{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:54:06Z","timestamp":1782698046555,"version":"3.54.5"},"reference-count":23,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.bmc.2016.04.055","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T20:47:21Z","timestamp":1461790041000},"page":"2815-2822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["The 5-aromatic hydantoin-3-acetate derivatives as inhibitors of the tumour multidrug resistance efflux pump P-glycoprotein (ABCB1): Synthesis, crystallographic and biological studies"],"prefix":"10.1016","volume":"24","author":[{"given":"Ewa","family":"\u017bes\u0142awska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annam\u00e1ria","family":"Kincses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Spengler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Nitek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Wyrzuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kie\u0107-Kononowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadwiga","family":"Handzlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2016.04.055_b0005","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2174\/138945006777709593","volume":"7","author":"Nobili","year":"2006","journal-title":"Curr. Drugs Targets"},{"key":"10.1016\/j.bmc.2016.04.055_b0010","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1134\/S0006297908050118","volume":"73","author":"Stavrovskaya","year":"2008","journal-title":"Biochemistry (Moscow)"},{"key":"10.1016\/j.bmc.2016.04.055_b0015","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0014-827X(02)01229-6","volume":"57","author":"Teodori","year":"2002","journal-title":"Il Farmaco"},{"key":"10.1016\/j.bmc.2016.04.055_b0020","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1742-4658.2009.07485.x","volume":"277","author":"Ernst","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.bmc.2016.04.055_b0025","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.tips.2009.07.003","volume":"30","author":"Hall","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bmc.2016.04.055_b0030","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1475-2867-5-30","volume":"5","author":"Choi","year":"2005","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bmc.2016.04.055_b0035","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/qsar.200610149","volume":"26","author":"Zdrazil","year":"2007","journal-title":"QSAR Comb. Sci."},{"key":"10.1016\/j.bmc.2016.04.055_b0040","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1126\/science.1164440","volume":"332","author":"Weyand","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bmc.2016.04.055_b0045","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1107\/S0909049510032449","volume":"18","author":"Weyand","year":"2011","journal-title":"J. Synchrotron Rad."},{"key":"10.1016\/j.bmc.2016.04.055_b0050","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.bmc.2008.12.053","volume":"15","author":"Mudit","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.04.055_b0055","first-page":"4867","volume":"30","author":"Spengler","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bmc.2016.04.055_b0060","first-page":"3285","volume":"31","author":"Spengler","year":"2011","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bmc.2016.04.055_b0065","first-page":"293","volume":"26","author":"Martins","year":"2012","journal-title":"In Vivo"},{"key":"10.1016\/j.bmc.2016.04.055_b0070","first-page":"149","volume":"69","author":"Handzlik","year":"2012","journal-title":"Acta Polon. Pharm.-Drug Res."},{"key":"10.1016\/j.bmc.2016.04.055_b0075","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1016\/j.bmc.2012.02.009","volume":"20","author":"Handzlik","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.04.055_b0080","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1016\/j.ejmech.2011.09.032","volume":"46","author":"Handzlik","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.04.055_b0085","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.bmc.2010.11.051","volume":"19","author":"Handzlik","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.04.055_b0090","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/S0021-9258(18)61633-3","volume":"262","author":"Cornwell","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2016.04.055_b0095","first-page":"2173","volume":"29","author":"Spengler","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bmc.2016.04.055_b0100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1107\/S0021889898007717","volume":"32","author":"Altomare","year":"1999","journal-title":"Appl. Cryst."},{"key":"10.1016\/j.bmc.2016.04.055_b0105","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","volume":"A64","author":"Sheldrick","year":"2008","journal-title":"Acta Cryst."},{"key":"10.1016\/j.bmc.2016.04.055_b0110","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1107\/S0021889812029111","volume":"45","author":"Farrugia","year":"2012","journal-title":"J. Appl. Cryst."},{"key":"10.1016\/j.bmc.2016.04.055_b0115","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1107\/S002188980600731X","volume":"39","author":"Macrae","year":"2006","journal-title":"J. Appl. Cryst."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616303108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616303108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:42:18Z","timestamp":1760834538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089616303108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0968089616303108"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2016.04.055","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The 5-aromatic hydantoin-3-acetate derivatives as inhibitors of the tumour multidrug resistance efflux pump P-glycoprotein (ABCB1): Synthesis, crystallographic and biological studies","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2016.04.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}