{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:30:00Z","timestamp":1787319000312,"version":"build-2736575974"},"reference-count":65,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.bmc.2017.07.039","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T04:46:20Z","timestamp":1500612380000},"page":"4894-4903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Fluoro and pentafluorothio analogs of the antitumoral curcuminoid EF24 with superior antiangiogenic and vascular-disruptive effects"],"prefix":"10.1016","volume":"25","author":[{"given":"Florian","family":"Schmitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"Begemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ion","family":"Andronache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Biersack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Schobert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2017.07.039_b0005","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1158\/1940-6207.CAPR-10-0098","volume":"4","author":"Carroll","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.bmc.2017.07.039_b0010","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1158\/1078-0432.CCR-04-0744","volume":"10","author":"Sharma","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.bmc.2017.07.039_b0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2407-9-99","volume":"9","author":"Cen","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bmc.2017.07.039_b0020","first-page":"4491","volume":"14","author":"Dhillon","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmc.2017.07.039_b0025","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1182\/blood-2002-05-1320","volume":"101","author":"Bharti","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bmc.2017.07.039_b0030","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/carcin\/bgg082","volume":"24","author":"Woo","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bmc.2017.07.039_b0035","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1038\/sj.onc.1202980","volume":"18","author":"Plummer","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.bmc.2017.07.039_b0040","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1016\/j.bmc.2004.05.006","volume":"12","author":"Adams","year":"2004","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.07.039_b0045","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2006-957450","volume":"64","author":"Shoba","year":"1998","journal-title":"Planta Med"},{"key":"10.1016\/j.bmc.2017.07.039_b0050","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/carcin\/19.6.1039","volume":"19","author":"Singletary","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bmc.2017.07.039_b0055","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00001813-200503000-00005","volume":"16","author":"Adams","year":"2005","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.bmc.2017.07.039_b0060","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejmech.2013.10.073","volume":"71","author":"Leow","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2017.07.039_b0065","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bmcl.2012.11.004","volume":"23","author":"Manohar","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.07.039_b0070","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1021\/jm4002692","volume":"56","author":"Brown","year":"2013","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.07.039_b0075","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1039\/c2ib20045g","volume":"4","author":"Yamaguchi","year":"2012","journal-title":"Integr Biol"},{"key":"10.1016\/j.bmc.2017.07.039_b0080","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.bmcl.2012.12.016","volume":"23","author":"Helal","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.07.039_b0085","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1039\/C3MD00399J","volume":"5","author":"Thakur","year":"2014","journal-title":"MedChemComm."},{"key":"10.1016\/j.bmc.2017.07.039_b0090","doi-asserted-by":"crossref","first-page":"28609","DOI":"10.1074\/jbc.M703796200","volume":"282","author":"Selvendiran","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.07.039_b0095","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.4161\/cc.6410","volume":"7","author":"Thomas","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bmc.2017.07.039_b0100","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1158\/0008-5472.CAN-07-6011","volume":"68","author":"Subramaniam","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmc.2017.07.039_b0105","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molstruc.2009.07.016","volume":"936","author":"Lagisetty","year":"2009","journal-title":"J Mol Struct"},{"key":"10.1016\/j.bmc.2017.07.039_b0110","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1158\/1535-7163.MCT-06-0174","volume":"5","author":"Ohori","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.bmc.2017.07.039_b0115","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1124\/mol.108.046201","volume":"74","author":"Kasinski","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bmc.2017.07.039_b0120","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1021\/jm200353f","volume":"54","author":"K\u00e1lai","year":"2011","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.07.039_b0125","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00280-016-3172-x","volume":"78","author":"He","year":"2016","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.bmc.2017.07.039_b0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jfluchem.2012.06.030","volume":"143","author":"Altomonte","year":"2012","journal-title":"J Fluor Chem."},{"key":"10.1016\/j.bmc.2017.07.039_b0135","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1016\/j.bmc.2013.03.057","volume":"21","author":"Wu","year":"2013","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.07.039_b0140","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.canlet.2005.05.045","volume":"237","author":"Visanji","year":"2006","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bmc.2017.07.039_b0145","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1126\/science.274.5288.784","volume":"274","author":"Wang","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bmc.2017.07.039_b0150","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0006-2952(02)01154-1","volume":"64","author":"Alok","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bmc.2017.07.039_b0155","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ni.2060","volume":"12","author":"Ben-Neriah","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.bmc.2017.07.039_b0160","doi-asserted-by":"crossref","first-page":"a000034","DOI":"10.1101\/cshperspect.a000034","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.bmc.2017.07.039_b0165","doi-asserted-by":"crossref","first-page":"e18713","DOI":"10.1371\/journal.pone.0018713","volume":"6","author":"King","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2017.07.039_b0170","doi-asserted-by":"crossref","first-page":"6938","DOI":"10.1038\/sj.onc.1203221","volume":"18","author":"Rayet","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.bmc.2017.07.039_b0175","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/nri887","volume":"2","author":"Richmond","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bmc.2017.07.039_b0180","doi-asserted-by":"crossref","first-page":"7597","DOI":"10.1038\/sj.onc.1204997","volume":"20","author":"Mukhopadhyay","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.bmc.2017.07.039_b0185","doi-asserted-by":"crossref","first-page":"24995","DOI":"10.1074\/jbc.270.42.24995","volume":"270","author":"Singh","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.07.039_b0190","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/sj.bjc.6605530","volume":"102","author":"Wu","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.bmc.2017.07.039_b0195","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1038\/sj.onc.1210546","volume":"26","author":"Julien","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.bmc.2017.07.039_b0200","first-page":"9270","volume":"9","author":"Zhang","year":"2016","journal-title":"Clin Exp Med."},{"key":"10.1016\/j.bmc.2017.07.039_b0205","doi-asserted-by":"crossref","first-page":"e93208","DOI":"10.1371\/journal.pone.0093208","volume":"9","author":"Kumar","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2017.07.039_b0210","doi-asserted-by":"crossref","first-page":"32167","DOI":"10.1038\/srep32167","volume":"6","author":"Yin","year":"2016","journal-title":"Sci Rep."},{"key":"10.1016\/j.bmc.2017.07.039_b0215","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S0006-291X(02)02306-9","volume":"297","author":"Gururaj","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmc.2017.07.039_b0220","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1177\/1933719110374239","volume":"17","author":"Xin","year":"2010","journal-title":"Reprod Sci"},{"key":"10.1016\/j.bmc.2017.07.039_b0225","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1158\/1535-7163.MCT-11-0399","volume":"10","author":"Subramaniam","year":"2011","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.bmc.2017.07.039_b0230","doi-asserted-by":"crossref","first-page":"e1600302","DOI":"10.1002\/cbdv.201600302","volume":"14","author":"Draut","year":"2017","journal-title":"Chem Biodivers"},{"key":"10.1016\/j.bmc.2017.07.039_b0235","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1006\/dbio.2002.0711","volume":"248","author":"Lawson","year":"2002","journal-title":"Dev Biol."},{"key":"10.1016\/j.bmc.2017.07.039_b0240","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1038\/nprot.2007.412","volume":"2","author":"Nicoli","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.bmc.2017.07.039_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cmdc.201400049","volume":"9","author":"Muenzner","year":"2014","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2017.07.039_b0250","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1006\/mvre.1996.0002","volume":"51","author":"Kirchner","year":"1996","journal-title":"Microvasc Res"},{"key":"10.1016\/j.bmc.2017.07.039_b0255","doi-asserted-by":"crossref","first-page":"R69","DOI":"10.1186\/bcr1626","volume":"8","author":"Basu","year":"2006","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.bmc.2017.07.039_b0260","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/sj.onc.1210691","volume":"27","author":"Scavelli","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.bmc.2017.07.039_b0265","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/brain\/awq044","volume":"133","author":"El Hallani","year":"2010","journal-title":"Brain."},{"key":"10.1016\/j.bmc.2017.07.039_b0270","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrc1092","volume":"3","author":"Hendrix","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bmc.2017.07.039_b0275","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.2353\/ajpath.2006.060223","volume":"169","author":"Folberg","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.bmc.2017.07.039_b0280","first-page":"278","volume":"5","author":"Hu","year":"2015","journal-title":"Am J Cancer Res."},{"key":"10.1016\/j.bmc.2017.07.039_b0285","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4161\/cbt.11.2.13842","volume":"11","author":"Chen","year":"2011","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.bmc.2017.07.039_b0290","first-page":"1857","volume":"34","author":"Chiablaem","year":"2014","journal-title":"Anticancer Res"},{"key":"10.1016\/j.bmc.2017.07.039_b0295","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/35000034","volume":"2","author":"Batlle","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.bmc.2017.07.039_b0300","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/35000025","volume":"2","author":"Cano","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.bmc.2017.07.039_b0305","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10911-010-9179-8","volume":"15","author":"De Herreros","year":"2010","journal-title":"J Mammary Gland Biol."},{"key":"10.1016\/j.bmc.2017.07.039_b0310","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1158\/1535-7163.MCT-09-1207","volume":"9","author":"Selvendiran","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.bmc.2017.07.039_b0315","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1002\/cncr.10812","volume":"95","author":"Hidaka","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.bmc.2017.07.039_b0320","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/sj.bjc.6605725","volume":"103","author":"Nitzsche","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.bmc.2017.07.039_b0325","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.stem.2007.11.002","volume":"2","author":"White","year":"2008","journal-title":"Cell Stem Cell"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617306156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617306156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:50:34Z","timestamp":1760835034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089617306156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":65,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0968089617306156"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2017.07.039","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluoro and pentafluorothio analogs of the antitumoral curcuminoid EF24 with superior antiangiogenic and vascular-disruptive effects","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2017.07.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}