{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:21:58Z","timestamp":1791570118055,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"R&D team program of Guangdong Province","award":["2009010048"],"award-info":[{"award-number":["2009010048"]}]},{"name":"National Science and Technology Major Project of China","award":["2013ZX09101003"],"award-info":[{"award-number":["2013ZX09101003"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.bmc.2016.12.017","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T02:01:45Z","timestamp":1482112905000},"page":"1042-1056","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4)"],"prefix":"10.1016","volume":"25","author":[{"given":"Qingyun","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaolei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Goldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2016.12.017_b0005","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra031087","volume":"350","author":"Ganem","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bmc.2016.12.017_b0010","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/epirev\/mxj009","volume":"28","author":"Shepard","year":"2006","journal-title":"Epidemiol Rev"},{"key":"10.1016\/j.bmc.2016.12.017_b0015","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/hep.22956","volume":"49","author":"Perrillo","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.bmc.2016.12.017_b0020","first-page":"714","volume":"24","author":"Tipples","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.bmc.2016.12.017_b0025","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1473-3099(07)70264-5","volume":"8","author":"Papatheodoridis","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bmc.2016.12.017_b0030","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nbt1389","volume":"26","author":"Petersen","year":"2008","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.bmc.2016.12.017_b0035","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.tibtech.2003.09.012","volume":"21","author":"Zlotnick","year":"2003","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.bmc.2016.12.017_b0040","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1128\/JVI.74.19.9099-9105.2000","volume":"74","author":"Le Pogam","year":"2000","journal-title":"J Virol"},{"key":"10.1016\/j.bmc.2016.12.017_b0045","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0065-3527(05)64005-5","volume":"64","author":"Steven","year":"2005","journal-title":"Adv Virus Res"},{"key":"10.1016\/j.bmc.2016.12.017_b0050","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2180-5-33","volume":"5","author":"Chain","year":"2005","journal-title":"BMC Microb"},{"key":"10.1016\/j.bmc.2016.12.017_b0055","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2174\/187152607782110077","volume":"7","author":"Choi","year":"2007","journal-title":"Infect. Disorders Drug Targets"},{"key":"10.1016\/j.bmc.2016.12.017_b0060","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1128\/AAC.46.9.3057-3060.2002","volume":"46","author":"Delaney","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2016.12.017_b0065","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.antiviral.2007.06.014","volume":"76","author":"Feld","year":"2007","journal-title":"Antiviral Res"},{"key":"10.1016\/j.bmc.2016.12.017_b0070","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1053\/jhep.2001.25103","volume":"33","author":"Mehta","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.bmc.2016.12.017_b0075","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1128\/AAC.46.12.4004-4008.2002","volume":"46","author":"Mehta","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2016.12.017_b0080","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1128\/JVI.76.10.4848-4854.2002","volume":"76","author":"Zlotnick","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.bmc.2016.12.017_b0085","doi-asserted-by":"crossref","first-page":"11933","DOI":"10.1128\/JVI.77.22.11933-11940.2003","volume":"77","author":"Lu","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.bmc.2016.12.017_b0090","doi-asserted-by":"crossref","first-page":"5660","DOI":"10.1021\/jm200696v","volume":"54","author":"Yu","year":"2011","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.017_b0095","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1128\/AAC.00541-07","volume":"51","author":"Dougherty","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2016.12.017_b0100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0166-3542(01)00216-9","volume":"54","author":"Weber","year":"2002","journal-title":"Antiviral Res"},{"key":"10.1016\/j.bmc.2016.12.017_b0105","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/jmr.801","volume":"19","author":"Stray","year":"2006","journal-title":"J Mol Recognit"},{"key":"10.1016\/j.bmc.2016.12.017_b0110","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.toxlet.2007.07.010","volume":"173","author":"Shi","year":"2007","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.bmc.2016.12.017_b0115","doi-asserted-by":"crossref","first-page":"11055","DOI":"10.1128\/JVI.00933-06","volume":"80","author":"Bourne","year":"2006","journal-title":"J Virol"},{"key":"10.1016\/j.bmc.2016.12.017_b0120","doi-asserted-by":"crossref","first-page":"15196","DOI":"10.1073\/pnas.1513803112","volume":"112","author":"Klumpp","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2016.12.017_b0125","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.1077215","volume":"299","author":"Deres","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bmc.2016.12.017_b0130","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1128\/AAC.01091-13","volume":"11","author":"Wu","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2016.12.017_b0135","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/rcm.1327","volume":"18","author":"Hsieh","year":"2004","journal-title":"Rapid Commun Mass Spectrom"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616312019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616312019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:49:17Z","timestamp":1760834957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089616312019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0968089616312019"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2016.12.017","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4)","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2016.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}