{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:03:40Z","timestamp":1777640620773,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["14-50-00069"],"award-info":[{"award-number":["14-50-00069"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.bmc.2017.06.054","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T15:15:30Z","timestamp":1499786130000},"page":"4560-4565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads"],"prefix":"10.1016","volume":"25","author":[{"given":"Marta","family":"Ferraroni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Lucarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Masini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Korsakov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Scozzafava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Krasavin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2017.06.054_b0005","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2017.06.054_b0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1136\/bjo.2005.081224","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.bmc.2017.06.054_b0015","doi-asserted-by":"crossref","unstructured":"Mincione F, Menabuoni L, Supuran CT. In: Supuran CT, Scozzafava A, Conway J. (Eds.), Carbonic Anhydrase \u2013 Its Inhibitors and Activators, CRC Press, Boca Raton (FL), 2004, pp. 243\u2013254.","DOI":"10.1201\/9780203475300.ch8"},{"key":"10.1016\/j.bmc.2017.06.054_b0020","series-title":"Drug Design of Zinc-Enzyme Inhibitors Functional, Structural, and Disease Applications","first-page":"139","author":"Mincione","year":"2009"},{"key":"10.1016\/j.bmc.2017.06.054_b0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1517\/13543776.2012.649006","volume":"22","author":"Carta","year":"2012","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2017.06.054_b0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0002-9394(14)78354-0","volume":"32","author":"Friedenwald","year":"1949","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.bmc.2017.06.054_b0035","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/archopht.1953.00920030409001","volume":"50","author":"Kinsey","year":"1953","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.bmc.2017.06.054_b0040","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0002-9394(14)78372-2","volume":"32","author":"Kinsey","year":"1949","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.bmc.2017.06.054_b0045","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1748-1716.1951.tb00833.x","volume":"24","author":"Wistrand","year":"1951","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.bmc.2017.06.054_b0050","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0002-9394(55)90022-2","volume":"39","author":"Becker","year":"1955","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.bmc.2017.06.054_b0055","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1001\/archopht.1959.04220010082009","volume":"62","author":"Kinsey","year":"1959","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.bmc.2017.06.054_b0060","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1517\/13543776.10.5.575","volume":"10","author":"Supuran","year":"2000","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2017.06.054_b0065","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2017.06.054_b0070","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.06.054_b0075","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.2174\/138161210793429797","volume":"16","author":"Supuran","year":"2010","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.bmc.2017.06.054_h0080","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/med.10025","volume":"23","author":"Supuran","year":"2003","journal-title":"Med Res Rev"},{"key":"10.1016\/j.bmc.2017.06.054_h0085","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1021\/jm9900523","volume":"42","author":"Scozzafava","year":"1999","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.06.054_h0090","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1021\/jm9901879","volume":"42","author":"Scozzafava","year":"1999","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.06.054_h0095","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/physrev.1967.47.4.595","volume":"47","author":"Maren","year":"1967","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bmc.2017.06.054_h0100","series-title":"Carbonic anhydrase \u2013 Its Inhibitors and Activators","first-page":"67","article-title":"Casini A","author":"Supuran","year":"2004"},{"key":"10.1016\/j.bmc.2017.06.054_h0105","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1021\/jm000296j","volume":"43","author":"Scozzafava","year":"2000","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.06.054_b0090","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1021\/jm0108202","volume":"45","author":"Scozzafava","year":"2002","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.06.054_b0095","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2017.06.054_b0100","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","volume":"27","author":"Supuran","year":"2012","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2017.06.054_b0105","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1517\/17425255.2016.1154534","volume":"12","author":"Supuran","year":"2016","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.bmc.2017.06.054_b0110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/17460441.2017.1253677","volume":"12","author":"Supuran","year":"2017","journal-title":"Expert Opin Drug Discov"},{"key":"10.1016\/j.bmc.2017.06.054_b0115","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ejmech.2015.06.022","volume":"101","author":"Krasavin","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2017.06.054_b0120","first-page":"41","volume":"Vol. 245","author":"Leslie","year":"2007"},{"key":"10.1016\/j.bmc.2017.06.054_b0125","first-page":"240","volume":"D53","author":"Murshudov","year":"1997","journal-title":"Acta Cryst"},{"key":"10.1016\/j.bmc.2017.06.054_b0130","first-page":"486","volume":"D66","author":"Emsley","year":"2010","journal-title":"Acta Cryst"},{"key":"10.1016\/j.bmc.2017.06.054_b0135","unstructured":"Lamzin VS, Perrakis A, Wilson KS. In: Rossmann MG, Arnold E. (eds.), Int. Tables for Crystallography. Vol. F: Crystallography of biological macromolecules, Kluwer Academic Publishers, Dordrecht: The Netherlands 2001, pp. 720\u2013722."},{"key":"10.1016\/j.bmc.2017.06.054_b0140","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/prot.10286","volume":"50","author":"Lovell","year":"2003","journal-title":"C Proteins: Struct Funct Genet"},{"key":"10.1016\/j.bmc.2017.06.054_b0145","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"Pettersen","year":"2004","journal-title":"J Comput Chem"},{"key":"10.1016\/j.bmc.2017.06.054_h0170","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/jop.2009.0120","volume":"26","author":"Borghi","year":"2010","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1016\/j.bmc.2017.06.054_h0175","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3109\/14756366.2011.597749","volume":"27","author":"Fabrizi","year":"2012","journal-title":"J Enzyme Inhib Med Chem"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617314001?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617314001?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:51:00Z","timestamp":1760835060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089617314001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":35,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0968089617314001"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2017.06.054","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2017.06.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}