{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:02:01Z","timestamp":1789142521550,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004413","name":"IFS","doi-asserted-by":"publisher","award":["F\/4730-1"],"award-info":[{"award-number":["F\/4730-1"]}],"id":[{"id":"10.13039\/100004413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004413","name":"IFS","doi-asserted-by":"publisher","award":["F\/4730-2F"],"award-info":[{"award-number":["F\/4730-2F"]}],"id":[{"id":"10.13039\/100004413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES\/MES-CUBA","doi-asserted-by":"publisher","award":["169\/12"],"award-info":[{"award-number":["169\/12"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2009\/54598-9"],"award-info":[{"award-number":["2009\/54598-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2011\/14403-4"],"award-info":[{"award-number":["2011\/14403-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2013\/12913-0"],"award-info":[{"award-number":["2013\/12913-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["482400\/2013-7"],"award-info":[{"award-number":["482400\/2013-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.bmc.2017.06.047","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T22:46:45Z","timestamp":1499122005000},"page":"4628-4636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library"],"prefix":"10.1016","volume":"25","author":[{"given":"Jorge","family":"Gonz\u00e1lez-Bacerio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah El Chamy","family":"Maluf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanira","family":"M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isel","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7140-6417","authenticated-orcid":false,"given":"Isabelle","family":"Florent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pollyana M.S.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Budu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana C.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2309-4826","authenticated-orcid":false,"given":"Ernesto","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana K.","family":"Carmona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maday","family":"Alonso del Rivero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos L.","family":"Gazarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2017.06.047_b0005","unstructured":"World Health Organization (WHO). http:\/\/www.who.int\/malaria; 2014 Accessed 15.04.05."},{"key":"10.1016\/j.bmc.2017.06.047_b0010","doi-asserted-by":"crossref","first-page":"35978","DOI":"10.1074\/jbc.M703643200","volume":"282","author":"Dalal","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.06.047_b0015","doi-asserted-by":"crossref","first-page":"E526","DOI":"10.1073\/pnas.1105601108","volume":"108","author":"Harbut","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2017.06.047_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182002001828","volume":"125","author":"Allary","year":"2002","journal-title":"Parasitology"},{"key":"10.1016\/j.bmc.2017.06.047_b0025","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1073\/pnas.0807398106","volume":"106","author":"McGowan","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2017.06.047_b0030","doi-asserted-by":"crossref","first-page":"e31938","DOI":"10.1371\/journal.pone.0031938","volume":"7","author":"Poreba","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2017.06.047_b0035","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pep.2014.08.002","volume":"104","author":"Gonz\u00e1lez-Bacerio","year":"2014","journal-title":"Protein Expr Purif"},{"key":"10.1016\/j.bmc.2017.06.047_b0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/1389200013338748","volume":"2","author":"Scornik","year":"2001","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.bmc.2017.06.047_b0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.7164\/antibiotics.29.97","volume":"29","author":"Umezawa","year":"1976","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.bmc.2017.06.047_b0050","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1021\/jm101227t","volume":"54","author":"Velmourougane","year":"2011","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.06.047_b0055","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1021\/jm061169b","volume":"50","author":"Flipo","year":"2007","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.06.047_b0060","doi-asserted-by":"crossref","first-page":"10909","DOI":"10.1021\/jm301506h","volume":"55","author":"Deprez-Poulain","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.06.047_b0065","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1002\/cmdc.201402140","volume":"9","author":"M\u00e9ndez","year":"2014","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2017.06.047_b0070","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0166-6851(98)00143-1","volume":"97","author":"Florent","year":"1998","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.bmc.2017.06.047_b0075","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1099\/mic.0.26518-0","volume":"149","author":"Chandu","year":"2003","journal-title":"Microbiology"},{"key":"10.1016\/j.bmc.2017.06.047_b0080","first-page":"386","volume":"71","author":"Ugi","year":"1959","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.bmc.2017.06.047_b0085","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/anie.199601731","volume":"35","author":"Demharter","year":"1996","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.bmc.2017.06.047_b0090","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1016\/j.bmc.2006.04.035","volume":"14","author":"Musonda","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.06.047_b0095","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1016\/j.bmcl.2004.05.063","volume":"14","author":"Musonda","year":"2004","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.06.047_b0100","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1016\/S0960-894X(03)00550-X","volume":"13","author":"Flipo","year":"2003","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.06.047_b0105","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1128\/AAC.01327-07","volume":"52","author":"Cunningham","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2017.06.047_b0110","first-page":"798","volume":"25","author":"Scornik","year":"1997","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.bmc.2017.06.047_b0115","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/ijc.1492","volume":"94","author":"Sekine","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.bmc.2017.06.047_b0120","doi-asserted-by":"crossref","first-page":"27255","DOI":"10.1074\/jbc.M111.225318","volume":"286","author":"Ragheb","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.06.047_b0125","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1074\/jbc.M609251200","volume":"282","author":"Stack","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.06.047_b0130","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1182\/blood-2005-11-026963","volume":"109","author":"Martin","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bmc.2017.06.047_b0135","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0166-6851(01)00327-9","volume":"117","author":"Gavigan","year":"2001","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.bmc.2017.06.047_b0140","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s004360050447","volume":"84","author":"Nankya-Kitaka","year":"1998","journal-title":"Parasitol Res"},{"key":"10.1016\/j.bmc.2017.06.047_b0145","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1550-7408.1994.tb01483.x","volume":"41","author":"Curley","year":"1994","journal-title":"J Eukaryot Microbiol"},{"key":"10.1016\/j.bmc.2017.06.047_b0150","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1074\/jbc.M508955200","volume":"281","author":"Gardiner","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.06.047_b0155","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1073\/pnas.0911813107","volume":"107","author":"McGowan","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2017.06.047_b0160","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tibs.2009.08.004","volume":"35","author":"Skinner-Adams","year":"2010","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.bmc.2017.06.047_b0165","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1128\/AAC.06245-11","volume":"56","author":"Skinner-Adams","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2017.06.047_b0170","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature01097","volume":"419","author":"Gardner","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2017.06.047_b0175","doi-asserted-by":"crossref","first-page":"17966","DOI":"10.1073\/pnas.1210123109","volume":"109","author":"Chen","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2017.06.047_b0180","doi-asserted-by":"crossref","first-page":"e0115859","DOI":"10.1371\/journal.pone.0115859","volume":"10","author":"Paiardini","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2017.06.047_b0185","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.ijpara.2010.10.009","volume":"41","author":"Nogueira da Cruz","year":"2011","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.bmc.2017.06.047_b0190","doi-asserted-by":"crossref","first-page":"33213","DOI":"10.1074\/jbc.274.47.33213","volume":"274","author":"Saliba","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.06.047_b0195","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.bmc.2017.06.047_b0200","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","volume":"65","author":"Lambros","year":"1979","journal-title":"J Parasitol"},{"key":"10.1016\/j.bmc.2017.06.047_b0205","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1128\/AAC.16.6.710","volume":"16","author":"Desjardins","year":"1979","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2017.06.047_b0210","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617307290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617307290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:49:37Z","timestamp":1760834977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089617307290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":42,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0968089617307290"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2017.06.047","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2017.06.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}