{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:05:45Z","timestamp":1792515945775,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Council of Scientific and Industrial Research"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.bmc.2016.12.047","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T02:51:34Z","timestamp":1482979894000},"page":"1286-1293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors"],"prefix":"10.1016","volume":"25","author":[{"given":"Rajiv","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sita","family":"Ram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Del Prete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemente","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2016.12.047_h0005","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2016.12.047_h0010","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2016.12.047_h0015","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/14756366.2014.910202","volume":"30","author":"Capasso","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0020","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2016.12.047_h0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med Res Rev"},{"key":"10.1016\/j.bmc.2016.12.047_h0030","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1016\/j.bmcl.2014.08.015","volume":"24","author":"Del Prete","year":"2014","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2016.12.047_h0035","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1021\/jm9901879","volume":"42","author":"Scozzafava","year":"1999","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0040","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0223-5234(99)80039-7","volume":"34","author":"Supuran","year":"1999","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0045","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/14756366.2015.1122001","volume":"31","author":"Supuran","year":"2016","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0050","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1042\/BCJ20160115","volume":"473","author":"Supuran","year":"2016","journal-title":"Biochem J"},{"key":"10.1016\/j.bmc.2016.12.047_h0055","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","volume":"27","author":"Supuran","year":"2012","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0060","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1586\/14737175.2015.1066675","volume":"15","author":"Supuran","year":"2015","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.bmc.2016.12.047_h0065","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1021\/jm000296j","volume":"43","author":"Scozzafava","year":"2000","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0070","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0223-5234(98)80042-1","volume":"33","author":"Supuran","year":"1998","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0020","doi-asserted-by":"crossref","first-page":"9828","DOI":"10.1073\/pnas.1603112113","volume":"113","author":"Kikutani","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2016.12.047_h0080","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bbapap.2009.07.027","volume":"1804","author":"De Simone","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmc.2016.12.047_h0085","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1021\/jm050333c","volume":"48","author":"Menchise","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0090","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/14756366.2013.761876","volume":"28","author":"Supuran","year":"2013","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0095","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3109\/14756366.2013.787422","volume":"29","author":"Capasso","year":"2014","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0100","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/S0968-0896(99)00190-X","volume":"7","author":"Borras","year":"1999","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0105","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.bmc.2010.01.076","volume":"18","author":"Innocenti","year":"2010","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0110","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/14756366.2011.643303","volume":"28","author":"Ekinci","year":"2013","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0115","doi-asserted-by":"crossref","first-page":"9101","DOI":"10.1016\/j.bmc.2008.09.028","volume":"16","author":"Bayram","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0120","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2174\/156802607780636690","volume":"7","author":"Supuran","year":"2007","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0125","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1517\/13543776.2012.698264","volume":"22","author":"Carta","year":"2012","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2016.12.047_h0130","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1517\/13543776.2013.778246","volume":"23","author":"Supuran","year":"2013","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2016.12.047_h0135","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3109\/14756366.2014.892936","volume":"30","author":"Akdemir","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0140","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.bmcl.2004.12.052","volume":"15","author":"Vullo","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2016.12.047_h0145","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/14756360410001689540","volume":"19","author":"Pastorekova","year":"2004","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0150","first-page":"49","volume":"2","author":"Supuran","year":"2004","journal-title":"Curr Med Chem Cardiovasc Hematol Agents"},{"key":"10.1016\/j.bmc.2016.12.047_h0155","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1021\/jm0108202","volume":"45","author":"Scozzafava","year":"2002","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0160","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1021\/jm050483n","volume":"48","author":"Nishimori","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0045","series-title":"Carbonic Anhydrase\u2014Its Inhibitors and Activators","first-page":"1","year":"2004"},{"key":"10.1016\/j.bmc.2016.12.047_b0050","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ejmech.2014.12.012","volume":"90","author":"Fascio","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0055","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/j.bmcl.2012.01.052","volume":"22","author":"Alegaon","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2016.12.047_b0060","doi-asserted-by":"crossref","first-page":"22069","DOI":"10.3390\/molecules201219827","volume":"20","author":"El-Hashash","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2016.12.047_b0065","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.ejmech.2015.03.021","volume":"95","author":"Alwan","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0070","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.ejmech.2007.06.023","volume":"43","author":"Jadhav","year":"2008","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0075","first-page":"550","volume":"50","author":"Andreani","year":"2000","journal-title":"Arzneim Forsch Drug Res"},{"key":"10.1016\/j.bmc.2016.12.047_b0080","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.ejmech.2006.12.006","volume":"42","author":"Leysak","year":"2007","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0085","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0223-5234(03)00138-7","volume":"38","author":"Terzioglu","year":"2003","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0090","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1016\/j.ejmech.2009.01.003","volume":"44","author":"Ibrahim","year":"2009","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0095","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1248\/cpb.c15-00379","volume":"63","author":"Barbuceanu","year":"2015","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.bmc.2016.12.047_b0100","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1016\/j.bmc.2015.03.049","volume":"23","author":"Kazkayasi","year":"2015","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0105","first-page":"35","volume":"54","author":"Tozkoparan","year":"2004","journal-title":"Arzneim Forsch Drug Res"},{"key":"10.1016\/j.bmc.2016.12.047_b0110","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0223-5234(91)90135-A","volume":"26","author":"Pignatello","year":"1991","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0115","first-page":"707","volume":"48","author":"Demirayak","year":"1993","journal-title":"I l Farmaco"},{"key":"10.1016\/j.bmc.2016.12.047_b0120","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.ejmech.2011.02.064","volume":"46","author":"Karki","year":"2011","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0125","doi-asserted-by":"crossref","first-page":"6713","DOI":"10.1021\/ja01629a133","volume":"77","author":"Oleson","year":"1955","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2016.12.047_b0130","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1007\/s00044-011-9853-4","volume":"21","author":"Kumar","year":"2012","journal-title":"Med Chem Res"},{"key":"10.1016\/j.bmc.2016.12.047_h0255","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ejmech.2014.02.023","volume":"76","author":"Khloya","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0260","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/1475636021000006261","volume":"17","author":"Chohan","year":"2002","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0140","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.bmc.2014.01.055","volume":"22","author":"Ram","year":"2014","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0270","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1016\/j.bmc.2014.10.018","volume":"22","author":"Ram","year":"2014","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_h0275","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/med.20068","volume":"26","author":"Winum","year":"2006","journal-title":"Med Res Rev"},{"key":"10.1016\/j.bmc.2016.12.047_b0150","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1016\/j.bmcl.2015.05.096","volume":"25","author":"Khloya","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2016.12.047_b0155","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/j.bmc.2016.04.061","volume":"24","author":"Kumar","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0160","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1016\/j.bmc.2016.04.052","volume":"24","author":"Chandak","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2016.12.047_b0165","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.2042-7158.1958.tb10362.x","volume":"10","author":"Besley","year":"1958","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.bmc.2016.12.047_b0170","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J Biol Chem"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616312974?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616312974?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:48:06Z","timestamp":1760834886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089616312974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0968089616312974"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2016.12.047","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2016.12.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}