{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:11:29Z","timestamp":1779927089899,"version":"3.53.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.bmc.2016.06.047","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T18:19:20Z","timestamp":1466878760000},"page":"4038-4044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Synthesis and potent antiprotozoal activity of mono\/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense"],"prefix":"10.1016","volume":"24","author":[{"given":"Cigdem","family":"Karaaslan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Brun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"G\u00f6ker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2016.06.047_b0005","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1172\/JCI33945","volume":"118","author":"Stuart","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bmc.2016.06.047_b0010","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/inthealth\/ihu037","volume":"6","author":"Molyneux","year":"2014","journal-title":"Int. Health"},{"key":"10.1016\/j.bmc.2016.06.047_b0015","unstructured":"WHO website http:\/\/www.who.int\/mediacentre\/factsheets\/fs094\/en\/, 2016."},{"key":"10.1016\/j.bmc.2016.06.047_b0020","unstructured":"WHO website http:\/\/www.who.int\/malaria\/media\/world-malaria-report-2015\/en\/, 2015."},{"key":"10.1016\/j.bmc.2016.06.047_b0025","unstructured":"WHO website http:\/\/www.who.int\/mediacentre\/factsheets\/fs259\/en\/, 2015."},{"key":"10.1016\/j.bmc.2016.06.047_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/389153","volume":"2010","author":"Baral","year":"2010","journal-title":"Biomed. Biotechnol."},{"key":"10.1016\/j.bmc.2016.06.047_b0035","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1517\/13543784.14.8.957","volume":"14","author":"Soeiro","year":"2005","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.bmc.2016.06.047_b0040","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1016\/j.bmc.2005.07.024","volume":"13","author":"Ismail","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.06.047_b0045","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1590\/S0103-50532002000600006","volume":"13","author":"Boykin","year":"2002","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.bmc.2016.06.047_b0050","doi-asserted-by":"crossref","first-page":"13659","DOI":"10.1021\/ja048175m","volume":"126","author":"Mallena","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2016.06.047_b0055","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1128\/AAC.05122-14","volume":"59","author":"Rice","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2016.06.047_b0060","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.ejmech.2008.10.003","volume":"44","author":"Alp","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.06.047_b0065","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1021\/cr60210a003","volume":"61","author":"Roger","year":"1961","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bmc.2016.06.047_b0070","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1021\/jm00064a008","volume":"36","author":"Fairley","year":"1993","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.06.047_b0075","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1016\/j.tetlet.2006.03.112","volume":"47","author":"Cee","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2016.06.047_b0080","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.ejmech.2007.10.009","volume":"43","author":"Ozden","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.06.047_b0085","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1128\/AAC.18.2.231","volume":"18","author":"Anne","year":"1980","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2016.06.047_b0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00172069","volume":"1","author":"Balzarini","year":"1983","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.bmc.2016.06.047_b0095","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/chem.201503618","volume":"22","author":"Bharatam","year":"2016","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.bmc.2016.06.047_b0100","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1016\/j.phytochem.2006.05.039","volume":"67","author":"Ganapaty","year":"2006","journal-title":"Phytochemistry"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616304709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616304709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:47:33Z","timestamp":1760834853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089616304709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":20,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0968089616304709"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2016.06.047","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and potent antiprotozoal activity of mono\/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2016.06.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}