year":"2014","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bmc.2015.12.027_b0165","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1523\/JNEUROSCI.06-07-02064.1986","volume":"6","author":"Brown","year":"1986","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bmc.2015.12.027_b0170","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0006-8993(87)90054-0","volume":"402","author":"Shelton","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.bmc.2015.12.027_b0175","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1211\/002235704777489302","volume":"56","author":"Ku\u0142ak","year":"2004","journal-title":"Pol. J. Pharmacol."},{"key":"10.1016\/j.bmc.2015.12.027_b0180","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1111\/j.1528-1157.2000.tb02163.x","volume":"41","author":"Shank","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.bmc.2015.12.027_b0185","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.neuropharm.2003.11.028","volume":"46","author":"Russo","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmc.2015.12.027_b0190","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1503\/cmaj.060146","volume":"175","author":"Gilron","year":"2006","journal-title":"CMAJ"},{"key":"10.1016\/j.bmc.2015.12.027_b0195","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0304-3959(77)90130-0","volume":"4","author":"Dubuisson","year":"1977","journal-title":"Pain"},{"key":"10.1016\/j.bmc.2015.12.027_b0200","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0304-3959(94)00095-V","volume":"60","author":"Abbott","year":"1995","journal-title":"Pain"},{"key":"10.1016\/j.bmc.2015.12.027_b0205","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1152\/jn.1946.9.3.231","volume":"9","author":"Toman","year":"1946","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bmc.2015.12.027_b0210","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pbb.2003.09.019","volume":"77","author":"Ferreri","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bmc.2015.12.027_b0215","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00702-014-1173-7","volume":"121","author":"Florek-\u0141uszczki","year":"2014","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.bmc.2015.12.027_b0220","first-page":"81","volume":"3","author":"Boissier","year":"1960","journal-title":"Med. Exp."},{"key":"10.1016\/j.bmc.2015.12.027_b0225","series-title":"Molecular and Cellular Targets for Anti-epileptic Drugs","article-title":"The NIH Anticonvulsant Drug Development (ADD) Program: Preclinical Anticonvulsant Screening Project","author":"Stables","year":"1997"},{"key":"10.1016\/j.bmc.2015.12.027_b0230","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","volume":"96","author":"Litchfield","year":"1949","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2015.12.027_b0235","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1124\/jpet.302.3.1168","volume":"302","author":"Laughlin","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bmc.2015.12.027_b0240","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pharep.2014.08.002","volume":"67","author":"Obniska","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bmc.2015.12.027_b0245","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1073\/pnas.79.11.3656","volume":"79","author":"Gould","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bmc.2015.12.027_b0250","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0014-2999(91)90063-V","volume":"192","author":"Sills","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2015.12.027_b0255","series-title":"Antiepileptic Drugs","first-page":"36","article-title":"Discovery and Preclinical Development of Antiepileptic Drugs","author":"White","year":"2002"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615301930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089615301930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:37:25Z","timestamp":1760834245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089615301930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0968089615301930"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2015.12.027","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2015.12.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}