{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:34:06Z","timestamp":1783398846363,"version":"3.54.6"},"reference-count":62,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research, King Saud University","doi-asserted-by":"publisher","award":["RGP-163"],"award-info":[{"award-number":["RGP-163"]}],"id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.bmc.2017.01.032","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T19:40:44Z","timestamp":1485286844000},"page":"1666-1671","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors"],"prefix":"10.1016","volume":"25","author":[{"given":"Alaa A.-M.","family":"Abdel-Aziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel S.","family":"El-Azab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Abu El-Enin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2017.01.032_b0005","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejmech.2014.12.039","volume":"92","author":"Alanazi","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0010","doi-asserted-by":"crossref","first-page":"5185","DOI":"10.1016\/j.bmcl.2014.09.076","volume":"24","author":"Abdel-Aziz","year":"2014","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.01.032_h0015","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bmc.2015.11.034","volume":"24","author":"El-Azab","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_b0015","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1016\/j.bmcl.2013.02.107","volume":"23","author":"Al-Suwaidan","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.01.032_b0020","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.ejmech.2011.02.013","volume":"46","author":"Abdel-Aziz","year":"2011","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_b0025","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1016\/j.ejmech.2011.07.002","volume":"46","author":"Abdel-Aziz","year":"2011","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_b0030","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.ejmech.2006.12.003","volume":"42","author":"Abdel-Aziz","year":"2007","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_b0035","first-page":"573","volume":"4","author":"Liu","year":"2014","journal-title":"Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_b0040","first-page":"337","volume":"17","author":"Scozzafava","year":"2001","journal-title":"Drug Des Discov"},{"key":"10.1016\/j.bmc.2017.01.032_b0045","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.bmc.2014.01.031","volume":"22","author":"Sethi","year":"2014","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_b0050","doi-asserted-by":"crossref","first-page":"5168","DOI":"10.1016\/j.bmc.2013.06.035","volume":"21","author":"Sethi","year":"2013","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_b0055","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.1016\/j.bmc.2013.07.044","volume":"21","author":"Sethi","year":"2013","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0065","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1517\/17460441.2013.795145","volume":"8","author":"De Simone","year":"2013","journal-title":"Expert Opin Drug Discov"},{"key":"10.1016\/j.bmc.2017.01.032_h0070","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1517\/13543776.2013.794788","volume":"23","author":"Masini","year":"2013","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2017.01.032_h0075","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.01.032_h0080","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/17460441.2017.1253677","volume":"12","author":"Supuran","year":"2017","journal-title":"Expert Opin Drug Discov"},{"key":"10.1016\/j.bmc.2017.01.032_h0085","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1042\/BCJ20160115","volume":"473","author":"Supuran","year":"2016","journal-title":"Biochem J"},{"key":"10.1016\/j.bmc.2017.01.032_h0090","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1517\/13543776.2013.782394","volume":"23","author":"Aggarwal","year":"2013","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2017.01.032_h0095","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1517\/13543776.2013.780598","volume":"23","author":"Carta","year":"2013","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2017.01.032_h0100","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2174\/138161208783877956","volume":"14","author":"Thiry","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.bmc.2017.01.032_h0105","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/med.20068","volume":"26","author":"Winum","year":"2006","journal-title":"Med Res Rev"},{"key":"10.1016\/j.bmc.2017.01.032_h0110","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1039\/C6OB00803H","volume":"14","author":"Di Fiore","year":"2016","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0115","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.bmc.2012.06.053","volume":"21","author":"Arechederra","year":"2013","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0120","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1517\/13543776.2013.790957","volume":"23","author":"Scozzafava","year":"2013","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2017.01.032_h0125","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/14756366.2013.761876","volume":"28","author":"Supuran","year":"2013","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0130","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2017.01.032_h0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14756360902784425","volume":"24","author":"Ebbesen","year":"2009","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0140","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2017.01.032_h0145","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1080\/14737175.2016.1193009","volume":"16","author":"Supuran","year":"2016","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.bmc.2017.01.032_h0150","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1016\/j.bmc.2015.02.027","volume":"23","author":"Carta","year":"2015","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0155","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.bmc.2013.02.026","volume":"21","author":"Supuran","year":"2013","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0160","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/14756366.2015.1122001","volume":"31","author":"Supuran","year":"2016","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0165","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2017.01.032_b0090","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah","year":"1971","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0175","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nm1534","volume":"13","author":"Gao","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.bmc.2017.01.032_h0180","doi-asserted-by":"crossref","first-page":"e01597","DOI":"10.1128\/mBio.01597-16","volume":"7","author":"Rose","year":"2016","journal-title":"MBio"},{"key":"10.1016\/j.bmc.2017.01.032_h0185","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1073\/pnas.1001905107","volume":"107","author":"Datta","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2017.01.032_h0190","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1136\/bjophthalmol-2012-303005","volume":"97","author":"Ikeda","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.bmc.2017.01.032_h0195","doi-asserted-by":"crossref","first-page":"5210","DOI":"10.1038\/onc.2012.550","volume":"32","author":"Lock","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.bmc.2017.01.032_h0200","doi-asserted-by":"crossref","first-page":"9101","DOI":"10.1016\/j.bmc.2008.09.028","volume":"16","author":"Bayram","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0205","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.bmcl.2004.12.052","volume":"15","author":"Vullo","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.01.032_b0110","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jinorgbio.2011.11.017","volume":"111","author":"De Simone","year":"2012","journal-title":"J Inorg Biochem"},{"key":"10.1016\/j.bmc.2017.01.032_h0215","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/14756366.2013.879656","volume":"30","author":"Korkmaz","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0220","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3109\/14756366.2014.892936","volume":"30","author":"Akdemir","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0225","doi-asserted-by":"crossref","first-page":"7860","DOI":"10.1021\/jm050483n","volume":"48","author":"Nishimori","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0230","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1021\/jm0108202","volume":"45","author":"Scozzafava","year":"2002","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0235","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3109\/14756366.2014.912215","volume":"30","author":"Sahin","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0240","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3109\/14756366.2014.912216","volume":"30","author":"Bozdag","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0245","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/14756366.2014.917085","volume":"30","author":"De Luca","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0250","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3109\/14756366.2014.918610","volume":"30","author":"Vullo","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0255","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3109\/14756366.2014.931383","volume":"30","author":"Del Prete","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0260","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3109\/14756366.2014.967233","volume":"30","author":"Riafrecha","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0265","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3109\/14756366.2014.928704","volume":"30","author":"G\u00f6\u00e7er","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0270","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3109\/14756366.2014.942659","volume":"30","author":"Ceruso","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0275","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3109\/14756366.2014.944178","volume":"30","author":"Zolfaghari Emameh","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0280","doi-asserted-by":"crossref","first-page":"592","DOI":"10.3109\/14756366.2014.957202","volume":"30","author":"Alafeefy","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0285","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3109\/14756366.2014.956310","volume":"30","author":"Scozzafava","year":"2015","journal-title":"J Enzyme Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0290","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3109\/14756366.2014.963072","volume":"30","author":"Le Darz","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0295","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0223-5234(96)89555-9","volume":"31","author":"Supuran","year":"1996","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0300","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1021\/jm300031j","volume":"55","author":"Carta","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.01.032_h0305","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1016\/j.bmcl.2005.04.055","volume":"15","author":"Puccetti","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.01.032_h0310","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0223-5234(96)85163-4","volume":"31","author":"Supuran","year":"1996","journal-title":"Eur J Med Chem"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616314183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089616314183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:47:48Z","timestamp":1760834868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089616314183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0968089616314183"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2017.01.032","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2017.01.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}