{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:32:41Z","timestamp":1769747561791,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2015M1A5A1037230"],"award-info":[{"award-number":["NRF-2015M1A5A1037230"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009695","name":"Catholic Kwandong University","doi-asserted-by":"crossref","award":["CKURF-20140696000"],"award-info":[{"award-number":["CKURF-20140696000"]}],"id":[{"id":"10.13039\/501100009695","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.bmc.2017.07.002","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T13:47:52Z","timestamp":1499348872000},"page":"4649-4655","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["A novel antihypertension agent, sargachromenol D from marine brown algae, Sargassum siliquastrum, exerts dual action as an L-type Ca2+ channel blocker and endothelin A\/B2 receptor antagonist"],"prefix":"10.1016","volume":"25","author":[{"given":"Byong-Gon","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woon-Seob","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangtae","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gab-Man","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Ik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seokjoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2017.07.002_b0005","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/embor.2009.12","volume":"10","author":"Ji","year":"2009","journal-title":"EMBO Rep"},{"key":"10.1016\/j.bmc.2017.07.002_b0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4236\/pp.2013.43A003","volume":"4","author":"Lahlou","year":"2013","journal-title":"Pharmacol Pharm"},{"key":"10.1016\/j.bmc.2017.07.002_b0015","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3390\/metabo2020303","volume":"2","author":"Dias","year":"2012","journal-title":"Metabolites"},{"key":"10.1016\/j.bmc.2017.07.002_b0020","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1021\/jm0704090","volume":"51","author":"Newman","year":"2008","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.07.002_b0025","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1021\/ci700286x","volume":"48","author":"Ertl","year":"2008","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2017.07.002_b0030","first-page":"105","volume":"5","author":"Nilakantan","year":"2002","journal-title":"Comb Chem High Throughput Screen"},{"key":"10.1016\/j.bmc.2017.07.002_b0035","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/(SICI)1521-3773(19990301)38:5<643::AID-ANIE643>3.0.CO;2-G","volume":"38","author":"Henkel","year":"1999","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2017.07.002_b0040","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S1359-6446(03)02713-2","volume":"8","author":"Haefner","year":"2003","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bmc.2017.07.002_b0045","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/00005344-199710000-00015","volume":"30","author":"Komuro","year":"1997","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.bmc.2017.07.002_b0050","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1016\/j.bmcl.2008.03.034","volume":"18","author":"Park","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.07.002_b0055","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1016\/j.bmcl.2008.10.103","volume":"18","author":"Park","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.07.002_b0060","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1016\/j.bmcl.2010.05.044","volume":"20","author":"Oh","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.07.002_b0065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.vph.2013.02.001","volume":"58","author":"Shin","year":"2013","journal-title":"Vasc Pharmacol"},{"key":"10.1016\/j.bmc.2017.07.002_b0070","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1291\/hypres.28.331","volume":"28","author":"Ogihara","year":"2005","journal-title":"Hypertens Res"},{"key":"10.1016\/j.bmc.2017.07.002_b0075","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1161\/01.HYP.30.2.278","volume":"30","author":"K-Laflamme","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.bmc.2017.07.002_b0080","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2174\/1874467211104030176","volume":"4","author":"Khalil","year":"2011","journal-title":"Curr Mol Pharmacol"},{"key":"10.1016\/j.bmc.2017.07.002_b0085","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s12272-009-1801-1","volume":"32","author":"Napoli","year":"2009","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.bmc.2017.07.002_b0090","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1006\/jmcc.1998.0839","volume":"31","author":"Fleming","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.bmc.2017.07.002_b0095","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1113\/expphysiol.2007.038588","volume":"93","author":"Mitchell","year":"2008","journal-title":"Exp Physiol"},{"key":"10.1016\/j.bmc.2017.07.002_b0100","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1161\/01.ATV.0000217611.81085.c5","volume":"26","author":"Feletou","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.bmc.2017.07.002_b0105","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/332411a0","volume":"332","author":"Yanagisawa","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2017.07.002_b0110","doi-asserted-by":"crossref","first-page":"381","DOI":"10.33549\/physiolres.932189","volume":"60","author":"Pint\u00e9rov\u00e1","year":"2011","journal-title":"Physiol Res"},{"key":"10.1016\/j.bmc.2017.07.002_b0115","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.vph.2005.10.005","volume":"44","author":"Sonkusare","year":"2006","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.bmc.2017.07.002_b0120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1520-037X.2006.4473.x","volume":"9","author":"Vogel","year":"2006","journal-title":"Prev Cardiol"},{"key":"10.1016\/j.bmc.2017.07.002_b0125","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/01.HYP.33.2.759","volume":"33","author":"Matsumura","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.bmc.2017.07.002_b0130","doi-asserted-by":"crossref","first-page":"8226","DOI":"10.1128\/MCB.23.22.8226-8232.2003","volume":"23","author":"Kedzierski","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.bmc.2017.07.002_b0135","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00019501-200311000-00002","volume":"14","author":"Barton","year":"2003","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.bmc.2017.07.002_b0140","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/348730a0","volume":"348","author":"Arai","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2017.07.002_b0145","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/348732a0","volume":"348","author":"Sakurai","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2017.07.002_b0150","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1161\/01.CIR.102.19.2434","volume":"102","author":"Luscher","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.bmc.2017.07.002_b0155","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1152\/ajpcell.1992.262.4.C854","volume":"262","author":"Marsden","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.bmc.2017.07.002_b0160","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1006\/bbrc.1998.8543","volume":"245","author":"Hu","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmc.2017.07.002_b0165","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.1073\/pnas.90.13.5999","volume":"90","author":"Malek","year":"1993","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bmc.2017.07.002_b0170","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.lfs.2012.03.029","volume":"92","author":"Pernow","year":"2012","journal-title":"Life Sci"},{"key":"10.1016\/j.bmc.2017.07.002_b0175","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2362.2009.02120.x","volume":"39","author":"Davie","year":"2009","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.bmc.2017.07.002_b0180","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/01.HYP.25.6.1135","volume":"25","author":"Schiffrin","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.bmc.2017.07.002_b0185","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1161\/01.CIR.100.8.820","volume":"100","author":"Cardillo","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.bmc.2017.07.002_b0190","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0008-6363(02)00593-X","volume":"56","author":"Eringa","year":"2002","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.bmc.2017.07.002_b0195","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1097\/00004872-199816121-00007","volume":"16","author":"Schiffrin","year":"1998","journal-title":"J Hypertens"},{"key":"10.1016\/j.bmc.2017.07.002_b0205","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1246\/cl.1979.1181","author":"Kusumi","year":"1979","journal-title":"Chem Lett"},{"key":"10.1016\/j.bmc.2017.07.002_b0210","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1021\/np058003i","volume":"68","author":"Jang","year":"2005","journal-title":"J Nat Prod"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617305461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617305461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:49:46Z","timestamp":1760834986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089617305461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":41,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0968089617305461"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2017.07.002","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel antihypertension agent, sargachromenol D from marine brown algae, Sargassum siliquastrum, exerts dual action as an L-type Ca2+ channel blocker and endothelin A\/B2 receptor antagonist","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2017.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}