{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:30:18Z","timestamp":1777566618547,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["BFP-0107-4.03\/12"],"award-info":[{"award-number":["BFP-0107-4.03\/12"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.bmc.2016.02.027","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T01:58:52Z","timestamp":1456192732000},"page":"1608-1618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Compound profiling and 3D-QSAR studies of hydrazone derivatives with activity against intracellular Trypanosoma cruzi"],"prefix":"10.1016","volume":"24","author":[{"given":"L\u00edvia Bandeira","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Ver\u00edssimo de Oliveira","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gevanio Bezerra","family":"de Oliveira Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Andr\u00e9 Teixeira","family":"de Moraes Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Wanderlan Pontes","family":"Esp\u00edndola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thays Gabrielle","family":"de Jesus Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Henrique Monteiro","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Junior","given":"Floriano Paes","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina C\u00e9lia Bressan Queiroz","family":"de Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina Lima","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2016.02.027_b0005","doi-asserted-by":"crossref","first-page":"e2367","DOI":"10.1371\/journal.pntd.0002367","volume":"7","author":"Diniz","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmc.2016.02.027_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/284729","volume":"2013","author":"Ayo","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bmc.2016.02.027_b0015","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1471-2334-13-85","volume":"13","author":"Jackson","year":"2013","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.bmc.2016.02.027_b0020","doi-asserted-by":"crossref","first-page":"e55497","DOI":"10.1371\/journal.pone.0055497","volume":"8","author":"Kessler","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2016.02.027_b0025","doi-asserted-by":"crossref","first-page":"e2370","DOI":"10.1371\/journal.pntd.0002370","volume":"7","author":"Wiggers","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmc.2016.02.027_b0030","doi-asserted-by":"crossref","first-page":"e675","DOI":"10.1371\/journal.pntd.0000675","volume":"4","author":"Siqueira-Neto","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmc.2016.02.027_b0035","doi-asserted-by":"crossref","first-page":"e384","DOI":"10.1371\/journal.pntd.0000384","volume":"3","author":"Bettiol","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmc.2016.02.027_b0040","doi-asserted-by":"crossref","first-page":"e26678","DOI":"10.1371\/journal.pone.0026678","volume":"6","author":"Alves","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2016.02.027_b0045","doi-asserted-by":"crossref","first-page":"e87188","DOI":"10.1371\/journal.pone.0087188","volume":"9","author":"Moon","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2016.02.027_b0050","doi-asserted-by":"crossref","first-page":"e2154","DOI":"10.1371\/journal.pntd.0002154","volume":"7","author":"Aulner","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmc.2016.02.027_b0055","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1017\/S003118201300142X","volume":"141","author":"Don","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.bmc.2016.02.027_b0060","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1087057114550585","volume":"20","author":"Chatelain","year":"2015","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.bmc.2016.02.027_b0065","doi-asserted-by":"crossref","first-page":"e740","DOI":"10.1371\/journal.pntd.0000740","volume":"4","author":"Canavaci","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmc.2016.02.027_b0070","doi-asserted-by":"crossref","first-page":"e1298","DOI":"10.1371\/journal.pntd.0001298","volume":"5","author":"Andriani","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bmc.2016.02.027_b0075","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.parint.2006.09.001","volume":"56","author":"Sereno","year":"2007","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.bmc.2016.02.027_b0080","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1074-5521(00)00018-1","volume":"7","author":"Du","year":"2000","journal-title":"Chem. Biol."},{"key":"10.1016\/j.bmc.2016.02.027_b0085","doi-asserted-by":"crossref","first-page":"6682","DOI":"10.1016\/j.bmc.2009.07.068","volume":"17","author":"dos Santos Filho","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.027_b0090","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bmc.2008.11.065","volume":"17","author":"Romeiro","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.027_b0095","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1016\/j.bmc.2012.08.047","volume":"20","author":"dos Santos Filho","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.027_b0100","doi-asserted-by":"crossref","first-page":"6366","DOI":"10.3390\/molecules18066366","volume":"18","author":"Franklim","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2016.02.027_b0105","doi-asserted-by":"crossref","first-page":"6404","DOI":"10.1021\/ja710254m","volume":"130","author":"Brak","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2016.02.027_b0110","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1021\/jm901633v","volume":"53","author":"Brak","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.027_b0115","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1021\/jm010459j","volume":"45","author":"Du","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.027_b0120","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1021\/jm030549j","volume":"47","author":"Greenbaum","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.027_b0125","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1016\/j.bmcl.2006.05.041","volume":"16","author":"Siles","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2016.02.027_b0130","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.ejmech.2015.06.048","volume":"101","author":"Esp\u00edndola","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.027_b0135","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejmech.2012.07.013","volume":"55","author":"Caputto","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.027_b0140","doi-asserted-by":"crossref","first-page":"10918","DOI":"10.1021\/jm301518v","volume":"55","author":"Moreira","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.027_b0145","doi-asserted-by":"crossref","first-page":"7826","DOI":"10.1016\/j.bmc.2010.09.056","volume":"18","author":"Hernandes","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.027_b0150","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/cmdc.200700022","volume":"2","author":"Leite","year":"2007","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2016.02.027_b0155","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejmech.2014.08.012","volume":"86","author":"Cardoso","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.027_b0160","doi-asserted-by":"crossref","first-page":"7478","DOI":"10.1016\/j.bmc.2015.10.048","volume":"23","author":"de Oliveira Filho","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.02.027_b0165","doi-asserted-by":"crossref","first-page":"8771","DOI":"10.1038\/srep08771","volume":"5","author":"Pe\u00f1a","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bmc.2016.02.027_b0170","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijantimicag.2012.09.018","volume":"41","author":"de B. Moreira","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bmc.2016.02.027_b0175","first-page":"495","volume":"25","author":"Sun","year":"2012","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.bmc.2016.02.027_b0180","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10822-006-9082-y","volume":"20","author":"Richmond","year":"2006","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.bmc.2016.02.027_b0185","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1128\/AAC.40.11.2592","volume":"40","author":"Buckner","year":"1996","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616301171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616301171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:38:54Z","timestamp":1760834334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089616301171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0968089616301171"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2016.02.027","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Compound profiling and 3D-QSAR studies of hydrazone derivatives with activity against intracellular Trypanosoma cruzi","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2016.02.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}