{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T22:43:39Z","timestamp":1781563419444,"version":"3.54.5"},"reference-count":61,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T00:00:00Z","timestamp":1517270400000},"content-version":"am","delay-in-days":363,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"National Institutes of Health, Department of Health and Human Services","doi-asserted-by":"publisher","award":["HHSN272200700057C"],"award-info":[{"award-number":["HHSN272200700057C"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"National Institutes of Health, Department of Health and Human Services","doi-asserted-by":"publisher","award":["HHSN272201200025C"],"award-info":[{"award-number":["HHSN272201200025C"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institutes of Health, National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006151","name":"Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100006151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["C06 RR029870"],"award-info":[{"award-number":["C06 RR029870"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K22 AI089786"],"award-info":[{"award-number":["K22 AI089786"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.bmc.2016.11.013","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T05:00:54Z","timestamp":1478754054000},"page":"813-824","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents"],"prefix":"10.1016","volume":"25","author":[{"given":"Travis R.","family":"Helgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phumvadee","family":"Wangtrakuldee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart L.","family":"Staker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Abendroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banumathi","family":"Sankaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole A.","family":"Housley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Myler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon P.","family":"Audia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Hagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2016.11.013_b0005","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1086\/523649","volume":"197","author":"Bechah","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bmc.2016.11.013_b0010","series-title":"Intracellular Pathogens II: Rickettsiales","article-title":"Rickettsial physiology and metabolism in the face of reductive evolution","author":"Audia","year":"2012"},{"key":"10.1016\/j.bmc.2016.11.013_h0015","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0923-2508(00)00116-9","volume":"151","author":"Andersson","year":"2000","journal-title":"Res Microbiol"},{"key":"10.1016\/j.bmc.2016.11.013_h0020","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0891-5520(03)00093-X","volume":"18","author":"Raoult","year":"2004","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.bmc.2016.11.013_b0020","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1128\/JCM.43.9.4708-4712.2005","volume":"43","author":"Zhu","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmc.2016.11.013_b0025","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1128\/JCM.37.11.3722-3724.1999","volume":"37","author":"Birg","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmc.2016.11.013_b0030","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1749-6632.2003.tb07453.x","volume":"990","author":"Walker","year":"2003","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.bmc.2016.11.013_b0035","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1086\/518145","volume":"45","author":"Walker","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bmc.2016.11.013_b0040","doi-asserted-by":"crossref","first-page":"D52","DOI":"10.1016\/j.vaccine.2009.07.045","volume":"27","author":"Walker","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.bmc.2016.11.013_b0045","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1128\/jb.83.2.409-414.1962","volume":"83","author":"Weiss","year":"1962","journal-title":"J Bacteriol"},{"key":"10.1016\/j.bmc.2016.11.013_b0050","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1128\/jb.171.7.4071-4072.1989","volume":"171","author":"Chang","year":"1989","journal-title":"J Bacteriol"},{"key":"10.1016\/j.bmc.2016.11.013_b0055","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1021\/ml400034m","volume":"4","author":"Wangtrakuldee","year":"2013","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmc.2016.11.013_b0060","doi-asserted-by":"crossref","first-page":"13940","DOI":"10.1021\/ja045864p","volume":"126","author":"Ye","year":"2004","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2016.11.013_b0065","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1021\/jm501790e","volume":"58","author":"Arya","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2016.11.013_b0070","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.jinorgbio.2008.05.006","volume":"102","author":"Zheng","year":"2008","journal-title":"J Inorg Biochem"},{"key":"10.1016\/j.bmc.2016.11.013_b0075","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nprot.2013.172","volume":"9","author":"Zheng","year":"2014","journal-title":"Nat Protoc"},{"key":"10.1016\/j.bmc.2016.11.013_b0080","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2174\/1568026615666150813145410","volume":"16","author":"Helgren","year":"2016","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmc.2016.11.013_h0090","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/jm901137j","volume":"53","author":"Baell","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2016.11.013_h0095","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1021\/acs.jnatprod.5b00947","volume":"79","author":"Baell","year":"2016","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2016.11.013_h0100","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/513481a","volume":"513","author":"Baell","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2016.11.013_b0090","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1016\/j.bmcl.2010.03.067","volume":"20","author":"Lu","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2016.11.013_b0095","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1021\/jm901624n","volume":"53","author":"Lu","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2016.11.013_h0115","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.bmcl.2010.02.052","volume":"20","author":"Chai","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2016.11.013_h0120","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1016\/j.bmcl.2005.09.019","volume":"15","author":"Huang","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2016.11.013_h0125","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/cmdc.201200076","volume":"7","author":"Huguet","year":"2012","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2016.11.013_h0130","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1021\/cc700085c","volume":"10","author":"Vedantham","year":"2008","journal-title":"J Comb Chem"},{"key":"10.1016\/j.bmc.2016.11.013_h0135","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1107\/S0907444906003878","volume":"62","author":"Xie","year":"2006","journal-title":"Acta Crystallogr Sect D"},{"key":"10.1016\/j.bmc.2016.11.013_h0140","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1021\/jm700930k","volume":"50","author":"Huang","year":"2007","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2016.11.013_h0145","doi-asserted-by":"crossref","first-page":"26879","DOI":"10.1074\/jbc.M804345200","volume":"283","author":"Chai","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2016.11.013_b0105","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1016\/j.bmcl.2011.03.116","volume":"21","author":"Yuan","year":"2011","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2016.11.013_h0155","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00775-009-0471-2","volume":"14","author":"Mitra","year":"2009","journal-title":"J Biol Inorg Chem"},{"key":"10.1016\/j.bmc.2016.11.013_h0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-2836(03)00862-3","volume":"332","author":"Oefner","year":"2003","journal-title":"J Mol Biol"},{"key":"10.1016\/j.bmc.2016.11.013_b0115","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1021\/jm061182w","volume":"50","author":"Marino","year":"2007","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2016.11.013_b0120","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1016\/j.tube.2011.10.012","volume":"91","author":"Olaleye","year":"2011","journal-title":"Tuberculosis"},{"key":"10.1016\/j.bmc.2016.11.013_h0175","doi-asserted-by":"crossref","first-page":"6862","DOI":"10.1016\/j.bmcl.2009.10.082","volume":"19","author":"Chai","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2016.11.013_h0180","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.bbrc.2005.11.042","volume":"339","author":"Huang","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmc.2016.11.013_h0185","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1016\/j.bmcl.2010.05.093","volume":"20","author":"Altmeyer","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2016.11.013_b0130","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Morris","year":"2009","journal-title":"J Comput Chem"},{"key":"10.1016\/j.bmc.2016.11.013_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6807-7-84","volume":"7","author":"Ma","year":"2007","journal-title":"BMC Struct Biol"},{"key":"10.1016\/j.bmc.2016.11.013_b0140","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1039\/c2ob06978d","volume":"10","author":"Bhat","year":"2012","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2016.11.013_b0145","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1021\/bi020670c","volume":"42","author":"Wang","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2016.11.013_h0210","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1248\/bpb.27.772","volume":"27","author":"Sato","year":"2004","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.bmc.2016.11.013_h0215","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nbt1415","volume":"26","author":"Benny","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bmc.2016.11.013_b0155","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/cmdc.201200585","volume":"8","author":"Ballatore","year":"2013","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2016.11.013_b0160","volume":"Vol. 276","author":"Otwinowski","year":"1997"},{"key":"10.1016\/j.bmc.2016.11.013_h0230","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","volume":"40","author":"McCoy","year":"2007","journal-title":"J Appl Crystallogr"},{"key":"10.1016\/j.bmc.2016.11.013_h0235","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1107\/S0907444910045749","volume":"67","author":"Winn","year":"2011","journal-title":"Acta Crystallogr Sect D"},{"key":"10.1016\/j.bmc.2016.11.013_h0240","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1107\/S0907444904023510","volume":"60","author":"Vagin","year":"2004","journal-title":"Acta Crystallogr Sect D"},{"key":"10.1016\/j.bmc.2016.11.013_h0245","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr Sect D"},{"key":"10.1016\/j.bmc.2016.11.013_b0175","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr Sect D"},{"key":"10.1016\/j.bmc.2016.11.013_h0255","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2174\/187152609789105687","volume":"9","author":"Myler","year":"2009","journal-title":"Infect Disord Drug Targets"},{"key":"10.1016\/j.bmc.2016.11.013_h0260","first-page":"979","volume":"67","author":"Stacy","year":"2011","journal-title":"Acta Crystallogr Sect D"},{"key":"10.1016\/j.bmc.2016.11.013_h0265","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1107\/S2053230X15004677","volume":"71","author":"Serbzhinskiy","year":"2015","journal-title":"Acta Crystallogr Sect F"},{"key":"10.1016\/j.bmc.2016.11.013_h0270","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1107\/S1744309111018367","volume":"67","author":"Bryan","year":"2011","journal-title":"Acta Crystallogr Sect F"},{"key":"10.1016\/j.bmc.2016.11.013_h0275","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1107\/S1744309111017374","volume":"67","author":"Choi","year":"2011","journal-title":"Acta Crystallogr Sect F"},{"key":"10.1016\/j.bmc.2016.11.013_b0185","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1093\/nar\/18.20.6069","volume":"18","author":"Aslanidis","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bmc.2016.11.013_b0190","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1177\/1087057102238627","volume":"7","author":"Grant","year":"2002","journal-title":"J Biomol Screen"},{"key":"10.1016\/j.bmc.2016.11.013_b0195","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1084\/jem.89.6.561","volume":"89","author":"Bovarnick","year":"1949","journal-title":"J Exp Med"},{"key":"10.1016\/j.bmc.2016.11.013_b0200","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1128\/iai.9.1.119-126.1974","volume":"9","author":"Winkler","year":"1974","journal-title":"Infect Immun"},{"key":"10.1016\/j.bmc.2016.11.013_b0205","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1128\/jcm.9.5.645-647.1979","volume":"9","author":"Walker","year":"1979","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmc.2016.11.013_b0210","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.mvr.2003.11.006","volume":"67","author":"King","year":"2004","journal-title":"Microvasc Res"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616311580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616311580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:48:15Z","timestamp":1760834895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089616311580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0968089616311580"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2016.11.013","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2016.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}