{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:45:14Z","timestamp":1790437514700,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006181","name":"FAPESB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.bmc.2016.09.013","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T11:18:30Z","timestamp":1473765510000},"page":"5693-5701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Conjugation of N-acylhydrazone and 1,2,4-oxadiazole leads to the identification of active antimalarial agents"],"prefix":"10.1016","volume":"24","author":[{"given":"Jos\u00e9 Maur\u00edcio","family":"dos Santos Filho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Manoel Alves","family":"de Queiroz e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u00eds Soares","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Mariana Pitangueira","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Rodrigo Magalhaes","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soura","family":"Challal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Wolfender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson Ferreira","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Botelho Pereira","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2016.09.013_b0005","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/S0140-6736(13)60310-4","volume":"382","author":"Cotter","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2016.09.013_b0010","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1128\/AAC.04632-14","volume":"59","author":"Mishra","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2016.09.013_b0015","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S1473-3099(14)70855-2","volume":"14","author":"Price","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.bmc.2016.09.013_b0020","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/QCO.0b013e32834c630e","volume":"24","author":"Jacobs","year":"2011","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.bmc.2016.09.013_b0025","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1093\/infdis\/jis184","volume":"205","author":"Da Cruz","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bmc.2016.09.013_b0030","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1021\/jm400004u","volume":"56","author":"Wang","year":"2013","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.09.013_b0035","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa1315860","volume":"371","author":"White","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bmc.2016.09.013_b0040","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1128\/AAC.00040-14","volume":"58","author":"Wein","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2016.09.013_b0045","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.bmcl.2013.11.002","volume":"24","author":"Stokes","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2016.09.013_b0050","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1021\/jm500066b","volume":"57","author":"Rackham","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.09.013_b0055","doi-asserted-by":"crossref","unstructured":"Soeiro, M. N.; de Souza, E. M.; da Silva, C. F.; Batista, D. G.; Batista, M. M.; Pav\u00e3o, B. P.; Ara\u00fajo, J. S.; Aiub, C. A.; da Silva, P. B.; Lionel, J.; Britto, C.; Kim, K.; Sulikowski, G.; Hargrove, T. Y.; Waterman, M. R.; Lepesheva, G. I. Antimicrob. Agents Chemother. 2013, 57, 4151.","DOI":"10.1128\/AAC.00070-13"},{"key":"10.1016\/j.bmc.2016.09.013_b0060","doi-asserted-by":"crossref","first-page":"e35033","DOI":"10.1371\/journal.pone.0035033","volume":"7","author":"Ross","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2016.09.013_b0065","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1093\/infdis\/jiv228","volume":"212","author":"Lepesheva","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bmc.2016.09.013_b0070","doi-asserted-by":"crossref","first-page":"6682","DOI":"10.1016\/j.bmc.2009.07.068","volume":"17","author":"dos Santos Filho","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.09.013_b0075","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1016\/j.bmc.2012.08.047","volume":"20","author":"dos Santos Filho","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2016.09.013_b0080","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/cmdc.201100441","volume":"7","author":"Mombelli","year":"2012","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2016.09.013_b0085","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejmech.2014.01.023","volume":"75","author":"Inam","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.09.013_b0090","first-page":"266","volume":"4","author":"Kumar","year":"2012","journal-title":"Int. J. PharmTech Res."},{"key":"10.1016\/j.bmc.2016.09.013_h0095","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/cmdc.201300459","volume":"9","author":"Gomes","year":"2014","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2016.09.013_h0100","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.bmcl.2012.12.032","volume":"23","author":"P\u00e9rez","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2016.09.013_h0105","doi-asserted-by":"crossref","first-page":"7690","DOI":"10.1002\/anie.201303690","volume":"52","author":"Dubar","year":"2013","journal-title":"Angew. Chem., Int. Ed."},{"key":"10.1016\/j.bmc.2016.09.013_h0110","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1021\/jm970401y","volume":"40","author":"Biot","year":"1997","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.09.013_b0105","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.1002\/ejoc.201402609","volume":"29","author":"dos Santos Filho","year":"2014","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.bmc.2016.09.013_b0110","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1039\/B816249B","volume":"6","author":"Spencer","year":"2009","journal-title":"Dalton Trans."},{"key":"10.1016\/j.bmc.2016.09.013_b0115","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1590\/S0103-50532008000700003","volume":"19","author":"Silva","year":"2008","journal-title":"J. Braz. Chem. Soc."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616307003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616307003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:43:08Z","timestamp":1760834588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089616307003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":25,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0968089616307003"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2016.09.013","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conjugation of N-acylhydrazone and 1,2,4-oxadiazole leads to the identification of active antimalarial agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2016.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}