{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:19:17Z","timestamp":1787789957723,"version":"build-2784847793"},"reference-count":45,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T00:00:00Z","timestamp":1555459200000},"content-version":"am","delay-in-days":381,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society Translational Research","doi-asserted-by":"publisher","award":["LLS-6116-14"],"award-info":[{"award-number":["LLS-6116-14"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. National Institute of Health","doi-asserted-by":"publisher","award":["GM098628"],"award-info":[{"award-number":["GM098628"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["CA180615"],"award-info":[{"award-number":["CA180615"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"U.S. National Science Foundation","doi-asserted-by":"publisher","award":["CHE-0946653"],"award-info":[{"award-number":["CHE-0946653"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.bmc.2017.08.009","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T11:46:54Z","timestamp":1502192814000},"page":"1365-1373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis"],"prefix":"10.1016","volume":"26","author":[{"given":"Hanan","family":"Alwaseem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Frisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4636-9578","authenticated-orcid":false,"given":"Rudi","family":"Fasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2017.08.009_b0005","series-title":"Terpenes: Flavors, Fragrances, Pharmaca","author":"Breitmaier","year":"2006"},{"key":"10.1016\/j.bmc.2017.08.009_b0010","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.drudis.2010.06.002","volume":"15","author":"Ghantous","year":"2010","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bmc.2017.08.009_b0015","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.drudis.2013.05.005","volume":"18","author":"Ghantous","year":"2013","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bmc.2017.08.009_b0020","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1182\/blood-2004-10-4135","volume":"105","author":"Guzman","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bmc.2017.08.009_b0025","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1517\/14712598.5.9.1147","volume":"5","author":"Guzman","year":"2005","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.bmc.2017.08.009_b0030","doi-asserted-by":"crossref","first-page":"e0116202","DOI":"10.1371\/journal.pone.0116202","volume":"10","author":"An","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bmc.2017.08.009_b0035","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/j.bmcl.2015.04.058","volume":"25","author":"Hexum","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.08.009_b0040","doi-asserted-by":"crossref","first-page":"8896","DOI":"10.1021\/acs.jmedchem.5b01187","volume":"58","author":"Janganati","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0045","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1016\/j.bmc.2015.05.037","volume":"23","author":"Kempema","year":"2015","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0050","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.bmc.2010.12.045","volume":"19","author":"Nasim","year":"2011","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0055","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1016\/j.bmcl.2006.05.083","volume":"16","author":"Srivastava","year":"2006","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.08.009_b0060","doi-asserted-by":"crossref","first-page":"8757","DOI":"10.1021\/jm301064b","volume":"55","author":"Zhang","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0065","doi-asserted-by":"crossref","first-page":"39713","DOI":"10.1074\/jbc.M101985200","volume":"276","author":"Garcia-Pineres","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0070","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1074\/jbc.273.3.1288","volume":"273","author":"Hehner","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0075","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1158\/1535-7163.MCT-08-0661","volume":"8","author":"Gopal","year":"2009","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.bmc.2017.08.009_b0080","doi-asserted-by":"crossref","first-page":"33542","DOI":"10.1074\/jbc.M113.511170","volume":"288","author":"Pei","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/15680096113136660108","volume":"14","author":"Jung","year":"2014","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.bmc.2017.08.009_b0090","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.canlet.2004.03.033","volume":"211","author":"Zhang","year":"2004","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bmc.2017.08.009_b0095","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1124\/jpet.108.147934","volume":"329","author":"Liu","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.bmc.2017.08.009_b0100","doi-asserted-by":"crossref","first-page":"e1608","DOI":"10.1038\/cddis.2014.569","volume":"6","author":"Nakshatri","year":"2015","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.bmc.2017.08.009_b0105","first-page":"74a","volume":"108","author":"Guzman","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bmc.2017.08.009_b0110","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1021\/jo901533e","volume":"74","author":"Han","year":"2009","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0115","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1016\/j.bmcl.2008.06.050","volume":"18","author":"Nasim","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.08.009_b0120","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1016\/j.bmcl.2009.05.092","volume":"19","author":"Neelakantan","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2017.08.009_b0125","doi-asserted-by":"crossref","first-page":"7934","DOI":"10.1021\/jm201114t","volume":"54","author":"Woods","year":"2011","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0130","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1021\/cb400626w","volume":"9","author":"Kolev","year":"2014","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.bmc.2017.08.009_b0135","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1016\/j.bmc.2016.06.028","volume":"24","author":"Tyagi","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0140","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1021\/jm501371s","volume":"58","author":"Ghosh","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0145","doi-asserted-by":"crossref","first-page":"551","DOI":"10.3109\/03602531003745960","volume":"42","author":"Vacondio","year":"2010","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.bmc.2017.08.009_b0150","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ctrv.2016.08.001","volume":"50","author":"Lam","year":"2016","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.bmc.2017.08.009_b0155","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1021\/jm800038g","volume":"51","author":"Brickner","year":"2008","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0160","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/hiv.12211","volume":"16","author":"Ruane","year":"2015","journal-title":"HIV Med"},{"key":"10.1016\/j.bmc.2017.08.009_b0165","doi-asserted-by":"crossref","first-page":"e1095","DOI":"10.1542\/peds.2013-4221","volume":"134","author":"Sangal","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.bmc.2017.08.009_b0170","doi-asserted-by":"crossref","first-page":"6683","DOI":"10.1016\/S0021-9258(18)48296-8","volume":"262","author":"Narhi","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0175","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1128\/AEM.71.10.5728-5734.2005","volume":"71","author":"Johannes","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.bmc.2017.08.009_b0180","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/bit.21546","volume":"99","author":"McLachlan","year":"2008","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.bmc.2017.08.009_b0185","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1073\/pnas.1015253108","volume":"108","author":"Cui","year":"2011","journal-title":"PNAS"},{"key":"10.1016\/j.bmc.2017.08.009_b0190","doi-asserted-by":"crossref","first-page":"22434","DOI":"10.1039\/c4ra02316a","volume":"4","author":"Labafzadeh","year":"2014","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmc.2017.08.009_b0195","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1158\/1535-7163.MCT-05-0030","volume":"4","author":"Sweeney","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.bmc.2017.08.009_b0200","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10549-007-9798-y","volume":"111","author":"Zhou","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.bmc.2017.08.009_b0205","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/pros.20931","volume":"69","author":"Kawasaki","year":"2009","journal-title":"Prostate"},{"key":"10.1016\/j.bmc.2017.08.009_b0210","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1158\/1535-7163.MCT-04-0215","volume":"4","author":"Yip-Schneider","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.bmc.2017.08.009_b0215","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ejmech.2013.08.053","volume":"69","author":"Kumar","year":"2013","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2017.08.009_b0220","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0975-7406.171694","volume":"8","author":"Naim","year":"2016","journal-title":"Pharm Bioall Sci"},{"key":"10.1016\/j.bmc.2017.08.009_b0225","doi-asserted-by":"crossref","first-page":"25280","DOI":"10.1074\/jbc.A116.750653","volume":"291","author":"Pei","year":"2016","journal-title":"J Biol Chem"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617309094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617309094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:53:47Z","timestamp":1760835227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089617309094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0968089617309094"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2017.08.009","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2017.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}