{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:58:59Z","timestamp":1790114339726,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2012CB518000"],"award-info":[{"award-number":["2012CB518000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012470","name":"Doctoral Program Foundation of Institutions of Higher Education of China","doi-asserted-by":"publisher","award":["20120001110010"],"award-info":[{"award-number":["20120001110010"]}],"id":[{"id":"10.13039\/501100012470","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7162110"],"award-info":[{"award-number":["7162110"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371816"],"award-info":[{"award-number":["81371816"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21172012"],"award-info":[{"award-number":["21172012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.bmc.2016.05.055","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T18:26:09Z","timestamp":1464632769000},"page":"3472-3482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents"],"prefix":"10.1016","volume":"24","author":[{"given":"Jing","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengrong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2016.05.055_b0005","first-page":"1","volume":"2015","author":"Yan","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bmc.2016.05.055_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12985-014-0235-7","volume":"12","author":"Wang","year":"2015","journal-title":"Virol. J."},{"key":"10.1016\/j.bmc.2016.05.055_b0015","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/MOP.0000000000000246","volume":"26","author":"Nassef","year":"2015","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.bmc.2016.05.055_b0020","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1016\/j.vaccine.2014.08.064","volume":"32","author":"Liu","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.bmc.2016.05.055_b0025","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.7150\/ijbs.12996","volume":"11","author":"Yang","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bmc.2016.05.055_b0030","doi-asserted-by":"crossref","first-page":"16320","DOI":"10.3390\/molecules200916320","volume":"20","author":"Wang","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2016.05.055_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmii.2013.11.011","volume":"48","author":"Pourianfar","year":"2015","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.bmc.2016.05.055_b0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.antiviral.2011.05.009","volume":"92","author":"Pinto","year":"2011","journal-title":"Antivir. Res."},{"key":"10.1016\/j.bmc.2016.05.055_b0045","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1517\/13543776.18.6.603","volume":"18","author":"Price","year":"2008","journal-title":"Expert Opin. Ther. Patents"},{"key":"10.1016\/j.bmc.2016.05.055_b0050","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/35060098","volume":"3","author":"Pleschka","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bmc.2016.05.055_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-422X-11-1","volume":"11","author":"Shi","year":"2014","journal-title":"Virol. J."},{"key":"10.1016\/j.bmc.2016.05.055_b0060","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tips.2013.11.006","volume":"35","author":"Lou","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bmc.2016.05.055_b0065","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S1471-4914(02)00010-2","volume":"9","author":"Ludwig","year":"2003","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bmc.2016.05.055_b0070","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1021\/bi200542r","volume":"50","author":"Sheth","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2016.05.055_b0075","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.antiviral.2011.11.001","volume":"93","author":"Wang","year":"2012","journal-title":"Antivir. Res."},{"key":"10.1016\/j.bmc.2016.05.055_b0080","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.antiviral.2014.03.009","volume":"106","author":"Gao","year":"2014","journal-title":"Antivir. Res."},{"key":"10.1016\/j.bmc.2016.05.055_b0085","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.1016\/j.bmcl.2005.08.097","volume":"15","author":"Han","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2016.05.055_b0090","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0278-6915(99)00010-1","volume":"37","author":"Lake","year":"1999","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bmc.2016.05.055_b0095","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.bmcl.2011.01.071","volume":"21","author":"Dong","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2016.05.055_b0100","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1021\/ja01568a039","volume":"79","author":"Shaprio","year":"1957","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2016.05.055_b0105","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1021\/ja100783c","volume":"132","author":"Zhao","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2016.05.055_b0110","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ejmech.2014.04.025","volume":"79","author":"Liu","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.05.055_b0115","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/op0600106","volume":"10","author":"Borghese","year":"2006","journal-title":"Org. Process Res. Dev."},{"key":"10.1016\/j.bmc.2016.05.055_b0120","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1080\/00397911.2011.573169","volume":"42","author":"Chen","year":"2012","journal-title":"Synth. Commun."},{"key":"10.1016\/j.bmc.2016.05.055_b0125","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.1021\/jm0704548","volume":"50","author":"Spicer","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.05.055_b0130","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bbrc.2011.11.145","volume":"417","author":"Roskoski","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmc.2016.05.055_b0135","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ccr.2014.03.011","volume":"25","author":"Lito","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bmc.2016.05.055_b0140","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/onc.2012.160","volume":"32","author":"Little","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.bmc.2016.05.055_b0145","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.18632\/oncotarget.747","volume":"3","author":"Yoshida","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.bmc.2016.05.055_b0150","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/cmdc.201402484","volume":"10","author":"Sun","year":"2015","journal-title":"ChemMedChem"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616303881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616303881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:44:34Z","timestamp":1760834674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089616303881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":30,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0968089616303881"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2016.05.055","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2016.05.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}