{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:28:14Z","timestamp":1791415694911,"version":"4.3.3"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"am","delay-in-days":359,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006151","name":"U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences","doi-asserted-by":"publisher","award":["DE-AC02-98CH10886"],"award-info":[{"award-number":["DE-AC02-98CH10886"]}],"id":[{"id":"10.13039\/100006151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.bmc.2016.02.014","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T12:41:57Z","timestamp":1455021717000},"page":"1384-1391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists"],"prefix":"10.1016","volume":"24","author":[{"given":"Stephen D.","family":"Lotesta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Leftheris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B.","family":"Noto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Kandpal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"McKeever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Bukhtiyarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak S.","family":"Lala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh B.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard M.","family":"McGeehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2016.02.014_b0005","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/ki.1992.421","volume":"42","author":"Clore","year":"1992","journal-title":"Kidney Int."},{"key":"10.1016\/j.bmc.2016.02.014_b0010","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0039-128X(94)00024-7","volume":"60","author":"Stewart","year":"1995","journal-title":"Steroids"},{"key":"10.1016\/j.bmc.2016.02.014_h0015","first-page":"89","volume":"46","author":"Leftheris","year":"2011","journal-title":"Ann. Rev. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.014_h0020","doi-asserted-by":"crossref","first-page":"7957","DOI":"10.1021\/jm300806c","volume":"55","author":"Piotrowski","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.014_h0025","unstructured":"Fukumoto, S.; Ohyabu. N.; Ohra, T.; Sugimoto, T.; Hasui, T.; Fuji, K.; Siedem, C. S.; Gauthier, C. Patent US 20100094000, April 15, 2010."},{"key":"10.1016\/j.bmc.2016.02.014_h0030","doi-asserted-by":"crossref","first-page":"8616","DOI":"10.1021\/jm2011645","volume":"54","author":"Hasui","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.014_h0035","unstructured":"Coates, A. D.; Konstantinos, G.; Jadhav, P. Patent WO 2010\/104721, Sep 16, 2010."},{"key":"10.1016\/j.bmc.2016.02.014_h0040","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/FJC.0b013e3182495543","volume":"59","author":"Nariai","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bmc.2016.02.014_h0045","unstructured":"Michellys, P.; Petrassi, M. H.; Richmond, W.; Pei, W. Patent WO 2006015259, Feb 9, 2006."},{"key":"10.1016\/j.bmc.2016.02.014_h0050","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1021\/jm701186z","volume":"50","author":"Bell","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.014_h0055","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.1016\/j.bmc.2014.07.038","volume":"22","author":"Hasui","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.014_h0060","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1021\/ci200605k","volume":"52","author":"Ishchenko","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bmc.2016.02.014_h0065","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/cmdc.201200081","volume":"7","author":"Barfacker","year":"2012","journal-title":"Chem. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.014_h0070","doi-asserted-by":"crossref","first-page":"31283","DOI":"10.1074\/jbc.M504098200","volume":"280","author":"Bledsoe","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2016.02.014_h0075","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nsmb939","volume":"12","author":"Fagart","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bmc.2016.02.014_h0080","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.molcel.2005.06.026","volume":"19","author":"Li","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bmc.2016.02.014_h0085","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1124\/mol.107.036459","volume":"72","author":"Huyet","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bmc.2016.02.014_b0030","doi-asserted-by":"crossref","first-page":"28468","DOI":"10.1074\/jbc.M504144200","volume":"280","author":"Zhang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2016.02.014_h0095","unstructured":"Kyle, D. J.; Mavunkel, B. J.; Chakravarty, S.; Lu, Z. Patent US 1998\/5817756A, Oct 6, 1998."},{"key":"10.1016\/j.bmc.2016.02.014_h0100","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1021\/jm201542d","volume":"55","author":"Vachal","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.014_h0105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-1993-22398","author":"Yang","year":"1993","journal-title":"Synlett"},{"key":"10.1016\/j.bmc.2016.02.014_h0110","unstructured":"ClogD values were calculated using Pipeline Pilot version 9.2, Biovia, San Diego, CA."},{"key":"10.1016\/j.bmc.2016.02.014_b0050","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1016\/j.bmc.2011.03.003","volume":"19","author":"Kubota","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.014_h0120","first-page":"13","author":"Majumdar","year":"1881","journal-title":"Synlett"},{"key":"10.1016\/j.bmc.2016.02.014_h0125","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1002\/chem.201002093","volume":"17","author":"Kenwright","year":"2011","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.bmc.2016.02.014_h0130","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1021\/jo100408p","volume":"75","author":"Thansandote","year":"2010","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.bmc.2016.02.014_h0135","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1139\/v90-222","volume":"68","author":"Baum","year":"1990","journal-title":"Can. J. Chem."},{"key":"10.1016\/j.bmc.2016.02.014_h0140","unstructured":"Buhr, W.; Burckhardt, S.; Duerrenberger, F.; Funk, F.; Geisser, P. O.; Corden, V. A.; Courtney, S. M.; Davenport, T.; Slack, M.; Ridgill, M. P.; Yarnold, Christopher J.; Dawson, G.; Boyce, S.; Ellenbroek, A. A. Patent WO 2012\/110603, Aug 23, 2012."},{"key":"10.1016\/j.bmc.2016.02.014_h0145","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1381-1169(99)00400-8","volume":"156","author":"Magerlein","year":"2000","journal-title":"J. Mol. Catal. A"},{"key":"10.1016\/j.bmc.2016.02.014_h0150","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/cc0201086","volume":"5","author":"Georgsson","year":"2003","journal-title":"J. Comb. Chem."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616300967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616300967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T07:21:47Z","timestamp":1712474507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089616300967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0968089616300967"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2016.02.014","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2016.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}