{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:26:53Z","timestamp":1787063213583,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.bmc.2016.09.074","type":"journal-article","created":{"date-parts":[[2016,10,8]],"date-time":"2016-10-08T20:04:38Z","timestamp":1475957078000},"page":"6183-6193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis of N-aryl and N-arylcarbamoylamino derivatives of 1,3-diazinane-5-carboxamide and their activity against glioblastoma LN-229 cell line"],"prefix":"10.1016","volume":"24","author":[{"given":"Rebecca J.","family":"Hron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branko S.","family":"Jursic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2016.09.074_b0005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mrfmmm.2012.07.005","volume":"738","author":"Pastor","year":"2012","journal-title":"Mutat. Res. Fund. Mol. Mech."},{"key":"10.1016\/j.bmc.2016.09.074_b0010","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/bmb.20244","volume":"37","author":"Deweese","year":"2009","journal-title":"Biochem. Mol. Biol. Educ."},{"key":"10.1016\/j.bmc.2016.09.074_b0015","doi-asserted-by":"crossref","first-page":"17643","DOI":"10.1074\/jbc.273.28.17643","volume":"273","author":"Fortune","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bmc.2016.09.074_b0020","first-page":"1021","volume":"8","author":"Ukita","year":"1960","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bmc.2016.09.074_b0025","unstructured":"Brewer, A. D.; Minatelli, J. A. US Patent, 4,634,707, 1987."},{"key":"10.1016\/j.bmc.2016.09.074_b0030","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1021\/acsmedchemlett.5b00040","volume":"6","author":"Baviskar","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2016.09.074_b0035","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1208\/s12248-009-9144-x","volume":"11","author":"Dahan","year":"2009","journal-title":"AAPS J."},{"key":"10.1016\/j.bmc.2016.09.074_b0040","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrd3701","volume":"11","author":"Hann","year":"2012","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.bmc.2016.09.074_b0045","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1161\/CIRCGENETICS.115.001219","volume":"8","author":"Burnet","year":"2015","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.bmc.2016.09.074_b0050","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1039\/c2cc30351e","author":"Peng","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bmc.2016.09.074_b0055","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1021\/je60041a042","volume":"14","author":"Mack","year":"1969","journal-title":"J. Chem. Eng. Data"},{"key":"10.1016\/j.bmc.2016.09.074_b0060","series-title":"Greene\u2019s Protective Groups in Organic Synthesis","author":"Wuts","year":"2007"},{"key":"10.1016\/j.bmc.2016.09.074_b0065","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1021\/jm501371s","volume":"58","author":"Ghosh","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.09.074_b0070","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1021\/jf00077a044","volume":"35","author":"Wu","year":"1987","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bmc.2016.09.074_b0075","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1584\/jpestics.9.489","volume":"9","author":"Kato","year":"1984","journal-title":"Pestic. Sci."},{"key":"10.1016\/j.bmc.2016.09.074_b0080","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1016\/0040-4039(96)01248-8","volume":"37","author":"Knolker","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2016.09.074_b0085","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1021\/ol7024108","volume":"9","author":"Shimizu","year":"2007","journal-title":"Org. Lett."},{"key":"10.1016\/j.bmc.2016.09.074_b0090","unstructured":"Warrell, R. P.; Piwinski, J. J. Intl. Patent WO 2015\/123003 A1."},{"key":"10.1016\/j.bmc.2016.09.074_b0095","unstructured":"Hardwick, F.; Cotton, A.; Field, P. G. S. Intl. Patent WO 84\/01380."},{"key":"10.1016\/j.bmc.2016.09.074_b0100","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0040-4039(02)00094-1","volume":"43","author":"Uriz","year":"2002","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2016.09.074_b0105","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s10965-016-1052-z","volume":"23","author":"Yang","year":"2016","journal-title":"J. Polym. Res."},{"key":"10.1016\/j.bmc.2016.09.074_b0110","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1021\/ja312532x","volume":"135","author":"Laursen","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bmc.2016.09.074_b0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ana.22425","volume":"70","author":"Preusser","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bmc.2016.09.074_b0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/cncr.22741","volume":"110","author":"Sathornsumetee","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.bmc.2016.09.074_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2015.02.002","volume":"19","author":"van Tellingen","year":"2015","journal-title":"Drug Resist. Update"},{"key":"10.1016\/j.bmc.2016.09.074_b0130","doi-asserted-by":"crossref","first-page":"e108166","DOI":"10.1371\/journal.pone.0108166","volume":"9","author":"Lee","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2016.09.074_b0135","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1602\/neurorx.2.4.541","volume":"2","author":"Pajouhesh","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.bmc.2016.09.074_b0140","doi-asserted-by":"crossref","first-page":"7559","DOI":"10.1021\/jm060642i","volume":"49","author":"Hitchcock","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2016.09.074_b0145","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1016\/j.tetlet.2010.09.044","volume":"51","author":"Todorovic","year":"2010","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bmc.2016.09.074_b0150","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1016\/j.bmcl.2007.07.068","volume":"18","author":"Harriman","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2016.09.074_b0155","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1021\/ci00063a006","volume":"29","author":"Viswanadhan","year":"1989","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.bmc.2016.09.074_b0160","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s13277-015-3781-8","volume":"37","author":"Kusaczuk","year":"2016","journal-title":"Tumor Biol."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616308604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616308604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:42:40Z","timestamp":1760834560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089616308604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":32,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0968089616308604"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2016.09.074","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of N-aryl and N-arylcarbamoylamino derivatives of 1,3-diazinane-5-carboxamide and their activity against glioblastoma LN-229 cell line","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2016.09.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}